Search Results - "Weigand, Stefan"

2-Pyridylmetallocenes, Part IX. Sulphur-Substituted 2-Pyridylferrocene: Synthesis and Reactivity towards Pt(II) and Hg(II) by Weigand, Stefan, Sünkel, Karlheinz

“…Thio-substituted 2-pyridylferrocenes [CpFe{C H (X)(C H N)}] (X = SOTol, ; SMe, ) were prepared from [CpFe(C H R)] (R = SOTol, ; 2-C H N, ) in moderate yields…”
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Antibacterial Natural Products in Medicinal Chemistry-Exodus or Revival? by von Nussbaum, Franz, Brands, Michael, Hinzen, Berthold, Weigand, Stefan, Häbich, Dieter

“…To create a drug, nature's blueprints often have to be improved through semisynthesis or total synthesis (chemical postevolution). Selected contributions from…”
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Chlorido-pentamethylcyclopentadienyl-[2-(2-pyridyl-кN)-ferrocenyl-кC]-iridium(III) by Weigand, Stefan, Sünkel, Karlheinz

“…Treatment of 2-pyridyl-ferrocene wit [Cp*IrCl2]2 in the presence of NaOAc produces the title compound Cp*ClIr[(C5H3C5H4N-кN,кC)Fe(C5H5)] (2) in low yield. A…”
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Evidence for “Halogen‐Dance” and Ring‐Exchange Reactions in Chloro‐methylthio‐ferrocenes by Blockhaus, Tobias, Bernhartzeder, Stefanie, Kempinger, Werner, Klein‐Heßling, Christian, Weigand, Stefan, Sünkel, Karlheinz

“…The pentachloroferrocenes [C5Cl5]Fe[C5H4X] (X = H, Br, SMe) react with LiTMP and MeSSMe to form mixtures of compounds, that contain besides the expected…”
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Targeting chronic lymphocytic leukemia cells with a humanized monoclonal antibody specific for CD44 by Zhang, Suping, Wu, Christina C. N., Fecteau, Jessie-F., Cui, Bing, Chen, Liguang, Zhang, Ling, Wu, Rongrong, Rassenti, Laura, Lao, Fitzgerald, Weigand, Stefan, Kipps, Thomas J.

“…Chronic lymphocytic leukemia (CLL) cells express high levels of CD44, a cell-surface glycoprotein receptor for hyaluronic acid. We found that a humanized mAb…”
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Targeting Tumor Cells with Anti-CD44 Antibody Triggers Macrophage-Mediated Immune Modulatory Effects in a Cancer Xenograft Model by Maisel, Daniela, Birzele, Fabian, Voss, Edgar, Nopora, Adam, Bader, Sabine, Friess, Thomas, Goller, Bernhard, Laifenfeld, Daphna, Weigand, Stefan, Runza, Valeria

“…CD44, a transmembrane receptor reported to be involved in various cellular functions, is overexpressed in several cancer types and supposed to be involved in…”
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Discovery of Riociguat (BAY 63-2521): A Potent, Oral Stimulator of Soluble Guanylate Cyclase for the Treatment of Pulmonary Hypertension by Mittendorf, Joachim, Weigand, Stefan, Alonso-Alija, Cristina, Bischoff, Erwin, Feurer, Achim, Gerisch, Michael, Kern, Armin, Knorr, Andreas, Lang, Dieter, Muenter, Klaus, Radtke, Martin, Schirok, Hartmut, Schlemmer, Karl-Heinz, Stahl, Elke, Straub, Alexander, Wunder, Frank, Stasch, Johannes-Peter

“…Direct stimulation of soluble guanylate cyclase (sGC) represents a promising therapeutic strategy for the treatment of a range of diseases, including the…”
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Characterization of Breast Cancer Preclinical Models Reveals a Specific Pattern of Macrophage Polarization by Vallerand, David, Massonnet, Gérald, Kébir, Fatima, Gentien, David, Maciorowski, Zofia, De la Grange, Pierre, Sigal-Zafrani, Brigitte, Richardson, Marion, Humbert, Sandrine, Thuleau, Aurélie, Assayag, Franck, de Plater, Ludmilla, Nicolas, André, Scholl, Suzy, Marangoni, Elisabetta, Weigand, Stefan, Roman-Roman, Sergio, Savina, Ariel, Decaudin, Didier

“…Drug discovery efforts have focused on the tumor microenvironment in recent years. However, few studies have characterized the stroma component in…”
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2-Pyridylmetallocenes, Part IX. Sulphur-Substituted 2-Pyridylferrocene: Synthesis and Reactivity towards Pt by Weigand, Stefan, Sünkel, Karlheinz

“…Thio-substituted 2-pyridylferrocenes [CpFe{C[sub.5]H[sub.3](X)(C[sub.5]H[sub.4]N)}] (X = SOTol, 3; SMe, 5) were prepared from [CpFe(C[sub.5]H[sub.4]R)] (R =…”
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Scalable Synthesis of the Desoxy-biphenomycin B Core by Berwe, Mathias, Jöntgen, Winfried, Krüger, Jochen, Cancho-Grande, Yolanda, Lampe, Thomas, Michels, Martin, Paulsen, Holger, Raddatz, Siegfried, Weigand, Stefan

