Search Results - "Weh, Katherine"

Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis by Cheng, Gang, Zhang, Qi, Pan, Jing, Lee, Yongik, Ouari, Olivier, Hardy, Micael, Zielonka, Monika, Myers, Charles R., Zielonka, Jacek, Weh, Katherine, Chang, Andrew C., Chen, Guoan, Kresty, Laura, Kalyanaraman, Balaraman, You, Ming

“…Lung cancer often has a poor prognosis, with brain metastases a major reason for mortality. We modified lonidamine (LND), an antiglycolytic drug with limited…”
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Expression, modulation, and clinical correlates of the autophagy protein Beclin-1 in esophageal adenocarcinoma by Weh, Katherine M., Howell, Amy B., Kresty, Laura A.

“…Esophageal adenocarcinoma (EAC) is characterized by rapidly increasing incidence and mortality rates and poor survival. Efficacious preventive and treatment…”
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Cranberries and Cancer: An Update of Preclinical Studies Evaluating the Cancer Inhibitory Potential of Cranberry and Cranberry Derived Constituents by Weh, Katherine M, Clarke, Jennifer, Kresty, Laura A

“…Cranberries are rich in bioactive constituents reported to influence a variety of health benefits, ranging from improved immune function and decreased…”
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Cranberry Polyphenols in Esophageal Cancer Inhibition: New Insights by Weh, Katherine M, Zhang, Yun, Howard, Connor L, Howell, Amy B, Clarke, Jennifer L, Kresty, Laura A

“…Esophageal adenocarcinoma (EAC) is a cancer characterized by rapidly rising incidence and poor survival, resulting in the need for new prevention and treatment…”
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Cranberry proanthocyanidins inhibit esophageal adenocarcinoma in vitro and in vivo through pleiotropic cell death induction and PI3K/AKT/mTOR inactivation by Kresty, Laura A, Weh, Katherine M, Zeyzus-Johns, Bree, Perez, Laura N, Howell, Amy B

“…Cranberries are rich in bioactive constituents known to improve urinary tract health and more recent evidence supports cranberries possess cancer inhibitory…”
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Cranberry Proanthocyanidins Mitigate Reflux-Induced Transporter Dysregulation in an Esophageal Adenocarcinoma Model by Zhang, Yun, Weh, Katherine M, Tripp, Bridget A, Clarke, Jennifer L, Howard, Connor L, Sunilkumar, Shruthi, Howell, Amy B, Kresty, Laura A

“…We recently reported that cranberry proanthocyanidins (C-PACs) inhibit esophageal adenocarcinoma (EAC) by 83% through reversing reflux-induced bacterial,…”
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Disparities in Head and Neck Cancer: A Case for Chemoprevention with Vitamin D by Ibrahimovic, Mirela, Franzmann, Elizabeth, Mondul, Alison M, Weh, Katherine M, Howard, Connor, Hu, Jennifer J, Goodwin, W Jarrard, Kresty, Laura A

“…Blacks experience disproportionate head and neck cancer (HNC) recurrence and mortality compared to Whites. Overall, vitamin D status is inversely associated to…”
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Proanthocyanidins mitigate bile acid‐induced changes in GSTT2 levels in a panel of racially diverse patient‐derived primary esophageal cell cultures by Weh, Katherine M., Turgeon, Danielle K., Rubenstein, Joel H., Clarke, Jennifer L., Howell, Amy B., Chang, Andrew C., Kresty, Laura A.

“…Persistent and symptomatic reflux of gastric and duodenal contents, known as gastroesophageal reflux disease (GERD), is the strongest risk factor for…”
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Characterizing isoform switching events in esophageal adenocarcinoma by Zhang, Yun, Weh, Katherine M., Howard, Connor L., Riethoven, Jean-Jack, Clarke, Jennifer L., Lagisetty, Kiran H., Lin, Jules, Reddy, Rishindra M., Chang, Andrew C., Beer, David G., Kresty, Laura A.

“…Isoform switching events with predicted functional consequences are common in many cancers, but characterization of switching events in esophageal…”
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Constitutively Higher Level of GSTT2 in Esophageal Tissues From African Americans Protects Cells Against DNA Damage by Ferrer-Torres, Daysha, Nancarrow, Derek J., Steinberg, Hannah, Wang, Zhuwen, Kuick, Rork, Weh, Katherine M., Mills, Ryan E., Ray, Dipankar, Ray, Paramita, Lin, Jules, Chang, Andrew C., Reddy, Rishindra M., Orringer, Mark B., Canto, Marcia I., Shaheen, Nicholas J., Kresty, Laura A., Chak, Amitabh, Wang, Thomas D., Rubenstein, Joel H., Beer, David G.

