Search Results - "Wei, Xiawei"

The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis by Huang, Yuhe, Hong, Weiqi, Wei, Xiawei

“…Abstract Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic development and tissue regeneration. However, aberrant…”
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AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications by Zhu, Chenjing, Wei, Yuquan, Wei, Xiawei

“…Molecular targeted therapy for cancer has been a research hotspot for decades. AXL is a member of the TAM family with the high-affinity ligand growth…”
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Targeting TGF-β signal transduction for fibrosis and cancer therapy by Peng, Dandan, Fu, Minyang, Wang, Manni, Wei, Yuquan, Wei, Xiawei

“…Transforming growth factor β (TGF-β) has long been identified with its intensive involvement in early embryonic development and organogenesis, immune…”
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Role of the CCL2‐CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting by Xu, Maosen, Wang, Yang, Xia, Ruolan, Wei, Yuquan, Wei, Xiawei

“…The chemokine ligand CCL2 and its receptor CCR2 are implicated in the initiation and progression of various cancers. CCL2 can activate tumour cell growth and…”
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Mesenchymal stem/stromal cells in cancer therapy by Lan, Tianxia, Luo, Min, Wei, Xiawei

“…The multipotent mesenchymal stem/stromal cells (MSCs), initially discovered from bone marrow in 1976, have been identified in nearly all tissues of human body…”
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Epigenetic regulation of macrophages: from homeostasis maintenance to host defense by Chen, Siyuan, Yang, Jing, Wei, Yuquan, Wei, Xiawei

“…Macrophages are crucial members of the innate immune response and important regulators. The differentiation and activation of macrophages require the timely…”
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Targeting PI3K in cancer: mechanisms and advances in clinical trials by Yang, Jing, Nie, Ji, Ma, Xuelei, Wei, Yuquan, Peng, Yong, Wei, Xiawei

“…Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling is one of the most important intracellular pathways, which can be…”
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SARS‐CoV‐2 Omicron variant: Characteristics and prevention by He, Xuemei, Hong, Weiqi, Pan, Xiangyu, Lu, Guangwen, Wei, Xiawei

“…Coronavirus disease 2019 (COVID‐19) has brought about a great threat to global public health. Recently, a new severe acute respiratory syndrome coronavirus 2…”
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Cellular Toxicity and Immunological Effects of Carbon-based Nanomaterials by Yuan, Xia, Zhang, Xiangxian, Sun, Lu, Wei, Yuquan, Wei, Xiawei

“…Carbon nanomaterials are a growing family of materials featuring unique physicochemical properties, and their widespread application is accompanied by…”
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Targeting the tumor stroma for cancer therapy by Xu, Maosen, Zhang, Tao, Xia, Ruolan, Wei, Yuquan, Wei, Xiawei

“…Tumors are comprised of both cancer cells and surrounding stromal components. As an essential part of the tumor microenvironment, the tumor stroma is highly…”
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Inhibition of FGF‐FGFR and VEGF‐VEGFR signalling in cancer treatment by Liu, Guihong, Chen, Tao, Ding, Zhenyu, Wang, Yang, Wei, Yuquan, Wei, Xiawei

“…The sites of targeted therapy are limited and need to be expanded. The FGF‐FGFR signalling plays pivotal roles in the oncogenic process, and FGF/FGFR…”
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Cancer vaccines as promising immuno-therapeutics: platforms and current progress by Liu, Jian, Fu, Minyang, Wang, Manni, Wan, Dandan, Wei, Yuquan, Wei, Xiawei

“…Research on tumor immunotherapy has made tremendous progress in the past decades, with numerous studies entering the clinical evaluation. The cancer vaccine is…”
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mRNA vaccine: a potential therapeutic strategy by Wang, Yang, Zhang, Ziqi, Luo, Jingwen, Han, Xuejiao, Wei, Yuquan, Wei, Xiawei

“…mRNA vaccines have tremendous potential to fight against cancer and viral diseases due to superiorities in safety, efficacy and industrial production. In…”
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CCL5/CCR5 axis in human diseases and related treatments by Zeng, Zhen, Lan, Tianxia, Wei, Yuquan, Wei, Xiawei

“…To defense harmful stimuli or maintain the immune homeostasis, the body produces and recruits a superfamily of cytokines such as interleukins, interferons,…”
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cGAS‐STING pathway agonists are promising vaccine adjuvants by Tian, Xinyu, Ai, Jiayuan, Tian, Xiaohe, Wei, Xiawei

“…Adjuvants are of critical value in vaccine development as they act on enhancing immunogenicity of antigen and inducing long‐lasting immunity. However, there…”
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CXCL13-CXCR5 axis: Regulation in inflammatory diseases and cancer by Wang, Binhan, Wang, Manni, Ao, Danyi, Wei, Xiawei

“…Chemokine C-X-C motif ligand 13 (CXCL13), originally identified as a B-cell chemokine, plays an important role in the immune system. The interaction between…”
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cGAS-STING pathway in cancer biotherapy by Wang, Yang, Luo, Jingwen, Alu, Aqu, Han, Xuejiao, Wei, Yuquan, Wei, Xiawei

“…Abstract The activation of the cGAS-STING pathway has tremendous potential to improve anti-tumor immunity by generating type I interferons. In recent decades,…”
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Inflammatory Cytokines in Cancer: Comprehensive Understanding and Clinical Progress in Gene Therapy by Lan, Tianxia, Chen, Li, Wei, Xiawei

“…The relationship between chronic inflammation and neoplastic diseases is not fully understood. The inflammatory microenvironment of a tumor is an intricate…”
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Mitochondrial DNA in the regulation of innate immune responses by Fang, Chunju, Wei, Xiawei, Wei, Yuquan

“…Mitochondrion is known as the energy factory of the cell, which is also a unique mammalian organelle and con. sidered to be evolved from aerobic prokaryotes…”
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Role of lysosomes in physiological activities, diseases, and therapy by Zhang, Ziqi, Yue, Pengfei, Lu, Tianqi, Wang, Yang, Wei, Yuquan, Wei, Xiawei

“…Long known as digestive organelles, lysosomes have now emerged as multifaceted centers responsible for degradation, nutrient sensing, and immunity. Growing…”
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