Search Results - "Wei, Qingxia"

Macrophages Promote Osteoblastic Differentiation In Vivo: Implications in Fracture Repair and Bone Homeostasis by Vi, Linda, Baht, Gurpreet S, Whetstone, Heather, Ng, Adeline, Wei, Qingxia, Poon, Raymond, Mylvaganam, Sivakami, Grynpas, Marc, Alman, Benjamin A

“…ABSTRACT Macrophages are activated in inflammation and during early phases of repair processes. Interestingly, they are also present in bone during…”
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Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice by Vi, Linda, Baht, Gurpreet S., Soderblom, Erik J., Whetstone, Heather, Wei, Qingxia, Furman, Bridgette, Puviindran, Vijitha, Nadesan, Puviindran, Foster, Matthew, Poon, Raymond, White, James P., Yahara, Yasuhito, Ng, Adeline, Barrientos, Tomasa, Grynpas, Marc, Mosely, M. Arthur, Alman, Benjamin A.

“…The pace of repair declines with age and, while exposure to a young circulation can rejuvenate fracture repair, the cell types and factors responsible for…”
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Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing by Chen, Yan, Whetstone, Heather C, Lin, Alvin C, Nadesan, Puviindran, Wei, Qingxia, Poon, Raymond, Alman, Benjamin A

“…Delayed fracture healing causes substantial disability and usually requires additional surgical treatments. Pharmacologic management to improve fracture repair…”
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Mutant IDH is sufficient to initiate enchondromatosis in mice by Hirata, Makoto, Sasaki, Masato, Cairns, Rob A, Inoue, Satoshi, Puviindran, Vijitha, Li, Wanda Y, Snow, Bryan E, Jones, Lisa D, Wei, Qingxia, Sato, Shingo, Tang, Yuning J, Nadesan, Puviindran, Rockel, Jason, Whetstone, Heather, Poon, Raymond, Weng, Angela, Gross, Stefan, Straley, Kimberly, Gliser, Camelia, Xu, Yingxia, Wunder, Jay, Mak, Tak W, Alman, Benjamin A

“…Significance Current genomic and biochemical analysis revealed mutations in isocitrate dehydrogenase ( IDH ) genes associated with several neoplasms and a…”
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TNFα secreted by glioma associated macrophages promotes endothelial activation and resistance against anti-angiogenic therapy by Wei, Qingxia, Singh, Olivia, Ekinci, Can, Gill, Jaspreet, Li, Mira, Mamatjan, Yasin, Karimi, Shirin, Bunda, Severa, Mansouri, Sheila, Aldape, Kenneth, Zadeh, Gelareh

“…One of the most prominent features of glioblastoma (GBM) is hyper-vascularization. Bone marrow-derived macrophages are actively recruited to the tumor and…”
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Multiplatform molecular profiling uncovers two subgroups of malignant peripheral nerve sheath tumors with distinct therapeutic vulnerabilities by Suppiah, Suganth, Mansouri, Sheila, Mamatjan, Yasin, Liu, Jeffrey C., Bhunia, Minu M., Patil, Vikas, Rath, Prisni, Mehani, Bharati, Heir, Pardeep, Bunda, Severa, Velez-Reyes, German L., Singh, Olivia, Ijad, Nazanin, Pirouzmand, Neda, Dalcourt, Tatyana, Meng, Ying, Karimi, Shirin, Wei, Qingxia, Nassiri, Farshad, Pugh, Trevor J., Bader, Gary D., Aldape, Kenneth D., Largaespada, David A., Zadeh, Gelareh

“…Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive sarcoma, and a lethal neurofibromatosis type 1-related malignancy, with little progress…”
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Dose Effects of Orally Administered Spirulina Suspension on Colonic Microbiota in Healthy Mice by Hu, Jinlu, Li, Yaguang, Pakpour, Sepideh, Wang, Sufang, Pan, Zhenhong, Liu, Junhong, Wei, Qingxia, She, Junjun, Cang, Huaixing, Zhang, Rui Xue

“…Oral supplemented nutraceuticals derived from food sources are surmised to improve the human health through interaction with the gastrointestinal bacteria…”
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A novel piperidine identified by stem cell-based screening attenuates pulmonary arterial hypertension by regulating BMP2 and PTGS2 levels by Xing, Yanjiang, Zhao, Shuang, Wei, Qingxia, Gong, Shiqiang, Zhao, Xin, Zhou, Fang, Ai-Lamki, Rafia, Ortmann, Daniel, Du, Mingxia, Pedersen, Roger, Shang, Guangdong, Si, Shuyi, Morrell, Nicholas W, Yang, Jun

“…Genetic defects in bone morphogenetic protein type II receptor (BMPRII) signalling and inflammation contribute to the pathogenesis of pulmonary arterial…”
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Side population cells isolated from mesenchymal neoplasms have tumor initiating potential by WU, Colleen, QINGXIA WEI, UTOMO, Velani, NADESAN, Puviindran, WHETSTONE, Heather, KANDEL, Rita, WUNDER, Jay S, ALMAN, Benjamin A

“…Although many cancers are maintained by tumor-initiating cells, this has not been shown for mesenchymal tumors, in part due to the lack of unique surface…”
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Perk heterozygosity ameliorates chronic hypoxia-induced pulmonary hypertension and right ventricular hypertrophy in male rats by Wei, Qingxia, Li, Hanlu, Chen, Yibing, Xu, Xiang, Guo, Ge, Li, Xin, Shen, Yanying, Liu, Chunlei, He, Kunlun

