Search Results - "Wei-Chieh Chiang"

ER stress and unfolded protein response in ocular health and disease by Kroeger, Heike, Chiang, Wei‐Chieh, Felden, Julia, Nguyen, Amanda, Lin, Jonathan H.

“…The human eye is the organ that is able to react to light in order to provide sharp three‐dimensional and colored images. Unfortunately, the health of the eye…”
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Multiple Mechanisms of Unfolded Protein Response–Induced Cell Death by Hiramatsu, Nobuhiko, Chiang, Wei-Chieh, Kurt, Timothy D, Sigurdson, Christina J, Lin, Jonathan H

“…Eukaryotic cells fold and assemble membrane and secreted proteins in the endoplasmic reticulum (ER), before delivery to other cellular compartments or the…”
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The unfolded protein response regulator ATF6 promotes mesodermal differentiation by Kroeger, Heike, Grimsey, Neil, Paxman, Ryan, Chiang, Wei-Chieh, Plate, Lars, Jones, Ying, Shaw, Peter X, Trejo, JoAnn, Tsang, Stephen H, Powers, Evan, Kelly, Jeffery W, Wiseman, R Luke, Lin, Jonathan H

“…encodes a transcription factor that is anchored in the endoplasmic reticulum (ER) and activated during the unfolded protein response (UPR) to protect cells…”
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Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration by Chiang, Wei-Chieh, Kroeger, Heike, Sakami, Sanae, Messah, Carissa, Yasumura, Douglas, Matthes, Michael T., Coppinger, Judith A., Palczewski, Krzysztof, LaVail, Matthew M., Lin, Jonathan H.

“…Rhodopsin is a G protein-coupled receptor essential for vision and rod photoreceptor viability. Disease-associated rhodopsin mutations, such as P23H rhodopsin,…”
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Network biology analysis of P23H rhodopsin interactome identifies protein and mRNA quality control mechanisms by Kim, Kyle, Safarta, Lance A., Chiang, Wei-Chieh J., Coppinger, Judith A., Lee, Eun-Jin, Lin, Jonathan H.

“…Rhodopsin is essential for phototransduction, and many rhodopsin mutations cause heritable retinal degenerations. The P23H rhodopsin variant generates a…”
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IRE1 directs proteasomal and lysosomal degradation of misfolded rhodopsin by Chiang, Wei-Chieh, Messah, Carissa, Lin, Jonathan H

“…Endoplasmic reticulum (ER) is responsible for folding of secreted and membrane proteins in eukaryotic cells. Disruption of ER protein folding leads to ER…”
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Selective activation of ATF6 and PERK endoplasmic reticulum stress signaling pathways prevent mutant rhodopsin accumulation by Chiang, Wei-Chieh, Hiramatsu, Nobuhiko, Messah, Carissa, Kroeger, Heike, Lin, Jonathan H

“…Many rhodopsin mutations that cause retinitis pigmentosa produce misfolded rhodopsin proteins that are retained within the endoplasmic reticulum (ER) and cause…”
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A 45 nm Stacked CMOS Image Sensor Process Technology for Submicron Pixel by Takahashi, Seiji, Huang, Yi-Min, Sze, Jhy-Jyi, Wu, Tung-Ting, Guo, Fu-Sheng, Hsu, Wei-Cheng, Tseng, Tung-Hsiung, Liao, King, Kuo, Chin-Chia, Chen, Tzu-Hsiang, Chiang, Wei-Chieh, Chuang, Chun-Hao, Chou, Keng-Yu, Chung, Chi-Hsien, Chou, Kuo-Yu, Tseng, Chien-Hsien, Wang, Chuan-Joung, Yaung, Dun-Nien

“…A submicron pixel's light and dark performance were studied by experiment and simulation. An advanced node technology incorporated with a stacked CMOS image…”
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The effects of IRE1, ATF6, and PERK signaling on adRP-linked rhodopsins by Jerry Chiang, Wei-Chieh, Lin, Jonathan H

“…Many mutations in rhodopsin gene linked to retinitis pigmentosa (RP) cause rhodopsin misfolding. Rod photoreceptor cells expressing misfolded rhodopsin…”
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De Novo Prion Aggregates Trigger Autophagy in Skeletal Muscle by Joshi-Barr, Shivanjali, Bett, Cyrus, Chiang, Wei-Chieh, Trejo, Margarita, Goebel, Hans H, Sikorska, Beata, Liberski, Pawel, Raeber, Alex, Lin, Jonathan H, Masliah, Eliezer, Sigurdson, Christina J

“…Classifications Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Transmembrane domain interactions affect the stability of the extracellular domain of the human NTPDase 2 by Chiang, Wei-Chieh, Knowles, Aileen F.

