Search Results - "Wei, Ronnie R"

The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment by Harrison, Stephen C, Wei, Ronnie R, Al-Bassam, Jawdat

“…Kinetochores are multicomponent assemblies that connect chromosomal centromeres to mitotic-spindle microtubules. The Ndc80 complex is an essential core element…”
Get full text

The Ndc80 Kinetochore Complex Forms Load-Bearing Attachments to Dynamic Microtubule Tips via Biased Diffusion by Powers, Andrew F., Franck, Andrew D., Gestaut, Daniel R., Cooper, Jeremy, Gracyzk, Beth, Wei, Ronnie R., Wordeman, Linda, Davis, Trisha N., Asbury, Charles L.

“…Kinetochores couple chromosomes to the assembling and disassembling tips of microtubules, a dynamic behavior that is fundamental to mitosis in all eukaryotes…”
Get full text

Human acid sphingomyelinase structures provide insight to molecular basis of Niemann–Pick disease by Zhou, Yan-Feng, Metcalf, Matthew C., Garman, Scott C., Edmunds, Tim, Qiu, Huawei, Wei, Ronnie R.

“…Acid sphingomyelinase (ASM) hydrolyzes sphingomyelin to ceramide and phosphocholine, essential components of myelin in neurons. Genetic alterations in ASM lead…”
Get full text

Molecular Organization of the Ndc80 Complex, an Essential Kinetochore Component by Wei, Ronnie R., Sorger, Peter K., Harrison, Stephen C.

“…The four-protein Ndc80 complex, an essential kinetochore component conserved from yeast to humans, plays an indispensable role in proper chromosome alignment…”
Get full text

Structural Analysis of Bub3 Interactions in the Mitotic Spindle Checkpoint by Larsen, Nicholas A., Al-Bassam, Jawdat, Wei, Ronnie R., Harrison, Stephen C.

“…The Mad3/BubR1, Mad2, Bub1, and Bub3 proteins are gatekeepers for the transition from metaphase to anaphase. Mad3 from Saccharomyces cerevisiae has homology to…”
Get full text

Implications of Promiscuous Pim-1 Kinase Fragment Inhibitor Hydrophobic Interactions for Fragment-Based Drug Design by Good, Andrew C, Liu, Jinyu, Hirth, Bradford, Asmussen, Gary, Xiang, Yibin, Biemann, Hans-Peter, Bishop, Kimberly A, Fremgen, Trisha, Fitzgerald, Maria, Gladysheva, Tatiana, Jain, Annuradha, Jancsics, Katherine, Metz, Markus, Papoulis, Andrew, Skerlj, Renato, Stepp, J. David, Wei, Ronnie R

“…We have studied the subtleties of fragment docking and binding using data generated in a Pim-1 kinase inhibitor program. Crystallographic and docking data…”
Get full text

Structure of a Central Component of the Yeast Kinetochore: The Spc24p/Spc25p Globular Domain by Wei, Ronnie R., Schnell, Jason R., Larsen, Nicholas A., Sorger, Peter K., Chou, James J., Harrison, Stephen C.

“…The Ndc80 complex, a kinetochore component conserved from yeast to humans, is essential for proper chromosome alignment and segregation during mitosis. It is…”
Get full text

Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques by Xu, Ling, Pegu, Amarendra, Rao, Ercole, Doria-Rose, Nicole, Beninga, Jochen, McKee, Krisha, Lord, Dana M., Wei, Ronnie R., Deng, Gejing, Louder, Mark, Schmidt, Stephen D., Mankoff, Zachary, Wu, Lan, Asokan, Mangaiarkarasi, Beil, Christian, Lange, Christian, Leuschner, Wulf Dirk, Kruip, Jochen, Sendak, Rebecca, Kwon, Young Do, Zhou, Tongqing, Chen, Xuejun, Bailer, Robert T., Wang, Keyun, Choe, Misook, Tartaglia, Lawrence J., Barouch, Dan H., O’Dell, Sijy, Todd, John-Paul, Burton, Dennis R., Roederer, Mario, Connors, Mark, Koup, Richard A., Kwong, Peter D., Yang, Zhi-yong, Mascola, John R., Nabel, Gary J.

