Search Results - "Wei, Yaohua"

Selective transferrin coating as a facile strategy to fabricate BBB-permeable and targeted vesicles for potent RNAi therapy of brain metastatic breast cancer in vivo by Wei, Yaohua, Sun, Yinping, Wei, Jingjing, Qiu, Xinyun, Meng, Fenghua, Storm, Gert, Zhong, Zhiyuan

“…Brain metastases are a most disturbing situation for breast cancer patients as there is basically no adequate treatment available. Any potential drug…”
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Apolipoprotein E Peptide-Guided Disulfide-Cross-Linked Micelles for Targeted Delivery of Sorafenib to Hepatocellular Carcinoma by Li, Yingwen, Wei, Jingjing, Wei, Yaohua, Cheng, Liang, Guo, Beibei, Meng, Fenghua, Li, Feng, Zhong, Zhiyuan

“…Sorafenib (SF) is an FDA-approved molecular-targeted drug for treating hepatocellular carcinoma (HCC). SF, however, suffers from poor water solubility, low…”
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The challenge and opportunity of gut microbiota‐targeted nanomedicine for colorectal cancer therapy by Wei, Yaohua, Shen, Feng, Song, Huidong, Zhao, Ruifang, Feng, Weiyue, Pan, Yue, Li, Xiaobo, Yu, Huanling, Familiari, Giuseppe, Relucenti, Michela, Aschner, Michael, Shi, Hanping, Chen, Rui, Nie, Guangjun, Chen, Hanqing

“…The gut microbiota is an integral component of the colorectal cancer (CRC) microenvironment and is intimately associated with CRC initiation, progression, and…”
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Transferrin-binding peptide functionalized polymersomes mediate targeted doxorubicin delivery to colorectal cancer in vivo by Wei, Yaohua, Gu, Xiaolei, Sun, Yinping, Meng, Fenghua, Storm, Gert, Zhong, Zhiyuan

“…Transferrin receptor (TfR) is a promising target validated in the clinical trials for managing various malignancies. Transferrin (Tf) and single chain antibody…”
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cRGD-decorated biodegradable polytyrosine nanoparticles for robust encapsulation and targeted delivery of doxorubicin to colorectal cancer in vivo by Gu, Xiaolei, Wei, Yaohua, Fan, Qianyi, Sun, Huanli, Cheng, Ru, Zhong, Zhiyuan, Deng, Chao

“…The clinical success of nanomedicines demands on the development of simple biodegradable nanocarriers that can efficiently and stably encapsulate…”
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Stimuli-Responsive Polymersomes: Reshaping the Immunosuppressive Tumor Microenvironment by Wei, Yaohua, Weng, Xiao, Wang, Yayun, Yang, Weijing

“…The progression of cancer involves mutations in normal cells, leading to uncontrolled division and tissue destruction, highlighting the complexity of tumor…”
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Granzyme B-loaded, cell-selective penetrating and reduction-responsive polymersomes effectively inhibit progression of orthotopic human lung tumor in vivo by Yang, Weijing, Wei, Yaohua, Yang, Liang, Zhang, Jian, Zhong, Zhiyuan, Storm, Gert, Meng, Fenghua

“…The clinical use of protein therapeutics with intracellular targets is hampered by its in vivo fragility and low cell permeability. Here, we report that…”
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Nanopolymersomes with an Ultrahigh Iodine Content for High‐Performance X‐Ray Computed Tomography Imaging In Vivo by Zou, Yan, Wei, Yaohua, Wang, Guanglin, Meng, Fenghua, Gao, Mingyuan, Storm, Gert, Zhong, Zhiyuan

“…Biocompatible and biodegradable nanopolymersomes with an unprecedented iodine content, low viscosity, and iso‐osmolality achieve significantly enhanced CT…”
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Low-toxicity transferrin-guided polymersomal doxorubicin for potent chemotherapy of orthotopic hepatocellular carcinoma in vivo by Wei, Yaohua, Gu, Xiaolei, Cheng, Liang, Meng, Fenghua, Storm, Gert, Zhong, Zhiyuan

“…[Display omitted] Hepatocellular carcinoma (HCC) remains one of the most lethal malignancies. The current chemotherapy with typically low tumor uptake and high…”
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Iodine-Rich Polymersomes Enable Versatile SPECT/CT Imaging and Potent Radioisotope Therapy for Tumor in Vivo by Cao, Jinsong, Wei, Yaohua, Zhang, Yanxiang, Wang, Guanglin, Ji, Xiang, Zhong, Zhiyuan

“…Emerging tumor treatment demands high sensitivity and high-spatial resolution diagnosis in combination with targeted therapy. Here, we report that iodine-rich…”
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Cetuximab–Polymersome–Mertansine Nanodrug for Potent and Targeted Therapy of EGFR-Positive Cancers by Yue, Shujing, Zhang, Yifan, Wei, Yaohua, Haag, Rainer, Sun, Huanli, Zhong, Zhiyuan