“…We describe the evolution of a kilogram-scale synthesis of the protected cyclic tripeptide desoxy-biphenomycin B, based on an early discovery route. The…”
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Chlorido-pentamethylcyclopentadienyl-[2 by Weigand, Stefan, Sünkel, Karlheinz

“…Treatment of 2-pyridyl-ferrocene wit [Cp*IrCl[sub.2]][sub.2] in the presence of NaOAc produces the title compound…”
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2‐Pyridylmetallocenes, Part VII. Synthesis and Crystal Structures of Cycloaurated Pyridylmetallocenes by Weigand, Stefan, Sünkel, Karlheinz

“…Treatment of the 2‐pyridylferrocenes [CpFe(C5H3R{C5H4N})] (R=H, Me) with HAuCl4 or NaAuCl4 in aqueous acetonitrile yields the cycloaurated complexes…”
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Chiral Recognition for Control of Alkene Geometry in a Transition Metal Catalyzed Allylic Alkylation by Trost, Barry M, Heinemann, Christoph, Ariza, Xavier, Weigand, Stefan

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Evaluation of higher order sound particle diffraction with measurements around finite sized screens in a semi-anechoic chamber by Weigand, Stefan, Aspöck, Lukas, Stephenson, Uwe M.

“…Noise prediction and room acoustic design rely on simulation methods to model sound propagation. The sound particle simulation method (SPSM), among others, is…”
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2-Pyridylmetallocenes: Part I. Electrophilic halogenation of 2-pyridylferrocene. Molecular structures of 2-pyridylferrocene and its α-brominated and -fluorinated derivatives. Synthesis of 2-pyridylruthenocene and 2-pyridylcymantrene by Sünkel, Karlheinz, Weigand, Stefan

“…New high-yield syntheses of the 2-pyridylmetallocenes [C 5H 4(2-C 5H 4N)]ML n (ML n = FeCp ( 1), RuCp ( 2), Mn(CO) 3 ( 3)) are reported. Lithiation of 1…”
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First-in-human phase I clinical trial of RG7356, an anti-CD44 humanized antibody, in patients with advanced, CD44-expressing solid tumors by Menke-van der Houven van Oordt, C Willemien, Gomez-Roca, Carlos, van Herpen, Carla, Coveler, Andrew L, Mahalingam, Devalingam, Verheul, Henk M W, van der Graaf, Winette T A, Christen, Randolph, Rüttinger, Dominik, Weigand, Stefan, Cannarile, Michael A, Heil, Florian, Brewster, Michael, Walz, Antje-Christine, Nayak, Tapan K, Guarin, Ernesto, Meresse, Valerie, Le Tourneau, Christophe

“…Transmembrane glycoprotein CD44 is overexpressed in various malignancies. Interactions between CD44 and hyaluronic acid are associated with poor prognosis,…”
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Global Quantitative Phosphoproteome Analysis of Human Tumor Xenografts Treated with a CD44 Antagonist by WEIGAND, Stefan, HERTING, Frank, MAISEL, Daniela, NOPORA, Adam, VOSS, Edgar, SCHAAB, Christoph, KLAMMER, Martin, TEBBE, Andreas

“…The cell surface glycoprotein CD44 plays an important role in the development and progression of various tumor types. RG7356 is a humanized antibody targeting…”
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Synthesis and Characterization of 1,2,3,4,5-Pentafluoroferrocene by Sünkel, Karlheinz, Weigand, Stefan, Hoffmann, Alexander, Blomeyer, Sebastian, Reuter, Christian G, Vishnevskiy, Yury V, Mitzel, Norbert W

“…Starting from ferrocene, pentafluoroferrocene [Fe­(C5F5)­(C5H5)] can be prepared in five steps via a one-pot lithiation–electrophilic fluorination strategy…”
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2-Pyridylmetallocenes: Part 3 [1]. Cyclomercuration of 2-pyridyl-ferrocene and 1-(2-pyridyl)-2-methyl-ferrocene. Molecular structures of [1-(2-C5H4N)-2-(CH3)C5H3]Fe(C5H5), [1-(ClHg)-2-(2-C5H4N)C5H3]Fe(C5H5) and [1-(ClHg)-2-(2-C5H4N)-3-(CH3)C5H2]Fe(C5H5) by Sünkel, Karlheinz, Weigand, Stefan

“…The 2-pyridyl metallocenes [(2-C5H4N)(R)C5H3]Fe(C5H5) (R=H, Me) can be mercurated by Hg(OAc)2/LiCl to give the corresponding cyclomercurated compounds…”
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CD44 Isoform Status Predicts Response to Treatment with Anti-CD44 Antibody in Cancer Patients by Birzele, Fabian, Voss, Edgar, Nopora, Adam, Honold, Konrad, Heil, Florian, Lohmann, Sabine, Verheul, Henk, Le Tourneau, Christophe, Delord, Jean-Pierre, van Herpen, Carla, Mahalingam, Devalingam, Coveler, Andrew L, Meresse, Valerie, Weigand, Stefan, Runza, Valeria, Cannarile, Michael

“…CD44, a cell surface glycoprotein, plays important roles in the development, progression, and metastasis of various tumor types. The aim of this study was to…”
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