Search Results - "Wei, Yaxun"
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The m6A Reader IGF2BP2 Regulates Macrophage Phenotypic Activation and Inflammatory Diseases by Stabilizing TSC1 and PPARγ
Published in Advanced science (01-07-2021)“…Phenotypic polarization of macrophages is regulated by a milieu of cues in the local tissue microenvironment. Currently, little is known about how the…”
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PAIP1 binds to pre-mRNA and regulates alternative splicing of cancer pathway genes including VEGFA
Published in BMC genomics (03-10-2024)“…Poly (A) binding protein interacting protein 1 (PAIP1) has been shown to causally contribute to the development and progression of cancer. However, the…”
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Poly(A)-seq: A method for direct sequencing and analysis of the transcriptomic poly(A)-tails
Published in PloS one (16-06-2020)“…Poly(A) tails at the 3’ end of eukaryotic messenger RNAs control mRNA stability and translation efficiency. Facilitated by various NGS methods, alternative…”
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Iron metabolism protein transferrin receptor 1 involves in cervical cancer progression by affecting gene expression and alternative splicing in HeLa cells
Published in Genes & genomics (01-06-2022)“…Background Transferrin receptor 1 (TfR1), encoded by TFRC , is a key regulator of iron homeostasis and plays important roles in many diseases, including…”
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HMGB1 prefers to interact with structural RNAs and regulates rRNA methylation modification and translation in HeLa cells
Published in BMC genomics (05-04-2024)“…High-mobility group B1 (HMGB1) is both a DNA binding nuclear factor modulating transcription and a crucial cytokine that mediates the response to both…”
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CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell
Published in BMC cancer (27-05-2019)“…Aberrant spliced isoforms are specifically associated with cancer progression and metastasis. The cytoplasmic adaptor CRKL (v-crk avian sarcoma virus CT10…”
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Transcriptome profiling reveals transcriptional and alternative splicing regulation in the early embryonic development of hair follicles in the cashmere goat
Published in Scientific reports (28-11-2019)“…The undercoat fiber of the cashmere goat, from the secondary hair follicle (HF), possesses commercial value. However, very few studies have focused on the…”
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ATP5A1 Participates in Transcriptional and Posttranscriptional Regulation of Cancer-Associated Genes by Modulating Their Expression and Alternative Splicing Profiles in HeLa Cells
Published in Technology in cancer research & treatment (01-01-2021)“…Background: Aberrant expression and alternative splicing of oncogenes are the driving events in tumor initiation and development. But how these events are…”
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Transcriptome analysis of sheep oral mucosa response to Orf virus infection
Published in PloS one (26-10-2017)“…Contagious ecthyma is a highly contagious disease with worldwide distribution, which is caused by the Orf virus (ORFV) belonging to the Parapoxvirus. To study…”
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Tristetraprolin specifically regulates the expression and alternative splicing of immune response genes in HeLa cells
Published in BMC immunology (02-05-2019)“…Tristetraprolin (TTP) is an RNA binding protein that plays a critical role in regulating proinflammatory immune responses by destabilizing target mRNAs via…”
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Attenuated Duck Hepatitis A Virus Infection Is Associated With High mRNA Maintenance in Duckling Liver via m6A Modification
Published in Frontiers in immunology (09-06-2022)“…Host translation is generally modulated by viral infection, including duck hepatitis A virus (DHAV) infection. Previously, we reported that cellular protein…”
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Transcriptome analysis reveals the potential biological function of FSCN1 in HeLa cervical cancer cells
Published in PeerJ (San Francisco, CA) (02-02-2022)“…Fascin actin-bundling protein 1 (FSCN1), an actin-bundling protein associated with cell migration and invasion, is highly expressed in various tumor tissues…”
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An integrated analysis of lncRNA and mRNA expression profiles in the kidneys of mice with lupus nephritis
Published in PeerJ (San Francisco, CA) (16-02-2021)“…Long noncoding RNAs (lncRNAs) are persistently expressed and have been described as potential biomarkers and therapeutic targets in various diseases. However,…”
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hnRNPDL extensively regulates transcription and alternative splicing
Published in Gene (01-03-2019)“…RNA binding proteins (RBPs) are key players of genome regulation. Here we report the transcriptome study of HnRNP D-Like protein, which belongs to the hnRNP…”
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TCTP participates in hepatic metabolism by regulating gene expression involved in insulin resistance
Published in Gene (05-02-2021)“…•TCTP regulates transcriptome at both the transcriptional and alternative splicing levels in HepG2 cells.•TCTP targets the expression of gens in cellular…”
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Tristetraprolin-RNA interaction map reveals a novel TTP-RelB regulatory network for innate immunity gene expression
Published in Molecular immunology (01-05-2020)“…•iRIP-seq captures the RNA targets directly and indirectly bound by TTP.•Over-representation of AUUUA motif occurs not only in the 3’UTR but also in the…”
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Comparative study on seasonal hair follicle cycling by analysis of the transcriptomes from cashmere and milk goats
Published in Genomics (San Diego, Calif.) (01-01-2020)“…Guard hair and cashmere undercoat are developed from primary and secondary hair follicle, respectively. Little is known about the gene expression differences…”
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Poly-tails
Published in PloS one (16-06-2020)“…Poly(A) tails at the 3' end of eukaryotic messenger RNAs control mRNA stability and translation efficiency. Facilitated by various NGS methods, alternative…”
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Poly
Published in PloS one (16-06-2020)“…Poly(A) tails at the 3' end of eukaryotic messenger RNAs control mRNA stability and translation efficiency. Facilitated by various NGS methods, alternative…”
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