Search Results - "Weibezahn, Jimena"

A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress by Brandman, Onn, Stewart-Ornstein, Jacob, Wong, Daisy, Larson, Adam, Williams, Christopher C., Li, Gene-Wei, Zhou, Sharleen, King, David, Shen, Peter S., Weibezahn, Jimena, Dunn, Joshua G., Rouskin, Silvi, Inada, Toshifumi, Frost, Adam, Weissman, Jonathan S.

“…The conserved transcriptional regulator heat shock factor 1 (Hsf1) is a key sensor of proteotoxic and other stress in the eukaryotic cytosol. We surveyed Hsf1…”
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Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum by Jonikas, Martin C, Collins, Sean R, Denic, Vladimir, Oh, Eugene, Quan, Erin M, Schmid, Volker, Weibezahn, Jimena, Schwappach, Blanche, Walter, Peter, Weissman, Jonathan S, Schuldiner, Maya

“…Protein folding in the endoplasmic reticulum is a complex process whose malfunction is implicated in disease and aging. By using the cell's endogenous sensor…”
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A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility by Bassik, Michael C., Kampmann, Martin, Lebbink, Robert Jan, Wang, Shuyi, Hein, Marco Y., Poser, Ina, Weibezahn, Jimena, Horlbeck, Max A., Chen, Siyuan, Mann, Matthias, Hyman, Anthony A., LeProust, Emily M., McManus, Michael T., Weissman, Jonathan S.

“…Genetic interaction (GI) maps, comprising pairwise measures of how strongly the function of one gene depends on the presence of a second, have enabled the…”
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Defining the Glycan Destruction Signal for Endoplasmic Reticulum-Associated Degradation by Quan, Erin M., Kamiya, Yukiko, Kamiya, Daiki, Denic, Vladimir, Weibezahn, Jimena, Kato, Koichi, Weissman, Jonathan S.

“…The endoplasmic reticulum (ER) must target potentially toxic misfolded proteins for retrotranslocation and proteasomal degradation while avoiding destruction…”
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The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins by Shurtleff, Matthew J, Itzhak, Daniel N, Hussmann, Jeffrey A, Schirle Oakdale, Nicole T, Costa, Elizabeth A, Jonikas, Martin, Weibezahn, Jimena, Popova, Katerina D, Jan, Calvin H, Sinitcyn, Pavel, Vembar, Shruthi S, Hernandez, Hilda, Cox, Jürgen, Burlingame, Alma L, Brodsky, Jeffrey L, Frost, Adam, Borner, Georg Hh, Weissman, Jonathan S

“…The endoplasmic reticulum (ER) supports biosynthesis of proteins with diverse transmembrane domain (TMD) lengths and hydrophobicity. Features in transmembrane…”
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Thermotolerance Requires Refolding of Aggregated Proteins by Substrate Translocation through the Central Pore of ClpB by Weibezahn, Jimena, Tessarz, Peter, Schlieker, Christian, Zahn, Regina, Maglica, Zeljka, Lee, Sukyeong, Zentgraf, Hanswalter, Weber-Ban, Eilika U., Dougan, David A., Tsai, Francis T.F., Mogk, Axel, Bukau, Bernd

“…Cell survival under severe thermal stress requires the activity of the ClpB (Hsp104) AAA+ chaperone that solubilizes and reactivates aggregated proteins in…”
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Roles of Individual Domains and Conserved Motifs of the AAA+ Chaperone ClpB in Oligomerization, ATP Hydrolysis, and Chaperone Activity by Mogk, Axel, Schlieker, Christian, Strub, Christine, Rist, Wolfgang, Weibezahn, Jimena, Bukau, Bernd

“…ClpB of Escherichia coli is an ATP-dependent ring-forming chaperone that mediates the resolubilization of aggregated proteins in cooperation with the DnaK…”
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Substrate recognition by the AAA+ chaperone ClpB by Bukau, Bernd, Mogk, Axel, Schlieker, Christian, Weibezahn, Jimena, Patzelt, Holger, Tessarz, Peter, Strub, Christine, Zeth, Kornelius, Erbse, Annette, Schneider-Mergener, Jens, Chin, Jason W, Schultz, Peter G

