Search Results - "Wehkamp, J."

Innate immune dysfunction in inflammatory bowel disease by Gersemann, M., Wehkamp, J., Stange, E. F.

“…  Gersemann M, Wehkamp J, Stange EF (Robert Bosch Hospital, Stuttgart; Dr. Margarete Fischer‐Bosch Institute of Clinical Pharmacology, Stuttgart and…”
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Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments by Ehmann, D., Wendler, J., Koeninger, L., Larsen, I. S., Klag, T., Berger, J., Marette, A., Schaller, M., Stange, E. F., Malek, N. P., Jensen, B. A. H., Wehkamp, J.

“…Antimicrobial peptides, in particular α-defensins expressed by Paneth cells, control microbiota composition and play a key role in intestinal barrier function…”
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Probiotic lactobacilli and VSL#3 induce enterocyte β-defensin 2 by Schlee, M, Harder, J, Köten, B, Stange, E.F, Wehkamp, J, Fellermann, K

“…Recent evidence suggests that probiotic bacteria may stabilize gut barrier function via induction of anti-microbial peptides such as defensins. This study…”
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Paneth cell α-defensin 6 (HD-6) is an antimicrobial peptide by Schroeder, B O, Ehmann, D, Precht, J C, Castillo, P A, Küchler, R, Berger, J, Schaller, M, Stange, E F, Wehkamp, J

“…Defensins protect human barriers from commensal and pathogenic microorganisms. Human α-defensin 6 (HD-6) is produced exclusively by small intestinal Paneth…”
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Decreased Paneth cell defensin expression in ileal Crohn's disease is independent of inflammation, but linked to the NOD2 1007fs genotype by Bevins, C L, Stange, E F, Wehkamp, J

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Bacterial Periplasmic Oxidoreductases Control the Activity of Oxidized Human Antimicrobial β-Defensin 1 by Wendler, J, Ehmann, D, Courth, L, Schroeder, B O, Malek, N P, Wehkamp, J

“…The antimicrobial peptide human β-defensin 1 (hBD1) is continuously produced by epithelial cells in many tissues. Compared to other defensins, hBD1 has only…”
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Barrier dysfunction due to distinct defensin deficiencies in small intestinal and colonic Crohn's disease by Wehkamp, J, Koslowski, M, Wang, G, Stange, E F

“…Defensins are endogenous antibiotics with broad microbicidal activity. A disturbed antimicrobial defense, as provided by Paneth and other epithelial defensins,…”
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NOD2 (CARD15) mutations in Crohn’s disease are associated with diminished mucosal α-defensin expression by Wehkamp, J, Harder, J, Weichenthal, M, Schwab, M, Schäffeler, E, Schlee, M, Herrlinger, K R, Stallmach, A, Noack, F, Fritz, P, Schröder, J M, Bevins, C L, Fellermann, K, Stange, E F

“…Background: Mutations in NOD2, a putative intracellular receptor for bacterial peptidoglycans, are associated with a subset of Crohn’s disease but the…”
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Probiotic E. coli treatment mediates antimicrobial human β-defensin synthesis and fecal excretion in humans by Möndel, M, Schroeder, B O, Zimmermann, K, Huber, H, Nuding, S, Beisner, J, Fellermann, K, Stange, E F, Wehkamp, J

“…Inducible epithelial human β-defensins (hBD) play an important role in intestinal barrier function. In vitro studies showed that clinically effective…”
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Infliximab as rescue medication for patients with severe ulcerative/indeterminate colitis refractory to tacrolimus by HERRLINGER, K. R., BARTHEL, D. N., SCHMIDT, K. J., BÜNING, J., BARTHEL, C. S., WEHKAMP, J., STANGE, E. F., FELLERMANN, K.

