Search Results - "Wei, Lisa L"

Retinal AAV8-RS1 Gene Therapy for X-Linked Retinoschisis: Initial Findings from a Phase I/IIa Trial by Intravitreal Delivery by Cukras, Catherine, Wiley, Henry E., Jeffrey, Brett G., Sen, H. Nida, Turriff, Amy, Zeng, Yong, Vijayasarathy, Camasamudram, Marangoni, Dario, Ziccardi, Lucia, Kjellstrom, Sten, Park, Tae Kwon, Hiriyanna, Suja, Wright, J. Fraser, Colosi, Peter, Wu, Zhijian, Bush, Ronald A., Wei, Lisa L., Sieving, Paul A.

“…This study evaluated the safety and tolerability of ocular RS1 adeno-associated virus (AAV8-RS1) gene augmentation therapy to the retina of participants with…”
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Ocular localization and transduction by adenoviral vectors are serotype-dependent and can be modified by inclusion of RGD fiber modifications by Ueyama, Kazuhiro, Mori, Keisuke, Shoji, Takuhei, Omata, Hidekazu, Gehlbach, Peter L, Brough, Douglas E, Wei, Lisa L, Yoneya, Shin

“…To evaluate localization and transgene expression from adenoviral vector of serotypes 5, 35, and 28, ± an RGD motif in the fiber following intravitreal or…”
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“Para-retinal” Vector Administration into the Deep Vitreous Enhances Retinal Transgene Expression by Zeng, Yong, Boyd, Ryan, Bartoe, Joshua, Wiley, Henry E., Marangoni, Dario, Wei, Lisa L., Sieving, Paul A.

“…Intravitreal administration for human adeno-associated vector (AAV) delivery is easier and less traumatic to ocular tissues than subretinal injection, but it…”
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Ocular and systemic safety of a recombinant AAV8 vector for X-linked retinoschisis gene therapy: GLP studies in rabbits and Rs1-KO mice by Marangoni, Dario, Bush, Ronald A, Zeng, Yong, Wei, Lisa L, Ziccardi, Lucia, Vijayasarathy, Camasamudram, Bartoe, Joshua T, Palyada, Kiran, Santos, Maria, Hiriyanna, Suja, Wu, Zhijian, Colosi, Peter, Sieving, Paul A

“…X-linked retinoschisis (XLRS) is a retinal disease caused by mutations in the gene encoding the protein retinoschisin (RS1) and is one of the most common…”
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Retinal Neuroprotection against Ischemic Injury Mediated by Intraocular Gene Transfer of Pigment Epithelium-Derived Factor by Takita, Hiroyasu, Yoneya, Shin, Gehlbach, Peter L, Duh, Elia J, Wei, Lisa L, Mori, Keisuke

“…To determine whether intraocular gene transfer of pigment epithelium-derived factor (PEDF) protects the retina from ischemia-reperfusion injury. Four days…”
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Intraocular gene transfer of pigment epithelium-derived factor rescues photoreceptors from light-induced cell death by Imai, Daisuke, Yoneya, Shin, Gehlbach, Peter L., Wei, Lisa L., Mori, Keisuke

“…In this study, we investigated whether intraocular gene transfer of pigment epithelium‐derived factor (PEDF) ameliorates the extent of light‐induced…”
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Immune function in X-linked retinoschisis subjects in an AAV8-RS1 phase I/IIa gene therapy trial by Mishra, Alaknanda, Vijayasarathy, Camasamudram, Cukras, Catherine A., Wiley, Henry E., Sen, H. Nida, Zeng, Yong, Wei, Lisa L., Sieving, Paul A.

“…This study explored systemic immune changes in 11 subjects with X-linked retinoschisis (XLRS) in a phase I/IIa adeno-associated virus 8 (AAV8)-RS1 gene therapy…”
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CNGB3-achromatopsia clinical trial with CNTF: diminished rod pathway responses with no evidence of improvement in cone function by Zein, Wadih M, Jeffrey, Brett G, Wiley, Henry E, Turriff, Amy E, Tumminia, Santa J, Tao, Weng, Bush, Ronald A, Marangoni, Dario, Wen, Rong, Wei, Lisa L, Sieving, Paul A

“…Ciliary neurotrophic factor (CNTF) protects rod photoreceptors from retinal degenerative disease in multiple nonhuman models. Thus far, CNTF has failed to…”
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Intravitreal Ciliary Neurotrophic Factor Transiently Improves Cone-Mediated Function in a CNGB3-/- Mouse Model of Achromatopsia by Marangoni, Dario, Vijayasarathy, Camasamudram, Bush, Ronald A, Wei, Lisa L, Wen, Rong, Sieving, Paul A