“…The AAA+ protein ClpB cooperates with the DnaK chaperone system to solubilize and refold proteins from an aggregated state. The substrate-binding site of ClpB…”
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Characterization of a Trap Mutant of the AAA+ Chaperone ClpB by Weibezahn, Jimena, Schlieker, Christian, Bukau, Bernd, Mogk, Axel

“…The AAA+ protein ClpB mediates the solubilization of protein aggregates in cooperation with the DnaK chaperone system (KJE). The order of action of ClpB and…”
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Unscrambling an egg: protein disaggregation by AAA+ proteins by Weibezahn, Jimena, Bukau, Bernd, Mogk, Axel

“…Aprotein quality control system, consisting of molecular chaperones and proteases, controls the folding status of proteins and prevents the aggregation of…”
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Genome-wide mRNA profiling in glucose starved Bacillus subtilis cells by Koburger, Torsten, Weibezahn, Jimena, Bernhardt, Jörg, Homuth, Georg, Hecker, M

“…In this study global changes in gene expression were monitored in Bacillus subtilis cells entering stationary growth phase owing to starvation for glucose…”
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Functional Repurposing Revealed by Comparing S. pombe and S. cerevisiae Genetic Interactions by Frost, Adam, Elgort, Marc G., Brandman, Onn, Ives, Clinton, Collins, Sean R., Miller-Vedam, Lakshmi, Weibezahn, Jimena, Hein, Marco Y., Poser, Ina, Mann, Matthias, Hyman, Anthony A., Weissman, Jonathan S.

“…We present a genetic interaction map of pairwise measures including ∼40% of nonessential S. pombe genes. By comparing interaction maps for fission and budding…”
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M Domains Couple the ClpB Threading Motor with the DnaK Chaperone Activity by Haslberger, Tobias, Weibezahn, Jimena, Zahn, Regina, Lee, Sukyeong, Tsai, Francis T.F., Bukau, Bernd, Mogk, Axel

“…The AAA+ chaperone ClpB mediates the reactivation of aggregated proteins in cooperation with the DnaK chaperone system. ClpB consists of two AAA domains that…”
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Bacillus subtilis during feast and famine: visualization of the overall regulation of protein synthesis during glucose starvation by proteome analysis by Bernhardt, Jörg, Weibezahn, Jimena, Scharf, Christian, Hecker, Michael

“…Dual channel imaging and warping of two-dimensional (2D) protein gels were used to visualize global changes of the gene expression patterns in growing Bacillus…”
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Novel insights into the mechanism of chaperone-assisted protein disaggregation by Weibezahn, Jimena, Schlieker, Christian, Tessarz, Peter, Mogk, Axel, Bukau, Bernd

“…Cell survival under severe thermal stress requires the activity of a bi-chaperone system, consisting of the ring-forming AAA+ chaperone ClpB (Hsp104) and the…”
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Comparing S. pombe and S. cerevisiae Genetic Interactions Reveals Functional Repurposing and Identifies New Organelle Homeostasis and Mitosis Control Genes by Frost, Adam, Elgort, Marc G., Brandman, Onn, Ives, Clinton, Collins, Sean R., Miller-Vedam, Lakshmi, Weibezahn, Jimena, Hein, Marco Y., Poser, Ina, Mann, Matthias, Hyman, Anthony A., Weissman, Jonathan S.

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Broad yet high substrate specificity: the challenge of AAA+ proteins by Mogk, Axel, Dougan, David, Weibezahn, Jimena, Schlieker, Christian, Turgay, Kursad, Bukau, Bernd

“…AAA+ proteins remodel target substrates in an ATP-dependent manner, an activity that is of central importance for a plethora of cellular processes. While…”
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