“…Pulmonary hypertension (PH) is a rare and deadly disease characterized by remodeling of the pulmonary vasculature and increased pulmonary artery pressure…”
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Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth by Campbell, Veronica T, Nadesan, Puviindran, Ali, S Amanda, Wang, Chang Ye Yale, Whetstone, Heather, Poon, Raymond, Wei, Qingxia, Keilty, John, Proctor, Jennifer, Wang, Lauren W, Apte, Suneel S, McGovern, Karen, Alman, Benjamin A, Wunder, Jay S

“…Hedgehog (Hh) pathway inhibition in cancer has been evaluated in both the ligand-independent and ligand-dependent settings, where Hh signaling occurs either…”
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Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing by Cheon, Sophia S, Wei, Qingxia, Gurung, Ananta, Youn, Andrew, Bright, Tamara, Poon, Raymond, Whetstone, Heather, Guha, Abhijit, Alman, Benjamin A

“…After cutaneous injury, a variety of cell types are activated to reconstitute the epithelial and dermal components of the skin. {szligbeta}-Catenin plays…”
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Identification of serum proteins AHSG, FGA and APOA-I as diagnostic biomarkers for gastric cancer by Shi, Feiyu, Wu, Hong, Qu, Kai, Sun, Qi, Li, Fanni, Shi, Chengxin, Li, Yaguang, Xiong, Xiaofan, Qin, Qian, Yu, Tianyu, Jin, Xin, Cheng, Liang, Wei, Qingxia, Li, Yingchao, She, Junjun

“…The development of clinically accessible biomarkers is critical for the early diagnosis of gastric cancer (GC) in patients. High-throughput proteomics…”
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A primary DICER1-sarcoma with KRAS and TP53 mutations in a child with suspected ECCL by Yang, Kaiyun, Wang, Justin, Kanwar, Nisha, Villani, Anita, Ajani, Olufemi, Fleming, Adam, Patil, Vikas, Mamatjan, Yasin, Wei, Qingxia, Malkin, David, Shlien, Adam, Zadeh, Gelareh, Provias, John

“…A child had been followed since infancy by our multi-disciplinary neuro-oncology clinic with annual magnetic resonance imaging (MRI) under the presumed…”
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Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype by Sato, Shingo, Tang, Yuning J., Wei, Qingxia, Hirata, Makoto, Weng, Angela, Han, Ilkyu, Okawa, Atsushi, Takeda, Shu, Whetstone, Heather, Nadesan, Puvindran, Kirsch, David G., Wunder, Jay S., Alman, Benjamin A.

“…The cell of origin for most mesenchymal tumors is unclear. One cell type that contributes to this lineages is the pericyte, a cell expressing Ng2/Cspg4. Using…”
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Hedgehog and Notch signaling regulate self-renewal of undifferentiated pleomorphic sarcomas by Wang, Chang Ye Yale, Wei, Qingxia, Han, Ilkyu, Sato, Shingo, Ghanbari-Azarnier, Ronak, Whetstone, Heather, Poon, Raymond, Hu, Jiayi, Zheng, Feifei, Zhang, Phil, Wang, Weishi, Wunder, Jay S, Alman, Benjamin A

“…Like many solid tumors, sarcomas are heterogeneous and include a small fraction of the so-called side population (SP) cells with stem-like tumor-initiating…”
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Novel Targets in a High-Altitude Pulmonary Hypertension Rat Model Based on RNA-seq and Proteomics by Xu, Xiang, Li, Hanlu, Wei, Qingxia, Li, Xin, Shen, Yanying, Guo, Ge, Chen, Yibing, He, Kunlun, Liu, Chunlei

“…High-altitude pulmonary hypertension (HAPH) is a complication arising from an inability to acclimatize to high altitude and is associated with high morbidity…”
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Assessment of Requirements for IL-15 and IFN Regulatory Factors in Uterine NK Cell Differentiation and Function During Pregnancy by Ashkar, Ali A, Black, Gordon P, Wei, Qingxia, He, Hong, Liang, Luchuan, Head, Judith R, Croy, B. Anne

“…In mouse and human, precursors of NK cell lineage home to decidualizing uteri. To assess the requirement for IL-15, an essential cytokine for NK…”
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Identification of CD146 as a marker enriched for tumor-propagating capacity reveals targetable pathways in primary human sarcoma by Wei, Qingxia, Tang, Yuning J, Voisin, Veronique, Sato, Shingo, Hirata, Makoto, Whetstone, Heather, Han, Ilkyu, Ailles, Laurie, Bader, Gary D, Wunder, Jay, Alman, Benjamin A

“…Tumor-propagating cells (TPCs) are believed to drive cancer initiation, progression and recurrence. These cells are characterized by enhanced tumorigenicity…”
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High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model by QINGXIA WEI, CLARKE, Laura, PUREV, Enkhtsetseg, LAVOIE, Jean-Francois, BAJENARU, M. Livia, SHANNON, Patrick, HERLYN, Dorothee, KAPLAN, David, HENKELMAN, R. Mark, GUTMANN, David H, GUHA, Abhijit, SCHEIDENHELM, Danielle K, BAOPING QIAN, TONG, Amanda, SABHA, Nesrin, KARIM, Zia, BOCK, Nicholas A, RETI, Robert, SWOBODA, Rolf

“…High-grade gliomas are devastating brain tumors associated with a mean survival of <50 weeks. Two of the most common genetic changes observed in these tumors…”
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