“…The development of an effective AIDS vaccine has been challenging because of viral genetic diversity and the difficulty of generating broadly neutralizing…”
Get full text

Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation by Wu, Lan, Seung, Edward, Xu, Ling, Rao, Ercole, Lord, Dana M, Wei, Ronnie R, Cortez-Retamozo, Virna, Ospina, Beatriz, Posternak, Valeriya, Ulinski, Gregory, Piepenhagen, Peter, Francesconi, Elisa, El-Murr, Nizar, Beil, Christian, Kirby, Patrick, Li, Aiqun, Fretland, Jennifer, Vicente, Rita, Deng, Gejing, Dabdoubi, Tarik, Cameron, Beatrice, Bertrand, Thomas, Ferrari, Paul, Pouzieux, Stéphanie, Lemoine, Cendrine, Prades, Catherine, Park, Anna, Qiu, Huawei, Song, Zhili, Zhang, Bailin, Sun, Fangxian, Chiron, Marielle, Rao, Srinivas, Radošević, Katarina, Yang, Zhi-Yong, Nabel, Gary J

“…Despite the significant therapeutic advances provided by immune-checkpoint blockade and chimeric antigen receptor T cell treatments, many malignancies remain…”
Get full text

Trispecific antibody targeting HIV-1 and T cells activates and eliminates latently-infected cells in HIV/SHIV infections by Promsote, Wanwisa, Xu, Ling, Hataye, Jason, Fabozzi, Giulia, March, Kylie, Almasri, Cassandra G., DeMouth, Megan E., Lovelace, Sarah E., Talana, Chloe Adrienna, Doria-Rose, Nicole A., McKee, Krisha, Hait, Sabrina Helmold, Casazza, Joseph P., Ambrozak, David, Beninga, Jochen, Rao, Ercole, Furtmann, Norbert, Birkenfeld, Joerg, McCarthy, Elizabeth, Todd, John-Paul, Petrovas, Constantinos, Connors, Mark, Hebert, Andrew T., Beck, Jeremy, Shen, Junqing, Zhang, Bailin, Levit, Mikhail, Wei, Ronnie R., Yang, Zhi-yong, Pegu, Amarendra, Mascola, John R., Nabel, Gary J., Koup, Richard A.

“…Agents that can simultaneously activate latent HIV, increase immune activation and enhance the killing of latently-infected cells represent promising…”
Get full text

A multispecific antibody against SARS-CoV-2 prevents immune escape in vitro and confers prophylactic protection in vivo by Misasi, John, Wei, Ronnie R, Wang, Lingshu, Pegu, Amarendra, Wei, Chih-Jen, Oloniniyi, Olamide K, Zhou, Tongqing, Moliva, Juan I, Zhao, Bingchun, Choe, Misook, Yang, Eun Sung, Zhang, Yi, Boruszczak, Marika, Chen, Man, Leung, Kwanyee, Li, Juan, Yang, Zhi-Yong, Andersen, Hanne, Carlton, Kevin, Godbole, Sucheta, Harris, Darcy R, Henry, Amy R, Ivleva, Vera B, Lei, Q Paula, Liu, Cuiping, Longobardi, Lindsay, Merriam, Jonah S, Nase, Danielle, Olia, Adam S, Pessaint, Laurent, Porto, Maciel, Shi, Wei, Wallace, Shannon M, Wolff, Jeremy J, Douek, Daniel C, Suthar, Mehul S, Gall, Jason G, Koup, Richard A, Kwong, Peter D, Mascola, John R, Nabel, Gary J, Sullivan, Nancy J

“…Despite effective countermeasures, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persists worldwide because of its ability to diversify and…”
Get more information

Potent anti-viral activity of a trispecific HIV neutralizing antibody in SHIV-infected monkeys by Pegu, Amarendra, Xu, Ling, DeMouth, Megan E, Fabozzi, Giulia, March, Kylie, Almasri, Cassandra G, Cully, Michelle D, Wang, Keyun, Yang, Eun Sung, Dias, Joana, Fennessey, Christine M, Hataye, Jason, Wei, Ronnie R, Rao, Ercole, Casazza, Joseph P, Promsote, Wanwisa, Asokan, Mangaiarkarasi, McKee, Krisha, Schmidt, Stephen D, Chen, Xuejun, Liu, Cuiping, Shi, Wei, Geng, Hui, Foulds, Kathryn E, Kao, Shing-Fen, Noe, Amy, Li, Hui, Shaw, George M, Zhou, Tongqing, Petrovas, Constantinos, Todd, John-Paul, Keele, Brandon F, Lifson, Jeffrey D, Doria-Rose, Nicole A, Koup, Richard A, Yang, Zhi-Yong, Nabel, Gary J, Mascola, John R

