Search Results - "Weißmüller, Sabrina"

The immunomodulating activity of trimodulin (polyvalent IgM, IgA, IgG solution): a post hoc analysis of the phase II CIGMA trial by Singer, Mervyn, Torres, Antoni, Heinz, Corina C, Weissmüller, Sabrina, Staus, Alexander, Kistner, Steffen, Jakubczyk, Ksenia, Häder, Thomas, Langohr, Patrick, Wartenberg-Demand, Andrea, Schüttrumpf, Jörg, Vincent, Jean-Louis, Welte, Tobias

“…Abstract Background The phase II CIGMA trial performed in 160 patients with severe community-acquired pneumonia (sCAP) found treatment with trimodulin (human…”
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Immunomodulation: Immunoglobulin Preparations Suppress Hyperinflammation in a COVID-19 Model via FcγRIIA and FcαRI by Bohländer, Fabian, Riehl, Dennis, Weißmüller, Sabrina, Gutscher, Marcus, Schüttrumpf, Jörg, Faust, Stefanie

“…The rapid spread of SARS-CoV-2 has induced a global pandemic. Severe forms of COVID-19 are characterized by dysregulated immune response and "cytokine storm"…”
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Multifaceted Tissue-Protective Functions of Polyvalent Immunoglobulin Preparations in Severe Infections—Interactions with Neutrophils, Complement, and Coagulation Pathways by Schmidt, Carolin, Weißmüller, Sabrina, Heinz, Corina C

“…Severe infections induce immune defense mechanisms and initial tissue damage, which produce an inflammatory neutrophil response. Upon dysregulation of these…”
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TGN1412 Induces Lymphopenia and Human Cytokine Release in a Humanized Mouse Model by Weißmüller, Sabrina, Kronhart, Stefanie, Kreuz, Dorothea, Schnierle, Barbara, Kalinke, Ulrich, Kirberg, Jörg, Hanschmann, Kay-Martin, Waibler, Zoe

“…Therapeutic monoclonal antibodies (mAbs) such as the superagonistic, CD28-specific antibody TGN1412, or OKT3, an anti-CD3 mAb, can cause severe adverse events…”
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Efficacy and safety of trimodulin in patients with severe COVID-19: results from a randomised, placebo-controlled, double-blind, multicentre, phase II trial (ESsCOVID) by Agafina, Alina, Aguiar, Valeria Cristina, Rossovskaya, Maria, Fartoukh, Muriel Sarah, Hajjar, Ludhmila Abrahao, Thiéry, Guillaume, Timsit, Jean-François, Gordeev, Ivan, Protsenko, Denis, Carbone, Javier, Pellegrini, Rita, Stadnik, Claudio Marcel Berdun, Avdeev, Sergey, Ferrer, Miquel, Heinz, Corina C, Häder, Thomas, Langohr, Patrick, Bobenhausen, Iris, Schüttrumpf, Jörg, Staus, Alexander, Ruehle, Markus, Weissmüller, Sabrina, Wartenburg-Demand, Andrea, Torres, Antoni

“…Trimodulin (human polyvalent immunoglobulin [Ig] M ~ 23%, IgA ~ 21%, IgG ~ 56% preparation) has previously been associated with a lower mortality rate in a…”
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The Functional Role of IgA in the IgM/IgA-Enriched Immunoglobulin Preparation Trimodulin by Bohländer, Fabian, Weißmüller, Sabrina, Riehl, Dennis, Gutscher, Marcus, Schüttrumpf, Jörg, Faust, Stefanie

“…In comparison to human immunoglobulin (Ig) G, antibodies of IgA class are not well investigated. In line with this, the functional role of the IgA component in…”
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The Dual Role of a Polyvalent IgM/IgA-Enriched Immunoglobulin Preparation in Activating and Inhibiting the Complement System by Schmidt, Carolin, Weißmüller, Sabrina, Bohländer, Fabian, Germer, Matthias, König, Martin, Staus, Alexander, Wartenberg-Demand, Andrea, Heinz, Corina C., Schüttrumpf, Jörg

