Search Results - "Weigert, Martin G."

LAPTM5 mediates immature B cell apoptosis and B cell tolerance by regulating the WWP2-PTEN-AKT pathway by Wang, Ying, Liu, Jun, Akatsu, Chizuru, Zhang, Runyun, Zhang, Hai, Zhu, Han, Liu, Kangwei, Zhu, Han-Ying, Min, Qing, Meng, Xin, Cui, Chaoqun, Tang, Yue, Yu, Meiping, Li, Yaxuan, Feng, Xiaoqian, Wei, Hao, Wen, Zichao, Ji, Sihan, Weigert, Martin G, Tsubata, Takeshi, Wang, Ji-Yang

“…Elimination of autoreactive developing B cells is an important mechanism to prevent autoantibody production. However, how B cell receptor (BCR) signaling…”
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Alternative mechanisms of receptor editing in autoreactive B cells by Kalinina, Olga, Doyle-Cooper, Colleen M., Miksanek, Jennifer, Meng, Wenzhao, Prak, Eline Luning, Weigert, Martin G.

“…Pathogenic anti-DNA antibodies expressed in systemic lupus erythematosis bind DNA mainly through electrostatic interactions between the positively charged Arg…”
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Apoptotic marginal zone deletion of anti-Sm/ribonucleoprotein B cells by Kishi, Yusuke, Higuchi, Tetsuya, Phoon, Shirly, Sakamaki, Yasuo, Kamiya, Koki, Riemekasten, Gabriela, Akiyoshi, Kazunari, Weigert, Martin G., Tsubata, Takeshi

“…CD40L is excessively produced in both human and murine lupus and plays a role in lupus pathogenesis. To address how excess CD40L induces autoantibody…”
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Antibodies that bind complex glycosaminoglycans accumulate in the Golgi by Radie, Marko, Weigert, Martin G., Khan, Salar N., Han, Jiong, Kalinina, Olga, Prak, Eline T. Luning

“…Light (L) chains that edit anti-DNA heavy (H) chains rescue B-cell development by suppressing DNA binding. However, exceptional editor L chains allow B cells…”
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Development and Selection of Edited B Cells in B6.56R Mice by Sekiguchi, Debora R, Yunk, Lenka, Gary, David, Charan, Deepshikha, Srivastava, Bhaskar, Allman, David, Weigert, Martin G, Prak, Eline T. Luning

“…Tolerance to dsDNA is broken in mice with a high-affinity anti-DNA H chain transgene, 56R, on the C57BL/6 background (B6.56R). B6.56R produce more anti-dsDNA…”
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Consequences of Receptor Editing at the λ Locus: Multireactivity and Light Chain Secretion by Doyle, Colleen M., Han, Jiong, Weigert, Martin G., Prak, Eline T. Luning

“…To investigate the manner in which B cells with λ light (L) chains undergo receptor editing, we have studied hybridoma panels from 56R/κ-deleted (kdel) mice…”
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The role of clonal selection and somatic mutation in autoimmunity by Shlomchik, Mark J, Marshak-Rothstein, Ann, Wolfowicz, Claudia B, Rothstein, Thomas L, Weigert, Martin G

“…Polyclonal activation has been proposed as the reason that autoantibodies are produced during autoimmune disease. This model denies a role for specific antigen…”
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Selection of individual VH genes occurs at the pro-B to pre-B cell transition by Meng, Wenzhao, Yunk, Lenka, Wang, Li-San, Maganty, Avinash, Xue, Emily, Cohen, Philip L, Eisenberg, Robert A, Weigert, Martin G, Mancini, Stephane J C, Prak, Eline T Luning

“…B cells are subjected to selection at multiple checkpoints during their development. The selection of Ab H chains is difficult to study because of the large…”
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Selection of individual V$_H$ genes occurs at the pro-B to pre-B cell transition by Meng, Wenzhao, Yunk, Lenka, Wang, Li-San, Maganty, Avinash, Xue, Emily, Cohen, Philip L, Eisenberg, Robert A, Weigert, Martin G, Mancini, Stephane J C, Prak, Eline T Luning

“…B cells are subjected to selection at multiple checkpoints during their development. The selection of Ab H chains is difficult to study because of the large…”
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Variability in the Lambda Light Chain Sequences of Mouse Antibody by WEIGERT, MARTIN G, CESARI, ITALO M, YONKOVICH, SHIRLEE J, COHN, MELVIN

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Activation-Induced Cytidine Deaminase (AID) Can Target Both DNA Strands When the DNA Is Supercoiled by Shen, Hong Ming, Storb, Ursula, Weigert, Martin G.

