Search Results - "Wehrens, Ellen J."

High-resolution 3D imaging of fixed and cleared organoids by Dekkers, Johanna F., Alieva, Maria, Wellens, Lianne M., Ariese, Hendrikus C. R., Jamieson, Paul R., Vonk, Annelotte M., Amatngalim, Gimano D., Hu, Huili, Oost, Koen C., Snippert, Hugo J. G., Beekman, Jeffrey M., Wehrens, Ellen J., Visvader, Jane E., Clevers, Hans, Rios, Anne C.

“…In vitro 3D organoid systems have revolutionized the modeling of organ development and diseases in a dish. Fluorescence microscopy has contributed to the…”
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Human breast tissue engineering in health and disease by Buchholz, Maj-Britt, Scheerman, Demi I, Levato, Riccardo, Wehrens, Ellen J, Rios, Anne C

“…The human mammary gland represents a highly organized and dynamic tissue, uniquely characterized by postnatal developmental cycles. During pregnancy and…”
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Interleukin-27R Signaling Mediates Early Viral Containment and Impacts Innate and Adaptive Immunity after Chronic Lymphocytic Choriomeningitis Virus Infection by Harker, James A, Wong, Kurt A, Dallari, Simone, Bao, Phuc, Dolgoter, Aleksandr, Jo, Yeara, Wehrens, Ellen J, Macal, Monica, Zuniga, Elina I

“…Chronic viral infections represent a major challenge to the host immune response, and a unique network of immunological elements, including cytokines, are…”
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IL-27 regulates the number, function and cytotoxic program of antiviral CD4 T cells and promotes cytomegalovirus persistence by Wehrens, Ellen J, Wong, Kurt A, Gupta, Ankan, Khan, Ayesha, Benedict, Chris A, Zuniga, Elina I

“…The role of IL-27 in antiviral immunity is still incompletely understood, especially in the context of chronic viruses that induce a unique environment in…”
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Early transcriptional and epigenetic divergence of CD8+ T cells responding to acute versus chronic infection by Quezada, Lauren K, Jin, Wenhao, Liu, Yi Chia, Kim, Eleanor S, He, Zhaoren, Indralingam, Cynthia S, Tysl, Tiffani, Labarta-Bajo, Lara, Wehrens, Ellen J, Jo, Yeara, Kazane, Katelynn R, Hattori, Christopher, Zuniga, Elina I, Yeo, Gene W, Chang, John T

“…During a microbial infection, responding CD8+ T cells give rise to effector cells that provide acute host defense and memory cells that provide sustained…”
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Invaders Exposed: Understanding and Targeting Tumor Cell Invasion in Diffuse Intrinsic Pontine Glioma by Kluiver, T A, Alieva, M, van Vuurden, D G, Wehrens, Ellen J, Rios, Anne C

“…Diffuse Intrinsic Pontine Glioma (DIPG) is a rare, highly aggressive pediatric brain tumor that originates in the pons. DIPG is untreatable and universally…”
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A multispectral 3D live organoid imaging platform to screen probes for fluorescence guided surgery by Jeremiasse, Bernadette, van Ineveld, Ravian L, Bok, Veerle, Kleinnijenhuis, Michiel, de Blank, Sam, Alieva, Maria, Johnson, Hannah R, van Vliet, Esmée J, Zeeman, Amber L, Wellens, Lianne M, Llibre-Palomar, Gerard, Barrera Román, Mario, Di Maggio, Alessia, Dekkers, Johanna F, Oliveira, Sabrina, Vahrmeijer, Alexander L, Molenaar, Jan J, Wijnen, Marc HWA, van der Steeg, Alida FW, Wehrens, Ellen J, Rios, Anne C

“…Achieving complete tumor resection is challenging and can be improved by real-time fluorescence-guided surgery with molecular-targeted probes. However,…”
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How a lab happiness programme is helping me through the COVID-19 crisis by Wehrens, Ellen J

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The CD28/CTLA-4-B7 Signaling Pathway Is Involved in Both Allergic Sensitization and Tolerance Induction to Orally Administered Peanut Proteins by van Wijk, Femke, Nierkens, Stefan, de Jong, Wilco, Wehrens, Ellen J. M, Boon, Louis, van Kooten, Peter, Knippels, Leon M. J, Pieters, Raymond

“…Dendritic cells are believed to play an essential role in regulating the balance between immunogenic and tolerogenic responses to mucosal Ags by controlling T…”
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Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing by Kakaradov, Boyko, Arsenio, Janilyn, Widjaja, Christella E, He, Zhaoren, Aigner, Stefan, Metz, Patrick J, Yu, Bingfei, Wehrens, Ellen J, Lopez, Justine, Kim, Stephanie H, Zuniga, Elina I, Goldrath, Ananda W, Chang, John T, Yeo, Gene W

“…CD8 + T cells rapidly commence transcriptional changes after antigenic encounter and priming. Yeo and colleagues find substantial transcriptional heterogeneity…”
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Long-term culture, genetic manipulation and xenotransplantation of human normal and breast cancer organoids by Dekkers, Johanna F., van Vliet, Esmée J., Sachs, Norman, Rosenbluth, Jennifer M., Kopper, Oded, Rebel, Heggert G., Wehrens, Ellen J., Piani, Carol, Visvader, Jane E., Verissimo, Carla S., Boj, Sylvia F., Brugge, Joan S., Clevers, Hans, Rios, Anne C.