“…Ciliary neurotrophic factor (CNTF) was recently shown to augment cone function in CNGB3 mutant achromat dogs. However, testing CNTF-releasing implant in human…”
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Convergence of Human Genetics and Animal Studies: Gene Therapy for X-Linked Retinoschisis by Bush, Ronald A, Wei, Lisa L, Sieving, Paul A

“…Retinoschisis is an X-linked recessive genetic disease that leads to vision loss in males. X-linked retinoschisis (XLRS) typically affects young males;…”
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Adenoviral vector-delivered pigment epithelium-derived factor for neovascular age-related macular degeneration: results of a phase I clinical trial by Campochiaro, Peter A, Nguyen, Quan Dong, Shah, Syed Mahmood, Klein, Michael L, Holz, Eric, Frank, Robert N, Saperstein, David A, Gupta, Anurag, Stout, J Timothy, Macko, Jennifer, DiBartolomeo, Robert, Wei, Lisa L

“…Twenty-eight patients with advanced neovascular age-related macular degeneration (AMD) were given a single intravitreous injection of an E1-, partial E3-,…”
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Pigment epithelium-derived factor inhibits retinal and choroidal neovascularization by Mori, Keisuke, Duh, Elia, Gehlbach, Peter, Ando, Akira, Takahashi, Kyoichi, Pearlman, Joel, Mori, Keiko, Yang, Hoseong S., Zack, Donald J., Ettyreddy, Damodar, Brough, Douglas E., Wei, Lisa L., Campochiaro, Peter A.

“…In this study, we investigated whether overexpression of pigment epithelium‐derived factor (PEDF) by gene transfer can inhibit neovascularization by testing…”
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Preclinical safety evaluation of a recombinant AAV8 vector for X-linked retinoschisis after intravitreal administration in rabbits by Marangoni, Dario, Wu, Zhijian, Wiley, Henry E, Zeiss, Caroline J, Vijayasarathy, Camasamudram, Zeng, Yong, Hiriyanna, Suja, Bush, Ronald A, Wei, Lisa L, Colosi, Peter, Sieving, Paul A

“…X-linked retinoschisis (XLRS) is a retinal disease caused by mutations in the gene encoding the protein retinoschisin (RS1) and one of the most common causes…”
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Alternate serotype adenovector provides long-term therapeutic gene expression in the eye by Hamilton, Melissa M, Byrnes, Gordon A, Gall, Jason G, Brough, Douglas E, King, C Richter, Wei, Lisa L

“…To determine whether the duration of transgene expression from an alternate adenovector serotype, Ad35, can provide advantages over an Ad5 serotype vector…”
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Overexpression of KAI1 suppresses in vitro invasiveness and in vivo metastasis in breast cancer cells by Yang, X, Wei, L L, Tang, C, Slack, R, Mueller, S, Lippman, M E

“…KAI1 is a metastasis suppressor gene for human prostate cancer and is also involved in the progression of a variety of other human cancers. Previously, we have…”
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Repeat Administration of Proteins to the Eye With a Single Intraocular Injection of an Adenovirus Vector by McVey, Duncan, Hamilton, Melissa M, Hsu, Chi, King, C Richter, Brough, Douglas E, Wei, Lisa L

“…Delivery of therapeutic proteins, such as antiangiogenic proteins, to the eye is a demonstrated method for the control of age-related macular degeneration…”
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The role of lacrimal intubation in the management of facial trauma and tumor resection by SPINELLI, Henry M, SHAPIRO, Michael D, WEI, Lisa L, ELAHI, Ebrahim, HIRMAND, Haideh

“…Lacrimal drainage dysfunction is a common and problematic consequence of any pathologic process that interferes with the physiology or continuity of the…”
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Trans-scleral delivery of antiangiogenic proteins by Demetriades, Anna M, Deering, Tye, Liu, Hansheng, Lu, Lili, Gehlbach, Peter, Packer, Jonathan D, Mac Gabhann, Feilim, Popel, Aleksander S, Wei, Lisa L, Campochiaro, Peter A

“…In this study, we investigated the penetration of various proteins into the mouse eye after a periocular injection of the protein or an adenoviral vector (Ad)…”
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Persistent Expression of PEDF in the Eye Using High-capacity Adenovectors by Chen, Ping, Hamilton, Melissa, Thomas, Charles A, Kroeger, Kurt, Carrion, Miguel, MacGill, Randall S, Gehlbach, Peter, Brough, Douglas E, Wei, Lisa L, King, C Richter, Bruder, Joseph T

“…Ocular neovascularization, the growth of abnormal blood vessels in the eye, is a factor shared by the most common blinding diseases in developed countries…”
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Repeated Administration of Adenovector in the Eye Results in Efficient Gene Delivery by Hamilton, Melissa M, Brough, Douglas E, McVey, Duncan, Bruder, Joseph T, King, C. Richter, Wei, Lisa L

“…To determine whether repeat administration of an adenovector (Ad) into the eye results in efficient gene delivery and to test whether transgenes can be…”
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