“…African American and European American individuals have a similar prevalence of gastroesophageal reflux disease (GERD), yet esophageal adenocarcinoma (EAC)…”
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Rod photoreceptor-specific deletion of cytosolic aspartate aminotransferase, GOT1, causes retinal degeneration by Subramanya, Shubha, Goswami, Moloy T, Miller, Nicholas, Weh, Eric, Chaudhury, Sraboni, Zhang, Li, Andren, Anthony, Hager, Heather, Weh, Katherine M, Lyssiotis, Costas A, Besirli, Cagri G, Wubben, Thomas J

“…Photoreceptor cell death is the cause of vision loss in many forms of retinal disease. Metabolic dysfunction within the outer retina has been shown to be an…”
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Prebiotic proanthocyanidins inhibit bile reflux-induced esophageal adenocarcinoma through reshaping the gut microbiome and esophageal metabolome by Weh, Katherine M, Howard, Connor L, Zhang, Yun, Tripp, Bridget A, Clarke, Jennifer L, Howell, Amy B, Rubenstein, Joel H, Abrams, Julian A, Westerhoff, Maria, Kresty, Laura A

“…The gut and local esophageal microbiome progressively shift from healthy commensal bacteria to inflammation-linked pathogenic bacteria in patients with…”
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Mitochondria-targeted magnolol inhibits OXPHOS, proliferation, and tumor growth via modulation of energetics and autophagy in melanoma cells by Cheng, Gang, Hardy, Micael, Zielonka, Jacek, Weh, Katherine, Zielonka, Monika, Boyle, Kathleen A., Abu Eid, Mahmoud, McAllister, Donna, Bennett, Brian, Kresty, Laura A., Dwinell, Michael B., Kalyanaraman, Balaraman

“…•Mito-magnolol is nearly 100-fold more effective than magnolol.•Mito-magnolol inhibits mitochondrial respiration and melanoma cell proliferation.•Mito-magnolol…”
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Abstract 2593: Racially diverse primary esophageal cell cultures for evaluating mitigation of bile-induced injury by Weh, Katherine M., Turgeon, Danielle K., Howell, Amy, Kresty, Laura A.

“…Persistent and symptomatic reflux of gastric and duodenal contents, known as gastroesophageal reflux disease (GERD), is the strongest risk factor for EAC…”
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Abstract 5077: Proteomic profiling reveals chemopreventive targets in esophageal adenocarcinoma by Weh, Katherine M., Howard, Connor L., Howell, Amy B., Clarke, Jennifer L., Kresty, Laura A.

“…Esophageal adenocarcinoma (EAC) is characterized by rising incidence rates and high mortality due to late stage diagnosis and a lack of efficacious options for…”
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Abstract 6588: Omics integration provides insight into esophageal cancer inhibitory mechanisms of a cranberry extract by Weh, Katherine M., Howard, Connor L., Tripp, Bridget A., Clarke, Jennifer L., Howell, Amy B., Kresty, Laura A.

“…Our laboratory studies chemoprevention of esophageal adenocarcinoma (EAC) through utilization of the rat esophagogastroduodenal anastomosis (EGDA) surgical…”
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Abstract 1418: Proanthocyanidins enhance chemotherapy-induced esophageal adenocarcinoma cell death by Zhang, Yun, Weh, Katherine, Howard, Connor, Lagisetty, Kiran, McEwen, Dyke, Lin, Jules, Reddy, Rishindra M., Chang, Andrew, Beer, David G., Howell, Amy, Kresty, Laura A.

“…Esophageal adenocarcinoma (EAC) is a devastating cancer characterized by rising incidence and poor prognosis. The five-year survival rate is 20% due to late…”
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Abstract PR001: Mechanisms by which Mito-LND inhibits KRAS mutant lung cancer by Weh, Katherine M., Howard, Connor L., Zhang, Yun, Riethoven, Jean-Jack, Clarke, Jennifer L., Kalyanaraman, Balaraman, You, Ming, Kresty, Laura A.

“…Lung cancer remains the most frequently diagnosed cancer and leading cause of cancer mortality in the United States and worldwide. Efficacious targeted options…”
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Abstract 5250: Cranberry proanthocyanidins reverse microbial dysbiosis and inhibit bile acid metabolism in association with esophageal cancer prevention by Weh, Katherine M., Salzman, Nita H., Howell, Amy B., Clarke, Jennifer L., Tripp, Bridget A., Kresty, Laura A.

“…Our laboratory has been investigating the cancer inhibitory potential of cranberry proanthocyanidins (C-PAC) against esophageal adenocarcinoma (EAC), a cancer…”
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Abstract 279: Cranberry proanthocyanidins mitigate reflux-induced transporter dysregulation in esophageal adenocarcinoma by Weh, Katherine M., Tripp, Bridget A., Clarke, Jennifer L., Howell, Amy B., Lin, Jules, Beer, David G., Chang, Andrew C., Kresty, Laura A.

“…Esophageal adenocarcinoma (EAC) incidence rates have increased sharply (>500%) throughout the Westernized world since the 1980s, despite the widespread use of…”
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