“…Broadly neutralizing antibodies (bNAbs) represent an alternative to drug therapy for the treatment of HIV-1 infection. Immunotherapy with single bNAbs often…”
Get full text

Impact of cysteine variants on the structure, activity, and stability of recombinant human α‐galactosidase A by Qiu, Huawei, Honey, Denise M., Kingsbury, Jonathan S., Park, Anna, Boudanova, Ekaterina, Wei, Ronnie R., Pan, Clark Q., Edmunds, Tim

“…Recombinant human α‐galactosidase A (rhαGal) is a homodimeric glycoprotein deficient in Fabry disease, a lysosomal storage disorder. In this study, each…”
Get full text

Design of a broadly reactive Lyme disease vaccine by Kamp, Heather D., Swanson, Kurt A., Wei, Ronnie R., Dhal, Pradeep K., Dharanipragada, Ram, Kern, Aurelie, Sharma, Bijaya, Sima, Radek, Hajdusek, Ondrej, Hu, Linden T., Wei, Chih-Jen, Nabel, Gary J.

“…A growing global health concern, Lyme disease has become the most common tick-borne disease in the United States and Europe. Caused by the bacterial spirochete…”
Get full text

X-ray and Biochemical Analysis of N370S Mutant Human Acid β-Glucosidase by Wei, Ronnie R., Hughes, Heather, Boucher, Susan, Bird, Julie J., Guziewicz, Nicholas, Van Patten, Scott M., Qiu, Huawei, Pan, Clark Qun, Edmunds, Tim

“…Gaucher disease is caused by mutations in the enzyme acid β-glucosidase (GCase), the most common of which is the substitution of serine for asparagine at…”
Get full text

Structure-based engineering to restore high affinity binding of an isoform-selective anti-TGFβ1 antibody by Lord, Dana M, Bird, Julie J, Honey, Denise M, Best, Annie, Park, Anna, Wei, Ronnie R, Qiu, Huawei

“…Metelimumab (CAT192) is a human IgG4 monoclonal antibody developed as a TGFβ1-specific antagonist. It was tested in clinical trials for the treatment of…”
Get full text

The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors by Xiang, Yibin, Hirth, Bradford, Asmussen, Gary, Biemann, Hans-Peter, Bishop, Kimberly A., Good, Andrew, Fitzgerald, Maria, Gladysheva, Tatiana, Jain, Annuradha, Jancsics, Katherine, Liu, Jinyu, Metz, Markus, Papoulis, Andrew, Skerlj, Renato, Stepp, J. David, Wei, Ronnie R.

“…Fragment based screening using Surface Plasmon Resonance (SPR) followed by Pim-1 biochemical assay identified hit 10. A X-ray structure of the bound complex of…”
Get full text

Structures of a pan‐specific antagonist antibody complexed to different isoforms of TGFβ reveal structural plasticity of antibody–antigen interactions by Moulin, Aaron, Mathieu, Magali, Lawrence, Catherine, Bigelow, Russell, Levine, Mark, Hamel, Christine, Marquette, Jean‐Piere, Parc, Josiane, Loux, Christophe, Ferrari, Paul, Capdevila, Cecile, Dumas, Jacques, Dumas, Bruno, Rak, Alexey, Bird, Julie, Qiu, Huawei, Pan, Clark Q., Edmunds, Tim, Wei, Ronnie R.

“…Various important biological pathways are modulated by TGFβ isoforms; as such they are potential targets for therapeutic intervention. Fresolimumab, also known…”
Get full text

Identification of an RNA-binding Site in the ATP Binding Domain of Escherichia coli Rho by H2O2/Fe-EDTA Cleavage Protection Studies by Wei, R R, Richardson, J P

“…Transcription factor Rho is a ring-shaped, homohexameric protein that causes transcript termination through actions on nascent RNAs that are coupled to ATP…”
Get full text

Impact of cysteine variants on the structure, activity, and stability of recombinant human [alpha]-galactosidase A by Qiu, Huawei, Honey, Denise M, Kingsbury, Jonathan S, Park, Anna, Boudanova, Ekaterina, Wei, Ronnie R, Pan, Clark Q, Edmunds, Tim

“…Recombinant human [alpha]-galactosidase A (rh[alpha]Gal) is a homodimeric glycoprotein deficient in Fabry disease, a lysosomal storage disorder. In this study,…”
Get full text