“…Human NTPDase2 and chicken NTPDase8 are cell surface nucleotidases that contain two transmembrane domains (TMD) and five apyrase conserved regions (ACRs). ACR1…”
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Multiexon deletion alleles of ATF6 linked to achromatopsia by Lee, Eun-Jin, Chiang, Wei-Chieh Jerry, Kroeger, Heike, Bi, Chloe Xiaoke, Chao, Daniel L, Skowronska-Krawczyk, Dorota, Mastey, Rebecca R, Tsang, Stephen H, Chea, Leon, Kim, Kyle, Lambert, Scott R, Grandjean, Julia Md, Baumann, Britta, Audo, Isabelle, Kohl, Susanne, Moore, Anthony T, Wiseman, R Luke, Carroll, Joseph, Lin, Jonathan H

“…Achromatopsia (ACHM) is an autosomal recessive disease that results in severe visual loss. Symptoms of ACHM include impaired visual acuity, nystagmus, and…”
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Endoplasmic reticulum stress in human photoreceptor diseases by Chan, Priscilla, Stolz, Julia, Kohl, Susanne, Chiang, Wei-Chieh, Lin, Jonathan H

“…Abstract Photoreceptors are specialized sensory neurons essential for light detection in the human eye. Photoreceptor cell dysfunction and death cause vision…”
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Enzymatic and transcriptional regulation of human ecto-ATPase/E-NTPDase 2 by Knowles, Aileen F, Chiang, Wei-Chieh

“…We have characterized the regulation of expressed human ecto-ATPase (E-NTPDase 2), a cell surface integral membrane glycoprotein. Ecto-ATPase activity is…”
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Male germ cell-associated kinase is required for axoneme formation during ciliogenesis in zebrafish photoreceptors by Chiang, Hung-Ju, Nishiwaki, Yuko, Chiang, Wei-Chieh, Masai, Ichiro

“…Vertebrate photoreceptors are highly specialized retinal neurons that have cilium-derived membrane organelles called outer segments, which function as…”
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ATF6 is essential for human cone photoreceptor development by Kroeger, Heike, Grandjean, Julia M. D., Chiang, Wei-Chieh Jerry, Bindels, Daphne D., Mastey, Rebecca, Okalova, Jennifer, Nguyen, Amanda, Powers, Evan T., Kelly, Jeffery W., Grimsey, Neil J., Michaelides, Michel, Carroll, Joseph, Wiseman, R. Luke, Lin, Jonathan H.

“…Endoplasmic reticulum (ER) stress and Unfolded Protein Response (UPR) signaling promote the pathology of many human diseases. Loss-of-function variants of the…”
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Achromatopsia mutations target sequential steps of ATF6 activation by Chiang, Wei-Chieh, Chan, Priscilla, Wissinger, Bernd, Vincent, Ajoy, Skorczyk-Werner, Anna, Krawczyński, Maciej R., Kaufman, Randal J., Tsang, Stephen H., Héon, Elise, Kohl, Susanne, Lin, Jonathan H.

“…Achromatopsia is an autosomal recessive disorder characterized by cone photoreceptor dysfunction. We recently identified activating transcription factor 6…”
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Pathomechanisms of ATF6-Associated Cone Photoreceptor Diseases by Chiang, Wei-Chieh Jerry, Kroeger, Heike, Chea, Lulu, Lin, Jonathan H

“…Activating transcription factor 6 (ATF6) is a key regulator of the unfolded protein response (UPR). In response to endoplasmic reticulum (ER) stress, ATF6 is…”
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Autosomal recessive cone-rod dystrophy can be caused by mutations in the ATF6 gene by Skorczyk-Werner, Anna, Chiang, Wei-Chieh, Wawrocka, Anna, Wicher, Katarzyna, Jarmuż-Szymczak, Małgorzata, Kostrzewska-Poczekaj, Magdalena, Jamsheer, Aleksander, Płoski, Rafał, Rydzanicz, Małgorzata, Pojda-Wilczek, Dorota, Weisschuh, Nicole, Wissinger, Bernd, Kohl, Susanne, Lin, Jonathan H, Krawczyński, Maciej R

“…Inherited retinal dystrophies (IRDs) are clinically and genetically highly heterogeneous, making clinical diagnosis difficult. The advances in high-throughput…”
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Induction of endoplasmic reticulum stress genes, BiP and chop, in genetic and environmental models of retinal degeneration by Kroeger, Heike, Messah, Carissa, Ahern, Kelly, Gee, Jason, Joseph, Victory, Matthes, Michael T, Yasumura, Douglas, Gorbatyuk, Marina S, Chiang, Wei-Chieh, LaVail, Matthew M, Lin, Jonathan H

“…Endoplasmic reticulum (ER) stress has been observed in animal models of retinitis pigmentosa expressing P23H rhodopsin. We compared levels of tightly induced…”
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