Search Results - "Weiß, René"
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Different Potential of Extracellular Vesicles to Support Thrombin Generation: Contributions of Phosphatidylserine, Tissue Factor, and Cellular Origin
Published in Scientific reports (26-07-2017)“…Cells release diverse types of vesicles constitutively or in response to proliferation, injury, inflammation, or stress. Extracellular vesicles (EVs) are…”
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Hypoxia Conditioned Mesenchymal Stem Cell-Derived Extracellular Vesicles Induce Increased Vascular Tube Formation in vitro
Published in Frontiers in bioengineering and biotechnology (23-10-2019)“…Mesenchymal stem/stromal cells (MSCs) display a variety of therapeutically relevant effects, such as the induction of angiogenesis, particularly under hypoxic…”
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Characterization of extracellular vesicles in whole blood: Influence of pre-analytical parameters and visualization of vesicle-cell interactions using imaging flow cytometry
Published in Biochemical and biophysical research communications (09-09-2016)“…Extracellular vesicles are central players in intercellular communication and are released from the plasma membrane under tightly regulated conditions,…”
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4
Dynamic cultivation of human mesenchymal stem/stromal cells for the production of extracellular vesicles in a 3D bioreactor system
Published in Biotechnology letters (01-04-2024)“…Purpose 3D cell culture and hypoxia have been demonstrated to increase the therapeutic effects of mesenchymal stem/stromal cells (MSCs)-derived extracellular…”
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Extracellular vesicles are associated with C-reactive protein in sepsis
Published in Scientific reports (26-03-2021)“…There is increasing evidence that C-reactive protein (CRP) can mediate inflammatory reactions following the transformation of functionally inert pentameric CRP…”
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Heparin-Functionalized Adsorbents Eliminate Central Effectors of Immunothrombosis, including Platelet Factor 4, High-Mobility Group Box 1 Protein and Histones
Published in International journal of molecular sciences (05-02-2022)“…Inflammation and thrombosis are closely intertwined in numerous disorders, including ischemic events and sepsis, as well as coronavirus disease 2019…”
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The fluorochrome-to-protein ratio is crucial for the flow cytometric detection of tissue factor on extracellular vesicles
Published in Scientific reports (17-03-2024)“…Extracellular vesicles (EVs) have crucial roles in hemostasis and coagulation. They sustain coagulation by exposing phosphatidylserine and initiate clotting by…”
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Comparative Analysis of Platelet-Derived Extracellular Vesicles Using Flow Cytometry and Nanoparticle Tracking Analysis
Published in International journal of molecular sciences (07-04-2021)“…Growing interest in extracellular vesicles (EVs) has prompted the advancements of protocols for improved EV characterization. As a high-throughput,…”
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9
Storage of human whole blood, but not isolated monocytes, preserves the distribution of monocyte subsets
Published in Biochemical and biophysical research communications (01-10-2019)“…Human monocytes include CD14++CD16− (classical), CD14++CD16+ (intermediate), and CD14+CD16++ (non-classical) subsets with divergent roles in immune regulation…”
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10
Tetracene Dimers: A Platform for Intramolecular Down- and Up-conversion
Published in Journal of the American Chemical Society (23-08-2023)“…Photon energy conversion can be accomplished in many different ways, including the two opposing manners, down-conversion (i.e., singlet fission, SF) and…”
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Expression of Tissue Factor and Platelet/Leukocyte Markers on Extracellular Vesicles Reflect Platelet-Leukocyte Interaction in Severe COVID-19
Published in International journal of molecular sciences (01-12-2023)“…Severe COVID-19 is frequently associated with thromboembolic complications. Increased platelet activation and platelet-leukocyte aggregate formation can…”
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Differential Interaction of Platelet-Derived Extracellular Vesicles with Leukocyte Subsets in Human Whole Blood
Published in Scientific reports (26-04-2018)“…Secretion and exchange of biomolecules via extracellular vesicles (EVs) are crucial mechanisms in intercellular communication, and the roles of EVs in…”
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13
Tuning Interactions to Control Molecular Down Conversion in [2.2]Paracyclophane Bridged Oligo‐Tetracenes
Published in Advanced functional materials (01-11-2024)“…In tetracene, the energies of the lowest singlet excited state and twice that of the lowest triplet excited state are similar, allowing both down‐conversion…”
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14
Activated Platelets and Platelet-Derived Extracellular Vesicles Mediate COVID-19-Associated Immunothrombosis
Published in Frontiers in cell and developmental biology (06-07-2022)“…Activated platelets and platelet-derived extracellular vesicles (EVs) have emerged as central players in thromboembolic complications associated with severe…”
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15
Polyzwitterionic Coating of Porous Adsorbents for Therapeutic Apheresis
Published in Journal of functional biomaterials (03-11-2022)“…Adsorbents for whole blood apheresis need to be highly blood compatible to minimize the activation of blood cells on the biomaterial surface. Here, we…”
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Differential Interaction of Platelet-Derived Extracellular Vesicles With Circulating Immune Cells: Roles of TAM Receptors, CD11b, and Phosphatidylserine
Published in Frontiers in immunology (11-12-2018)“…Secretion and exchange of biomolecules by extracellular vesicles (EVs) are crucial in intercellular communication and enable cells to adapt to alterations in…”
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Extracellular Vesicles Derived From Platelets, Red Blood Cells, and Monocyte-Like Cells Differ Regarding Their Ability to Induce Factor XII-Dependent Thrombin Generation
Published in Frontiers in cell and developmental biology (05-05-2020)“…As transmitters of biological information, extracellular vesicles (EVs) are crucial for the maintenance of physiological homeostasis, but also contribute to…”
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Thrombocyte Adhesion and Release of Extracellular Microvesicles Correlate with Surface Morphology of Adsorbent Polymers for Lipid Apheresis
Published in Biomacromolecules (14-07-2014)“…Whole blood lipid apheresis is clinically applied to reduce low density lipoprotein cholesterol in patients with homozygous familial hypercholesterolemia…”
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Desialylation of platelet surface glycans enhances platelet adhesion to adsorbent polymers for lipoprotein apheresis
Published in International journal of artificial organs (01-06-2021)“…Background: Lipoprotein apheresis is an important therapeutic option in homozygous familial hypercholesterolemia, progressive atherosclerosis, or when…”
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Analysis of Inflammatory Mediator Profiles in Sepsis Patients Reveals That Extracellular Histones Are Strongly Elevated in Nonsurvivors
Published in Mediators of inflammation (2021)“…The timely recognition of sepsis and the prediction of its clinical course are challenging due to the complex molecular mechanisms leading to organ failure and…”
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