“…Targeted nanomedicines particularly armed with monoclonal antibodies are considered to be the most promising advanced chemotherapy for malignant cancers;…”
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Small-Sized and Robust Chimaeric Lipopepsomes: A Simple and Functional Platform with High Protein Loading for Targeted Intracellular Delivery of Protein Toxin in Vivo by Qiu, Min, Zhang, Zhenqi, Wei, Yaohua, Sun, Huanli, Meng, Fenghua, Deng, Chao, Zhong, Zhiyuan

“…How to chaperone protein drugs into target tumor cells in vivo is a big challenge. Here, we report on small-sized and robust chimaeric vesicles (lipopepsomes)…”
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Correction to “Cetuximab–Polymersome–Mertansine Nanodrug for Potent and Targeted Therapy of EGFR-Positive Cancers” by Yue, Shujing, Zhang, Yifan, Wei, Yaohua, Haag, Rainer, Sun, Huanli, Zhong, Zhiyuan

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Nanoagents Based on Poly(ethylene glycol)‐b‐Poly(l‐thyroxine) Block Copolypeptide for Enhanced Dual‐Modality Imaging and Targeted Tumor Radiotherapy by Gu, Xiaolei, Zhu, Zhehong, Fan, Qianyi, Wei, Yaohua, Wang, Guanglin, Meng, Fenghua, Zhong, Zhiyuan, Deng, Chao

“…Future healthcare requires development of novel theranostic agents that are capable of not only enhancing diagnosis and monitoring therapeutic responses but…”
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Selective Cell Penetrating Peptide‐Functionalized Envelope‐Type Chimeric Lipopepsomes Boost Systemic RNAi Therapy for Lung Tumors by Qiu, Min, Ouyang, Jia, Wei, Yaohua, Zhang, Jian, Lan, Qing, Deng, Chao, Zhong, Zhiyuan

“…Small interfering RNA (siRNA) is considered a highly specific and potent biotherapeutic that holds tremendous potential for the treatment of various diseases…”
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Correction to “α3β1 Integrin-Targeting Polymersomal Docetaxel as an Advanced Nanotherapeutic for Nonsmall Cell Lung Cancer Treatment” by Zou, Yan, Sun, Yinping, Guo, Beibei, Wei, Yaohua, Xia, Yifeng, Huangfu, Zhenyuan, Meng, Fenghua, van Hest, Jan C. M., Yuan, Jiandong, Zhong, Zhiyuan

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Delivery of neutrophil membrane encapsulated non-steroidal anti-inflammatory drugs by degradable biopolymer microneedle patch for rheumatoid arthritis therapy by Lin, Yixuan, Chen, Yang, Deng, Ronghui, Qin, Hao, Li, Nan, Qin, Yuting, Chen, Hanqing, Wei, Yaohua, Wang, Zeming, Sun, Qing, Qiu, Wenyi, Shi, Jian, Chen, Long, Wang, Yuguang, Nie, Guangjun, Zhao, Ruifang

“…Rheumatoid arthritis (RA) is a common chronic autoimmune disease and eventually ends in severe disability and death. RA has no cure, but there are some…”
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Correction to "α 3 β 1 Integrin-Targeting Polymersomal Docetaxel as an Advanced Nanotherapeutic for Nonsmall Cell Lung Cancer Treatment" by Zou, Yan, Sun, Yinping, Guo, Beibei, Wei, Yaohua, Xia, Yifeng, Huangfu, Zhenyuan, Meng, Fenghua, van Hest, Jan C M, Yuan, Jiandong, Zhong, Zhiyuan

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GE11 peptide-installed chimaeric polymersomes tailor-made for high-efficiency EGFR-targeted protein therapy of orthotopic hepatocellular carcinoma by Zhou, Cheng, Xia, Yifeng, Wei, Yaohua, Cheng, Liang, Wei, Jingjing, Guo, Beibei, Meng, Fenghua, Cao, Shoupeng, van Hest, Jan C.M., Zhong, Zhiyuan

“…Hepatocellular carcinoma (HCC) remains a leading malignancy with a high mortality and little improvement in treatments. Protein drugs though known for their…”
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Construction of a Degradation-Free DNA Conjugated Nanoprobe and Its Application in Rapid Field Screening for Sulfur Mustard by Sun, Jiefang, Li, Chunzheng, Shan, Wenchong, Wei, Yaohua, Liu, Rui, Li, Hui, Cao, Dong, Guo, Qiaozhen, Zhao, Huachao, Liu, Runqing, Shao, Bing

“…Sulfur mustard (SM) is a notorious blistering chemical warfare agent. Rapid field screening for trace SM is of vital significance for the detection of…”
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