Search Results - "Weihofen, Wilhelm"

Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction by Sotomayor, Marcos, Weihofen, Wilhelm A., Gaudet, Rachelle, Corey, David P.

“…A combination of structural, computational and biophysical tools is used to characterize the bond between tip-link proteins protocadherin 15 and cadherin 23,…”
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Crystal Structure and Conformational Change Mechanism of a Bacterial Nramp-Family Divalent Metal Transporter by Bozzi, Aaron T., Bane, Lukas B., Weihofen, Wilhelm A., Singharoy, Abhishek, Guillen, Eduardo R., Ploegh, Hidde L., Schulten, Klaus, Gaudet, Rachelle

“…The widely conserved natural resistance-associated macrophage protein (Nramp) family of divalent metal transporters enables manganese import in bacteria and…”
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Conserved methionine dictates substrate preference in Nramp-family divalent metal transporters by Bozzi, Aaron T., Bane, Lukas B., Weihofen, Wilhelm A., McCabe, Anne L., Singharoy, Abhishek, Chipot, Christophe J., Schulten, Klaus, Gaudet, Rachelle

“…Natural resistance-associated macrophage protein (Nramp) family transporters catalyze uptake of essential divalent transition metals like iron and manganese…”
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Structure and Sequence Analyses of Clustered Protocadherins Reveal Antiparallel Interactions that Mediate Homophilic Specificity by Nicoludis, John M., Lau, Sze-Yi, Schärfe, Charlotta P.I., Marks, Debora S., Weihofen, Wilhelm A., Gaudet, Rachelle

“…Clustered protocadherin (Pcdh) proteins mediate dendritic self-avoidance in neurons via specific homophilic interactions in their extracellular cadherin (EC)…”
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Structural Determinants of Cadherin-23 Function in Hearing and Deafness by Sotomayor, Marcos, Weihofen, Wilhelm A., Gaudet, Rachelle, Corey, David P.

“…The hair-cell tip link, a fine filament directly conveying force to mechanosensitive transduction channels, is composed of two proteins, protocadherin-15 and…”
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Scorpion α-toxin LqhαIT specifically interacts with a glycan at the pore domain of voltage-gated sodium channels by Phulera, Swastik, Dickson, Callum J, Schwalen, Christopher J, Khoshouei, Maryam, Cassell, Samantha J, Sun, Yishan, Condos, Tara, Whicher, Jonathan, Weihofen, Wilhelm A

“…Voltage-gated sodium (Nav) channels sense membrane potential and drive cellular electrical activity. The deathstalker scorpion α-toxin LqhαIT exerts a strong…”
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Enzymatic blockade of the ubiquitin-proteasome pathway by Ernst, Robert, Claessen, Jasper H L, Mueller, Britta, Sanyal, Sumana, Spooner, Eric, van der Veen, Annemarthe G, Kirak, Oktay, Schlieker, Christian D, Weihofen, Wilhelm A, Ploegh, Hidde L

“…Ubiquitin-dependent processes control much of cellular physiology. We show that expression of a highly active, Epstein-Barr virus-derived deubiquitylating…”
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Discovery of a ZIP7 inhibitor from a Notch pathway screen by Nolin, Erin, Gans, Sara, Llamas, Luis, Bandyopadhyay, Somnath, Brittain, Scott M., Bernasconi-Elias, Paula, Carter, Kyle P., Loureiro, Joseph J., Thomas, Jason R., Schirle, Markus, Yang, Yi, Guo, Ning, Roma, Guglielmo, Schuierer, Sven, Beibel, Martin, Lindeman, Alicia, Sigoillot, Frederic, Chen, Amy, Xie, Kevin X., Ho, Samuel, Reece-Hoyes, John, Weihofen, Wilhelm A., Tyskiewicz, Kayla, Hoepfner, Dominic, McDonald, Richard I., Guthrie, Nicolette, Dogra, Abhishek, Guo, Haibing, Shao, Jian, Ding, Jian, Canham, Stephen M., Boynton, Geoff, George, Elizabeth L., Kang, Zhao B., Antczak, Christophe, Porter, Jeffery A., Wallace, Owen, Tallarico, John A., Palmer, Amy E., Jenkins, Jeremy L., Jain, Rishi K., Bushell, Simon M., Fryer, Christy J.

