Search Results - "Weikel, Karen A"

Resveratrol prevents oxidative stress-induced senescence and proliferative dysfunction by activating the AMPK-FOXO3 cascade in cultured primary human keratinocytes by Ido, Yasuo, Duranton, Albert, Lan, Fan, Weikel, Karen A, Breton, Lionel, Ruderman, Neil B

“…The aging process is perceived as resulting from a combination of intrinsic factors such as changes in intracellular signaling and extrinsic factors, most…”
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Resveratrol-Induced AMP-Activated Protein Kinase Activation Is Cell-Type Dependent: Lessons from Basic Research for Clinical Application by Lan, Fan, Weikel, Karen A, Cacicedo, Jose M, Ido, Yasuo

“…Despite the promising effects of resveratrol, its efficacy in the clinic remains controversial. We were the first group to report that the SIRT1 activator…”
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Nutritional modulation of age-related macular degeneration by Weikel, Karen A., Chiu, Chung–Jung, Taylor, Allen

“…Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly worldwide. It affects 30–50 million individuals and clinical hallmarks…”
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Glucose and palmitate uncouple AMPK from autophagy in human aortic endothelial cells by Weikel, Karen A, Cacicedo, José M, Ruderman, Neil B, Ido, Yasuo

“…Dysregulated autophagy and decreased AMP-activated protein kinase (AMPK) activity are each associated with atherogenesis. Atherogenesis is preceded by high…”
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Knockdown of GSK3β increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells by Weikel, Karen A, Cacicedo, José M, Ruderman, Neil B, Ido, Yasuo

“…High concentrations of glucose and palmitate increase endothelial cell inflammation and apoptosis, events that often precede atherogenesis. They may do so by…”
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Nutritional modulation of cataract by Weikel, Karen A, Garber, Caren, Baburins, Alyssa, Taylor, Allen

“…Lens opacification or cataract reduces vision in over 80 million people worldwide and blinds 18 million. These numbers will increase dramatically as both the…”
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Glycation‐altered proteolysis as a pathobiologic mechanism that links dietary glycemic index, aging, and age‐related disease (in nondiabetics) by Uchiki, Tomoaki, Weikel, Karen A., Jiao, Wangwang, Shang, Fu, Caceres, Andrea, Pawlak, Dorota, Handa, James T., Brownlee, Michael, Nagaraj, Ram, Taylor, Allen

“…Summary Epidemiologic studies indicate that the risks for major age‐related debilities including coronary heart disease, diabetes, and age‐related macular…”
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Unraveling the actions of AMP-activated protein kinase in metabolic diseases: Systemic to molecular insights by Weikel, Karen A, Ruderman, Neil B, Cacicedo, José M

“…Abstract AMP-activated protein kinase (AMPK) plays a critical role both in sensing and regulating cellular energy state. In experimental animals, its…”
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Natural history of age-related retinal lesions that precede AMD in mice fed high or low glycemic index diets by Weikel, Karen A, Fitzgerald, Paul, Shang, Fu, Caceres, M Andrea, Bian, Qingning, Handa, James T, Stitt, Alan W, Taylor, Allen

“…Epidemiologic data indicate that people who consume low glycemic index (GI) diets are at reduced risk for the onset and progression of age-related macular…”
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Differential Protection among Fractionated Blueberry Polyphenolic Families against DA-, Aβ42- and LPS-Induced Decrements in Ca2+ Buffering in Primary Hippocampal Cells by Joseph, James A, Shukitt-Hale, Barbara, Brewer, Gregory J, Weikel, Karen A, Kalt, Wilhelmina, Fisher, Derek R

“…It has been postulated that at least part of the loss of cognitive function in aging may be the result of deficits in Ca2+ recovery (CAR) and increased…”
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Dietary Glycemic Index as a Modulator of Age‐Related Macular Degeneration by Weikel, Karen A, Taylor, Allen

“…Age‐related macular degeneration (AMD) is one of the leading causes of blindness in the US. Efficacious treatments are limited, prompting the need for…”
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Differential Protection among Fractionated Blueberry Polyphenolic Families against DA-, Aβ 42 - and LPS-Induced Decrements in Ca 2+ Buffering in Primary Hippocampal Cells by Joseph, James A., Shukitt-Hale, Barbara, Brewer, Gregory J., Weikel, Karen A., Kalt, Wilhelmina, Fisher, Derek R.

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Differential protection among fractionated blueberry polyphenolic families against DA-, Abeta(42)- and LPS-induced decrements in Ca(2+) buffering in primary hippocampal cells by Joseph, James A, Shukitt-Hale, Barbara, Brewer, Gregory J, Weikel, Karen A, Kalt, Wilhelmina, Fisher, Derek R

“…It has been postulated that at least part of the loss of cognitive function in aging may be the result of deficits in Ca(2+) recovery (CAR) and increased…”
Get full text