Search Results - "Weimer, L K"

Histamine-stimulated cytokine secretion from human conjunctival epithelial cells: inhibition by the histamine H1 antagonist emedastine by Weimer, L K, Gamache, D A, Yanni, J M

“…The present studies demonstrate that histamine induces the secretion of IL-6, IL-8 and GM-CSF from human conjunctival epithelial cells in a dose- and…”
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The in vitro and in vivo ocular pharmacology of olopatadine (AL-4943A), an effective anti-allergic/antihistaminic agent by Yanni, J M, Stephens, D J, Miller, S T, Weimer, L K, Graff, G, Parnell, D, Lang, L S, Spellman, J M, Brady, M T, Gamache, D A

“…Olopatadine (AL-4943A; KW-4679) [(z)-11-[3-(dimethylamino)propylidene]-6, 11-dihydrodibenz[b,e]oxepine-2 acetic acid hydrochloride] is an anti-allergic agent…”
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Effect of lodoxamide on in vitro and in vivo conjunctival immediate hypersensitivity responses in rats by Yanni, J M, Weimer, L K, Glaser, R L, Lang, L S, Robertson, S M, Spellman, J M

“…The antiallergic compound, lodoxamide, was evaluated for its abilities to attenuate a local allergic reaction in rat conjunctiva in vivo and to inhibit rat…”
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Inhibition of histamine-induced human conjunctival epithelial cell responses by ocular allergy drugs by Yanni, J M, Weimer, L K, Sharif, N A, Xu, S X, Gamache, D A, Spellman, J M

“…To evaluate the effects of topical ocular drugs with histamine H1-antagonist activity on histamine-stimulated phosphatidylinositol turnover and interleukin…”
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A Current Appreciation of Sites for Pharmacological Intervention in Allergic Conjunctivitis: Effects of New Topical Ocular Drugs by Yanni, J. M., Sharif, N. A., Gamache, D. A., Miller, S. T., Weimer, L. K., Spellman, J. M.

“…Two important realizations about pathophysiological mechanisms involved in allergic conjunctivitis have led to novel drug discovery efforts and new topical…”
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Secretion of proinflammatory cytokines by human conjunctival epithelial cells by Gamache, Daniel A., Dimitrijevich, S. Dan, Weimer, Lori K., Lang, Laura S., Spellman, Joan M., Graff, Gustav, Yanni, John M.

“…The production of cytokines by human conjunctival epithelial cells following stimulation was investigated. Primary cultures of human conjunctival epithelial…”
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Characterization of the in vitro anti-inflammatory activity of AL-5898 and related benzopyranyl esters and amides by David, Karen C, Brady, Milton T, Weimer, Lori K, Hellberg, Mark R, Nixon, Jon C, Graff, Gustav

“…Selected ester- (AL-5898 and AL-8417) and amide-linked benzopyran analogues (AL-7538 and AL-12615) were evaluated in vitro for their ability to inhibit key…”
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Corneal protection by the ocular mucin secretagogue 15(S)-HETE in a rabbit model of desiccation-induced corneal defect by Gamache, Daniel A, Wei, Zhong-You, Weimer, Lori K, Miller, Steven T, Spellman, Joan M, Yanni, John M

“…The mucin secretagogue 15(S)-HETE was found to stimulate glycoprotein secretion in human ocular tissue at submicromolar concentrations in the present studies…”
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Preservation of corneal integrity by the mucin secretagogue 15(S)-HETE in a rabbit model of desiccation-induced dry eye by Gamache, Daniel A, Wei, Zhong-you, Weimer, Lori K, Spellman, Joan M, Yanni, John M

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