“…Organoid technology has revolutionized the study of human organ development, disease and therapy response tailored to the individual. Although detailed…”
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Human regulatory T cell suppressive function is independent of apoptosis induction in activated effector T cells by Vercoulen, Yvonne, Wehrens, Ellen J, van Teijlingen, Nienke H, de Jager, Wilco, Beekman, Jeffrey M, Prakken, Berent J

“…CD4(+)CD25(+)FOXP3(+) Regulatory T cells (Treg) play a central role in the immune balance to prevent autoimmune disease. One outstanding question is how Tregs…”
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Bridging live-cell imaging and next-generation cancer treatment by Alieva, Maria, Wezenaar, Amber K. L., Wehrens, Ellen J., Rios, Anne C.

“…By providing spatial, molecular and morphological data over time, live-cell imaging can provide a deeper understanding of the cellular and signalling events…”
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T cells out of control—impaired immune regulation in the inflamed joint by Wehrens, Ellen J., Prakken, Berent J., van Wijk, Femke

“…In this Review, the authors summarize the latest findings on changes in effector T-cell homeostasis in autoimmune disease and discuss how mechanisms that…”
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Uncovering the mode of action of engineered T cells in patient cancer organoids by Dekkers, Johanna F., Alieva, Maria, Cleven, Astrid, Keramati, Farid, Wezenaar, Amber K. L., van Vliet, Esmée J., Puschhof, Jens, Brazda, Peter, Johanna, Inez, Meringa, Angelo D., Rebel, Heggert G., Buchholz, Maj-Britt, Barrera Román, Mario, Zeeman, Amber L., de Blank, Sam, Fasci, Domenico, Geurts, Maarten H., Cornel, Annelisa M., Driehuis, Else, Millen, Rosemary, Straetemans, Trudy, Nicolasen, Mara J. T., Aarts-Riemens, Tineke, Ariese, Hendrikus C. R., Johnson, Hannah R., van Ineveld, Ravian L., Karaiskaki, Froso, Kopper, Oded, Bar-Ephraim, Yotam E., Kretzschmar, Kai, Eggermont, Alexander M. M., Nierkens, Stefan, Wehrens, Ellen J., Stunnenberg, Henk G., Clevers, Hans, Kuball, Jürgen, Sebestyen, Zsolt, Rios, Anne C.

“…Extending the success of cellular immunotherapies against blood cancers to the realm of solid tumors will require improved in vitro models that reveal…”
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Self-Renewal and Toll-like Receptor Signaling Sustain Exhausted Plasmacytoid Dendritic Cells during Chronic Viral Infection by Macal, Monica, Jo, Yeara, Dallari, Simone, Chang, Aaron Y., Dai, Jihong, Swaminathan, Shobha, Wehrens, Ellen J., Fitzgerald-Bocarsly, Patricia, Zúñiga, Elina I.

“…Although characterization of T cell exhaustion has unlocked powerful immunotherapies, the mechanisms sustaining adaptations of short-lived innate cells to…”
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Autologous stem cell transplantation aids autoimmune patients by functional renewal and TCR diversification of regulatory T cells by Delemarre, Eveline M., van den Broek, Theo, Mijnheer, Gerdien, Meerding, Jenny, Wehrens, Ellen J., Olek, Sven, Boes, Marianne, van Herwijnen, Martijn J.C., Broere, Femke, van Royen, Annet, Wulffraat, Nico M., Prakken, Berent J., Spierings, Eric, van Wijk, Femke

“…Autologous hematopoietic stem cell transplantation (HSCT) is increasingly considered for patients with severe autoimmune diseases whose prognosis is poor with…”
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3D imaging for driving cancer discovery by van Ineveld, Ravian L, van Vliet, Esmée J, Wehrens, Ellen J, Alieva, Maria, Rios, Anne C

“…Our understanding of the cellular composition and architecture of cancer has primarily advanced using 2D models and thin slice samples. This has granted…”
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TGF-β receptor maintains CD4 T helper cell identity during chronic viral infections by Lewis, Gavin M, Wehrens, Ellen J, Labarta-Bajo, Lara, Streeck, Hendrik, Zuniga, Elina I

“…Suppression of CD8 and CD4 T cells is a hallmark in chronic viral infections, including hepatitis C and HIV. While multiple pathways are known to inhibit CD8 T…”
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Multispectral confocal 3D imaging of intact healthy and tumor tissue using mLSR-3D by van Ineveld, Ravian L., Collot, Raphaël, Román, Mario Barrera, Pagliaro, Anna, Bessler, Nils, Ariese, Hendrikus C. R., Kleinnijenhuis, Michiel, Kool, Marcel, Alieva, Maria, Chuva de Sousa Lopes, Susana M., Wehrens, Ellen J., Rios, Anne C.

“…Revealing the 3D composition of intact tissue specimens is essential for understanding cell and organ biology in health and disease. State-of-the-art 3D…”
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