Search Results - "Weilandt, Daniel R"
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Slow TCA flux and ATP production in primary solid tumours but not metastases
Published in Nature (London) (09-02-2023)“…Tissues derive ATP from two pathways—glycolysis and the tricarboxylic acid (TCA) cycle coupled to the electron transport chain. Most energy in mammals is…”
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Optimal enzyme utilization suggests that concentrations and thermodynamics determine binding mechanisms and enzyme saturations
Published in Nature communications (05-05-2023)“…Deciphering the metabolic functions of organisms requires understanding the dynamic responses of living cells upon genetic and environmental perturbations,…”
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Single-molecule kinetic analysis of HP1-chromatin binding reveals a dynamic network of histone modification and DNA interactions
Published in Nucleic acids research (13-10-2017)“…Chromatin recruitment of effector proteins involved in gene regulation depends on multivalent interaction with histone post-translational modifications (PTMs)…”
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Particle-Based Simulation Reveals Macromolecular Crowding Effects on the Michaelis-Menten Mechanism
Published in Biophysical journal (23-07-2019)“…Many computational models for analyzing and predicting cell physiology rely on in vitro data collected in dilute and controlled buffer solutions. However, this…”
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Symbolic kinetic models in python (SKiMpy): intuitive modeling of large-scale biological kinetic models
Published in Bioinformatics (Oxford, England) (01-01-2023)“…Abstract Motivation Large-scale kinetic models are an invaluable tool to understand the dynamic and adaptive responses of biological systems. The development…”
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