Search Results - "Wehrli, Suzanne"

Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis by DeBerardinis, Ralph J, Mancuso, Anthony, Daikhin, Evgueni, Nissim, Ilana, Yudkoff, Marc, Wehrli, Suzanne, Thompson, Craig B

“…Tumor cell proliferation requires rapid synthesis of macromolecules including lipids, proteins, and nucleotides. Many tumor cells exhibit rapid glucose…”
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Towards quantification of myelin by solid-state MRI of the lipid matrix protons by Seifert, Alan C., Li, Cheng, Wilhelm, Michael J., Wehrli, Suzanne L., Wehrli, Felix W.

“…Direct assessment of myelin has the potential to reveal central nervous system abnormalities and serve as a means to follow patients with demyelinating…”
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Direct magnetic resonance detection of myelin and prospects for quantitative imaging of myelin density by Wilhelm, Michael J, Ong, Henry H, Wehrli, Suzanne L, Li, Cheng, Tsai, Ping-Huei, Hackney, David B, Wehrli, Felix W

“…Magnetic resonance imaging has previously demonstrated its potential for indirectly mapping myelin density, either by relaxometric detection of myelin water or…”
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Bi-component T2 analysis of bound and pore bone water fractions fails at high field strengths by Seifert, Alan C., Wehrli, Suzanne L., Wehrli, Felix W.

“…Osteoporosis involves the degradation of the bone's trabecular architecture, cortical thinning and enlargement of cortical pores. Increased cortical porosity…”
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Expression level and subcellular localization of heme oxygenase-1 modulates its cytoprotective properties in response to lung injury: a mouse model by Namba, Fumihiko, Go, Hayato, Murphy, Jennifer A, La, Ping, Yang, Guang, Sengupta, Shaon, Fernando, Amal P, Yohannes, Mekdes, Biswas, Chhanda, Wehrli, Suzanne L, Dennery, Phyllis A

“…Premature infants exposed to hyperoxia suffer acute and long-term pulmonary consequences. Nevertheless, neonates survive hyperoxia better than adults. The…”
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The Molecular and Metabolic Influence of Long Term Agmatine Consumption by Nissim, Itzhak, Horyn, Oksana, Daikhin, Yevgeny, Chen, Pan, Li, Changhong, Wehrli, Suzanne L., Nissim, Ilana, Yudkoff, Marc

“…Agmatine (AGM), a product of arginine decarboxylation, influences multiple physiologic and metabolic functions. However, the mechanism(s) of action, the impact…”
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A Surrogate Measure of Cortical Bone Matrix Density by Long T2‐Suppressed MRI by Seifert, Alan C, Li, Cheng, Wehrli, Suzanne L, Wehrli, Felix W

“…ABSTRACT Magnetic resonance has the potential to image and quantify two pools of water within bone: free water within the Haversian pore system (transverse…”
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The Ketogenic Diet Does Not Affect Growth of Hedgehog Pathway Medulloblastoma in Mice by Dang, Mai T, Wehrli, Suzanne, Dang, Chi V, Curran, Tom

“…The altered metabolism of cancer cells has long been viewed as a potential target for therapeutic intervention. In particular, brain tumors often display…”
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Indirect measurement of regional axon diameter in excised mouse spinal cord with q-space imaging: Simulation and experimental studies by Ong, Henry H., Wright, Alex C., Wehrli, Suzanne L., Souza, Andre, Schwartz, Eric D., Hwang, Scott N., Wehrli, Felix W.

“…Q-space imaging (QSI), a diffusion MRI technique, can provide quantitative tissue architecture information at cellular dimensions not amenable by conventional…”
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Tracking inflammation in the epileptic rat brain by bi-functional fluorescent and magnetic nanoparticles by Portnoy, Emma, Polyak, Boris, Inbar, Dorrit, Kenan, Gilad, Rai, Ahmad, Wehrli, Suzanne L, Roberts, Timothy P.L, Bishara, Ameer, Mann, Aniv, Shmuel, Miriam, Rozovsky, Katya, Itzhak, Gal, Hur, Tamir Ben, Magdassi, Shlomo, Ekstein, Dana, Eyal, Sara