“…The identification of activating mutations in NOTCH1 in 50% of T cell acute lymphoblastic leukemia has generated interest in elucidating how these mutations…”
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CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma by Ross, Nathan T., Lohmann, Felix, Carbonneau, Seth, Fazal, Aleem, Weihofen, Wilhelm A., Gleim, Scott, Salcius, Michael, Sigoillot, Frederic, Henault, Martin, Carl, Sarah H., Rodríguez-Molina, Juan B., Miller, Howard R., Brittain, Scott M., Murphy, Jason, Zambrowski, Mark, Boynton, Geoffrey, Wang, Yuan, Chen, Aye, Molind, Gregory J., Wilbertz, Johannes H., Artus-Revel, Caroline G., Jia, Min, Akinjiyan, Favour A., Turner, Jonathan, Knehr, Judith, Carbone, Walter, Schuierer, Sven, Reece-Hoyes, John S., Xie, Kevin, Saran, Chitra, Williams, Eric T., Roma, Guglielmo, Spencer, Matt, Jenkins, Jeremy, George, Elizabeth L., Thomas, Jason R., Michaud, Gregory, Schirle, Markus, Tallarico, John, Passmore, Lori A., Chao, Jeffrey A., Beckwith, Rohan E. J.

“…The post-genomic era has seen many advances inBaryza and G. Rice for helpful our understanding of cancer pathways, yet resistance and tumor heterogeneity…”
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A NMDA-receptor calcium influx assay sensitive to stimulation by glutamate and glycine/D-serine by Guo, Hongqiu, Camargo, L. Miguel, Yeboah, Fred, Digan, Mary Ellen, Niu, Honglin, Pan, Yue, Reiling, Stephan, Soler-Llavina, Gilberto, Weihofen, Wilhelm A., Wang, Hao-Ran, Shanker, Y. Gopi, Stams, Travis, Bill, Anke

“…N-methyl-D-aspartate-receptors (NMDARs) are ionotropic glutamate receptors that function in synaptic transmission, plasticity and cognition. Malfunction of…”
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Structure of a Herpesvirus-Encoded Cysteine Protease Reveals a Unique Class of Deubiquitinating Enzymes by Schlieker, Christian, Weihofen, Wilhelm A., Frijns, Evelyne, Kattenhorn, Lisa M., Gaudet, Rachelle, Ploegh, Hidde L.

“…All members of the herpesviridae contain within their large tegument protein a cysteine protease module that displays deubiquitinating activity. We report the…”
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Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach by Lorthiois, Edwige, Roache, James, Barnes-Seeman, David, Altmann, Eva, Hassiepen, Ulrich, Turner, Gordon, Duvadie, Rohit, Hornak, Viktor, Karki, Rajeshri G, Schiering, Nikolaus, Weihofen, Wilhelm A, Perruccio, Francesca, Calhoun, Amy, Fazal, Tanzina, Dedic, Darija, Durand, Corinne, Dussauge, Solene, Fettis, Kamal, Tritsch, Fabien, Dentel, Celine, Druet, Adelaide, Liu, Donglei, Kirman, Louise, Lachal, Julie, Namoto, Kenji, Bevan, Douglas, Mo, Rose, Monnet, Gabriela, Muller, Lionel, Zessis, Richard, Huang, Xueming, Lindsley, Loren, Currie, Treeve, Chiu, Yu-Hsin, Fridrich, Cary, Delgado, Peter, Wang, Shuangxi, Hollis-Symynkywicz, Micah, Berghausen, Joerg, Williams, Eric, Liu, Hong, Liang, Guiqing, Kim, Hyungchul, Hoffmann, Peter, Hein, Andreas, Ramage, Paul, D’Arcy, Allan, Harlfinger, Stefanie, Renatus, Martin, Ruedisser, Simon, Feldman, David, Elliott, Jason, Sedrani, Richard, Maibaum, Juergen, Adams, Christopher M

“…The serine protease factor XI (FXI) is a prominent drug target as it holds promise to deliver efficacious anticoagulation without an enhanced risk of major…”
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Streptococcus pyogenes pSM19035 requires dynamic assembly of ATP-bound ParA and ParB on parS DNA during plasmid segregation by Pratto, Florencia, Cicek, Aslan, Weihofen, Wilhelm A, Lurz, Rudi, Saenger, Wolfram, Alonso, Juan C

“…The accurate partitioning of Firmicute plasmid pSM19035 at cell division depends on ATP binding and hydrolysis by homodimeric ATPase δ₂ (ParA) and binding of…”
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Characterization and Structural Studies of the Plasmodium falciparum Ubiquitin and Nedd8 Hydrolase UCHL3 by Artavanis-Tsakonas, Katerina, Weihofen, Wilhelm A., Antos, John M., Coleman, Bradley I., Comeaux, Christy A., Duraisingh, Manoj T., Gaudet, Rachelle, Ploegh, Hidde L.