“…Activation of the complement system is important for efficient clearance of a wide variety of pathogens via opsonophagocytosis, or by direct lysis via…”
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Exhaustive Proteome Mining for Functional MHC‑I Ligands by Koch, Christian P, Perna, Anna M, Weissmüller, Sabrina, Bauer, Stefanie, Pillong, Max, Baleeiro, Renato B, Reutlinger, Michael, Folkers, Gerd, Walden, Peter, Wrede, Paul, Hiss, Jan A, Waibler, Zoe, Schneider, Gisbert

“…We present the development and application of a new machine-learning approach to exhaustively and reliably identify major histocompatibility complex class I…”
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Human Fcγ receptors compete for TGN1412 binding that determines the antibody's effector function by Dudek, Simone, Weißmüller, Sabrina, Anzaghe, Martina, Miller, Lilija, Sterr, Sarah, Hoffmann, Katja, Hengel, Hartmut, Waibler, Zoe

“…The first‐in‐human clinical trial of the CD28‐specific monoclonal antibody (mAb) TGN1412 resulted in a life‐threatening cytokine release syndrome. Although…”
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Danger signal-dependent activation of human dendritic cells by plasma-derived factor VIII products by Miller, L, Weissmüller, S, Ringler, E, Crauwels, P, van Zandbergen, G, Seitz, R, Waibler, Z

“…Treatment of haemophilia A by infusions of the clotting factor VIII (FVIII) results in the development of inhibitors/anti-drug antibodies in up to 25 % of…”
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Pneumolysin induces platelet destruction, not platelet activation, which can be prevented by immunoglobulin preparations in vitro by Jahn, Kristin, Handtke, Stefan, Palankar, Raghavendra, Weißmüller, Sabrina, Nouailles, Geraldine, Kohler, Thomas P., Wesche, Jan, Rohde, Manfred, Heinz, Corina, Aschenbrenner, Axel F., Wolff, Martina, Schüttrumpf, Jörg, Witzenrath, Martin, Hammerschmidt, Sven, Greinacher, Andreas

“…Community-acquired pneumonia by primary or superinfections with Streptococcus pneumoniae can lead to acute respiratory distress requiring mechanical…”
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ICOS-LICOS interaction is critically involved in TGN1412-mediated T-cell activation by Weissmüller, Sabrina, Semmler, Linda Y., Kalinke, Ulrich, Christians, Stefan, Müller-Berghaus, Jan, Waibler, Zoe

“…TGN1412, a superagonistic CD28-specific antibody, was shown to require Fc-cross-linking or immobilization as a prerequisite to mediate T-cell proliferation and…”
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Satisficing or maximizing in public-private partnerships? A laboratory experiment on strategic bargaining by Weißmüller, Kristina S., Bouwman, Robin, Vogel, Rick

“…Cross-sectoral strategic negotiation is a key challenge in PPPs. Based on framing and game theory, we investigate the effect of sectoral agency, affect, and…”
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Conceptual foundations of workforce homogeneity in the public sector. Insights from a systematic review on causes, consequences, and blind spots by Seidemann, Iris, Weißmüller, Kristina S.

“…Workforce diversity is a key objective of public personnel policies worldwide. We augment this discourse by exploring the complementary and multifaceted…”
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Publicness and micro-level risk behaviour: experimental evidence on stereotypical discounting behaviour by Weißmüller, Kristina S.

“…Anti-public stereotypes suggest that public agents are more likely to shun risk and tolerate delay vis-à-vis private agents. Based on context dependency of…”
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Private Life Events as Antecedents for Public Employees’ Engagement and Burnout by Weißmüller, Kristina S., Ritz, Adrian, Steijn, A. J. (Bram), Alfes, Kerstin

“…While it is known that life events are predictive for psychological and physiological illnesses, empirical research on the relationship between private life…”
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