“…Abstract Correct localization of epileptic foci can improve surgical outcome in patients with drug-resistant seizures. Our aim was to demonstrate that…”
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Effects of a glucokinase activator on hepatic intermediary metabolism: study with 13C-isotopomer-based metabolomics by Nissim, Itzhak, Horyn, Oksana, Nissim, Ilana, Daikhin, Yevgeny, Wehrli, Suzanne L, Yudkoff, Marc, Matschinsky, Franz M

“…GKAs (glucokinase activators) are promising agents for the therapy of Type 2 diabetes, but little is known about their effects on hepatic intermediary…”
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Magnetic Resonance Microimaging of Intraaxonal Water Diffusion in Live Excised Lamprey Spinal Cord by Takahashi, Masaya, Hackney, David B., Zhang, Guixin, Wehrli, Suzanne L., Wright, Alex C., O'Brien, William T., Uematsu, Hidemasa, Wehrli, Felix W., Selzer, Michael E.

“…Anisotropy of water diffusion in axon tracts, as determined by diffusion-weighted MRI, has been assumed to reflect the restriction of water diffusion across…”
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Implications of noise and resolution on mechanical properties of trabecular bone estimated by image-based finite-element analysis by Rajapakse, Chamith S., Magland, Jeremy, Zhang, X. Henry, Liu, X. Sherry, Wehrli, Suzanne L., Guo, X. Edward, Wehrli, Felix W.

“…Recent advances in micro‐magnetic resonance imaging (µMRI) now allow noninvasive assessment of mechanical properties of trabecular bone (TB) in vivo by micro…”
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Water Content Measured by Proton‐Deuteron Exchange NMR Predicts Bone Mineral Density and Mechanical Properties by Fernández‐Seara, Maria A, Wehrli, Suzanne L, Takahashi, Masaya, Wehrli, Felix W

“…NMR was used to measure matrix water content in normal and hypomineralized cortical bone. Water content showed an inverse relationship with mineral content,…”
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AMP promotes oxygen consumption and ATP synthesis in heart mitochondria through the adenylate kinase reaction: an NMR spectroscopy and polarography study by Doliba, Nicolai M., Babsky, Andriy M., Doliba, Nataliya M., Wehrli, Suzanne L., Osbakken, Mary D.

“…Adenylate kinase plays an important role in cellular energy homeostasis by catalysing the interconversion of adenine nucleotides. The goal of present study was…”
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The Diagnostic Accuracy of Ex Vivo MRI for Human Atherosclerotic Plaque Characterization by Shinnar, Meir, Fallon, John T, Wehrli, Suzanne, Levin, Michael, Dalmacy, Dolcine, Fayad, Zahi A, Badimon, Juan J, Harrington, Martin, Harrington, Elizabeth, Fuster, Valentin

“…Recent evidence indicates that the type of atherosclerotic plaque, rather than the degree of obstruction to flow, is an important determinant of the risk of…”
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3-Isobutylmethylxanthine Inhibits Hepatic Urea Synthesis: PROTECTION BY AGMATINE by Nissim, Itzhak, Horyn, Oksana, Nissim, Ilana, Daikhin, Yevgeny, Wehrli, Suzanne L, Yudkoff, Marc

“…We previously showed that agmatine stimulated hepatic ureagenesis. In this study, we sought to determine whether the action of agmatine is mediated via cAMP…”
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Diffusion of Exchangeable Water in Cortical Bone Studied by Nuclear Magnetic Resonance by Fernández-Seara, Maria A., Wehrli, Suzanne L., Wehrli, Felix W.

“…The rate-limiting step in the delivery of nutrients to osteocytes and the removal of cellular waste products is likely diffusion. The transport of osteoid…”
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31P NMR relaxation of cortical bone mineral at multiple magnetic field strengths and levels of demineralization by Seifert, Alan C., Wright, Alexander C., Wehrli, Suzanne L., Ong, Henry H., Li, Cheng, Wehrli, Felix W.

“…Recent work has shown that solid‐state 1H and 31P MRI can provide detailed insight into bone matrix and mineral properties, thereby potentially enabling…”
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Metabolic and ionic coupling factors in amino acid-stimulated insulin release in pancreatic beta-HC9 cells by Doliba, Nicolai M, Wehrli, Suzanne L, Vatamaniuk, Marko Z, Qin, Wei, Buettger, Carol W, Collins, Heather W, Matschinsky, Franz M

“…Fuel stimulation of insulin secretion from pancreatic beta-cells is thought to be mediated by metabolic coupling factors that are generated by energized…”
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