“…Like their human hosts, Plasmodium falciparum parasites rely on the ubiquitin-proteasome system for survival. We previously identified PfUCHL3, a…”
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Scaffold Morphing Identifies 3‑Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT) by Palacios, Daniel S, Meredith, Erik L, Kawanami, Toshio, Adams, Christopher M, Chen, Xin, Darsigny, Veronique, Palermo, Mark, Baird, Daniel, George, Elizabeth L, Guy, Chantale, Hewett, Jeffrey, Tierney, Laryssa, Thigale, Sachin, Wang, Louis, Weihofen, Wilhelm A

“…Small molecules that inhibit the metabolic enzyme NAMPT have emerged as potential therapeutics in oncology. As part of our effort in this area, we took a…”
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Author Correction: CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma by Ross, Nathan T., Lohmann, Felix, Carbonneau, Seth, Fazal, Aleem, Weihofen, Wilhelm A., Gleim, Scott, Salcius, Michael, Sigoillot, Frederic, Henault, Martin, Carl, Sarah H., Rodríguez-Molina, Juan B., Miller, Howard R., Brittain, Scott M., Murphy, Jason, Zambrowski, Mark, Boynton, Geoffrey, Wang, Yuan, Chen, Aye, Molind, Gregory J., Wilbertz, Johannes H., Artus-Revel, Caroline G., Jia, Min, Akinjiyan, Favour A., Turner, Jonathan, Knehr, Judith, Carbone, Walter, Schuierer, Sven, Reece-Hoyes, John S., Xie, Kevin, Saran, Chitra, Williams, Eric T., Roma, Guglielmo, Spencer, Matt, Jenkins, Jeremy, George, Elizabeth L., Thomas, Jason R., Michaud, Gregory, Schirle, Markus, Tallarico, John, Passmore, Lori A., Chao, Jeffrey A., Beckwith, Rohan E. J.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Crystal Structure of CD26/Dipeptidyl-peptidase IV in Complex with Adenosine Deaminase Reveals a Highly Amphiphilic Interface by Weihofen, Wilhelm A, Liu, Jiango, Reutter, Werner, Saenger, Wolfram, Fan, Hua

“…Dipeptidyl-peptidase IV (DPPIV or CD26) is a homodimeric type II membrane glycoprotein in which the two monomers are subdivided into a β-propeller domain and…”
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Structures of Human N-Acetylglucosamine Kinase in Two Complexes with N-Acetylglucosamine and with ADP/Glucose: Insights into Substrate Specificity and Regulation by Weihofen, Wilhelm A., Berger, Markus, Chen, Hao, Saenger, Wolfram, Hinderlich, Stephan

“…N-Acetylglucosamine (GlcNAc), a major component of complex carbohydrates, is synthesized de novo or salvaged from lysosomally degraded glycoconjugates and from…”
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A capillary‐based microfluidic device enables primary high‐throughput room‐temperature crystallographic screening by Sui, Shuo, Mulichak, Anne, Kulathila, Raviraj, McGee, Joshua, Filiatreault, Danny, Saha, Sarthak, Cohen, Aina, Song, Jinhu, Hung, Holly, Selway, Jonathan, Kirby, Christina, Shrestha, Om K., Weihofen, Wilhelm, Fodor, Michelle, Xu, Mei, Chopra, Rajiv, Perry, Sarah L.

“…A novel capillary‐based microfluidic strategy to accelerate the process of small‐molecule‐compound screening by room‐temperature X‐ray crystallography using…”
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Crystal Structures of HIV-1 Tat-derived Nonapeptides Tat-(1–9) and Trp2-Tat-(1–9) Bound to the Active Site of Dipeptidyl-peptidase IV (CD26) by Weihofen, Wilhelm Andreas, Liu, Jianguo, Reutter, Werner, Saenger, Wolfram, Fan, Hua

“…CD26 or dipeptidyl-peptidase IV (DPPIV) is engaged in immune functions by co-stimulatory effects on activation and proliferation of T lymphocytes, binding to…”
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