“…Aliment Pharmacol Ther 31, 1036–1041 Summary Background  The calcineurin inhibitor tacrolimus and the anti‐TNF‐antibody infliximab are established options in…”
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Cell-mediated reduction of human β-defensin 1: a major role for mucosal thioredoxin by Jaeger, S U, Schroeder, B O, Meyer-Hoffert, U, Courth, L, Fehr, S N, Gersemann, M, Stange, E F, Wehkamp, J

“…Human β-defensin 1 (hBD-1) is an antimicrobial peptide expressed by epithelia and hematopoietic cells. We demonstrated recently that hBD-1 shows activity…”
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A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa by Kotarsky, K, Sitnik, K M, Stenstad, H, Kotarsky, H, Schmidtchen, A, Koslowski, M, Wehkamp, J, Agace, W W

“…Intestinal-derived chemokines have a central role in orchestrating immune cell influx into the normal and inflamed intestine. Here, we identify the chemokine…”
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S230: HUMAN ΒETA‐DEFENSIN 2 TREATMENT MODULATES THE INTESTINAL MICROBIOME AND THE ALLOGENEIC T CELL RESPONSE TO LIMIT ACUTE GRAFT‐VERSUS‐HOST DISEASE by Rückert, T., Andrieux, G., Boerries, M., Woessner, N. M., Minguet, S., Doetsch, S., Aumann, K., Schiff, M, Braun, L. M., Haring, E., Siranosian, B. A., Bhatt, A. S., Nordkild, P., Wehkamp, J., Jensen, B. A. H., Duyster, J., Zeiser, R., Köhler, N.

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Influence of standard treatment on ileal and colonic antimicrobial defensin expression in active Crohn’s disease by KÜBLER, I., KOSLOWSKI, M. J., GERSEMANN, M., FELLERMANN, K., BEISNER, J., BECKER, S., ROTHFUSS, K., HERRLINGER, K. R., STANGE, E. F., WEHKAMP, J.

“…Summary Background  Crohn’s Disease (CD), a chronic intestinal inflammation, is currently treated primarily by therapeutics which are directed against…”
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Human beta-defensin 1: from defence to offence by Schroeder, B O, Stange, E F, Wehkamp, J

“…The human gut is colonised by about one kilogram of commensal bacteria. These microorganisms are a potential threat, thus an efficient defence system is…”
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Chronic Heavy Alcohol Use is Associated with Upregulated Paneth Cell Antimicrobials in Gastric Mucosa by Ostaff, M J, Schäfer, C, Courth, L, Stebe, S R D, Ott, G, Stange, E F, Wehkamp, J

“…How alcohol consumption affects the integrity and the defense mechanisms of the mucosa in the upper gastrointestinal tract is largely unknown. We examined the…”
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Innate immunity and colonic inflammation: Enhanced expression of epithelial α-defensins by WEHKAMP, J, SCHWIND, B, HERRLINGER, K. R, BAXMANN, S, SCHMIDT, K, DUCHROW, M, WOHLSCHLÄGER, C, FELLER, A. C, STANGE, E. F, FELLERMANN, K

“…Human alpha-defensins contribute to local intestinal host defense as part of innate immunity and may be of major relevance in microbial infection and chronic…”
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Defensin pattern in chronic gastritis: HBD-2 is differentially expressed with respect to Helicobacter pylori status by Wehkamp, J, Schmidt, K, Herrlinger, K R, Baxmann, S, Behling, S, Wohlschläger, C, Feller, A C, Stange, E F, Fellermann, K

“…Background/Aims: Recent reports have suggested that Helicobacter pylori infection induces the mucosal antibiotic peptide human β defensin 2 (HBD-2). Therefore,…”
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Defensin-immunology in inflammatory bowel disease by Wehkamp, J., Stange, E.F., Fellermann, K.

“…Defensins are endogenous antibiotics with microbicidal activity against Gram-negative and Gram-positive bacteria, fungi, enveloped viruses and protozoa. A…”
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P803 Different antimicrobial activity of beta defensins and colonic biopsy extracts against aerobic and anaerobic bacterial strains of the gastrointestinal tract by Nuding, S, Zabel, L, Fellermann, K, Wehkamp, J, Mueller, H.A.G, Stange, F.E

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