“…The activation-induced cytidine deaminase (AID) is required for somatic hypermutation (SHM) and class-switch recombination of Ig genes. It has been shown that…”
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The Evolution of Human Anti-Double-Stranded DNA Autoantibodies by Wellmann, Ute, Letz, Miriam, Herrmann, Martin, Angermüller, Sieglinde, Kalden, Joachim R., Winkler, Thomas H., Weigert, Martin G.

“…It has been proposed that the anti-double-stranded DNA (dsDNA) response in patients with systemic lupus erythematosus (SLE) is antigen driven and that DNA or…”
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Base Composition of Nonsense Condons in E. coli : Evidence from Amino-Acid Substitutions at a Tryptophan Site in Alkaline Phosphatase by WEIGERT, MARTIN G, GAREN, ALAN

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Genome-Wide Somatic Hypermutation by Wang, Clifford L., Harper, Ryan A., Wabl, Matthias, Weigert, Martin G.

“…DNA mutagenesis is generally considered harmful. Yet activated B cells normally mutate the Ig loci. Because this somatic hypermutation is potentially…”
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Early onset of autoimmune disease by the retroviral integrase inhibitor raltegravir by Beck-Engeser, Gabriele B, Eilat, Dan, Harrer, Thomas, Jäck, Hans-Martin, Wabl, Matthias

“…Raltegravir is a recently, Food and Drug Administration-approved, small-molecule drug that inhibits retroviral integrase, thereby preventing HIV DNA from…”
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Endocytic sequestration of the B cell antigen receptor and toll-like receptor 9 in anergic cells by O'Neill, Shannon K, Veselits, Margaret L, Zhang, Miao, Labno, Christine, Cao, Yanxia, Finnegan, Alison, Uccellini, Melissa, Alegre, Maria-Luisa, Cambier, John C, Clark, Marcus R

“…In autoimmune prone murine strains, sequential engagement of the B cell antigen receptor (BCR) on the cell surface and toll-like receptors (TLRs) in late…”
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Autoreactivity in an HIV-1 Broadly Reactive Neutralizing Antibody Variable Region Heavy Chain Induces Immunologie Tolerance by Verkoczy, Laurent, Diaz, Marilyn, Holl, T. Matt, Ouyang, Ying-Bin, Bouton-Verville, Hilary, Alam, S. Munir, Liao, Hua-Xin, Kelsoe, Garnett, Haynes, Barton F., Weigert, Martin G.

“…We previously reported that some of the rare broadly reactive, HIV-1 neutralizing antibodies are polyreactive, leading to the hypothesis that induction of…”
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Consequences of receptor editing at the [lamda] locus: Multireactivity and light chain secretion by Doyle, Colleen M, Han, Jiong, Weigert, Martin G, Eline T Luning Prak

“…To investigate the manner in which B cells with λ light (L) chains undergo receptor editing, we have studied hybridoma panels from 56R/κ-deleted (kdel) mice…”
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A disease-related rheumatoid factor autoantibody is not tolerized in a normal mouse: implications for the origins of autoantibodies in autoimmune disease by Hannum, L G, Ni, D, Haberman, A M, Weigert, M G, Shlomchik, M J

“…We have analyzed B cell tolerance in a rheumatoid factor (RF) transgenic mouse model. The model is based on AM14, a hybridoma, originally isolated from an…”
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Structure and Function of Anti-DNA Autoantibodies Derived from a Single Autoimmune Mouse by Shlomchik, Mark J., Aucoin, Ann H., Pisetsky, David S., Weigert, Martin G.

“…Four monoclonal anti-DNA antibodies derived from a single autoimmune MRL/lpr mouse were studied. Three of these antibodies showed similarities in DNA binding;…”
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