Search Results - "Wegener, Jörg W"

L-type CaV1.2 calcium channels: from in vitro findings to in vivo function by Hofmann, Franz, Flockerzi, Veit, Kahl, Sabine, Wegener, Jörg W

“…The L-type Cav1.2 calcium channel is present throughout the animal kingdom and is essential for some aspects of CNS function, cardiac and smooth muscle…”
Get full text

1,4-Benzothiazepines with Cyclopropanol Groups and Their Structural Analogues Exhibit Both RyR2-Stabilizing and SERCA2a-Stimulating Activities by Mitronova, Gyuzel Y., Quentin, Christine, Belov, Vladimir N., Wegener, Jörg W., Kiszka, Kamila A., Lehnart, Stephan E.

“…To discover new multifunctional agents for the treatment of cardiovascular diseases, we designed and synthesized a series of compounds with a cyclopropyl…”
Get full text

A junctional cAMP compartment regulates rapid Ca2+ signaling in atrial myocytes by Brandenburg, Sören, Pawlowitz, Jan, Steckmeister, Vanessa, Subramanian, Hariharan, Uhlenkamp, Dennis, Scardigli, Marina, Mushtaq, Mufassra, Amlaz, Saskia I., Kohl, Tobias, Wegener, Jörg W., Arvanitis, Demetrios A., Sanoudou, Despina, Sacconi, Leonardo, Hasenfuß, Gerd, Voigt, Niels, Nikolaev, Viacheslav O., Lehnart, Stephan E.

“…Axial tubule junctions with the sarcoplasmic reticulum control the rapid intracellular Ca2+-induced Ca2+ release that initiates atrial contraction. In atrial…”
Get full text

Dominant role of smooth muscle L-type calcium channel Cav1.2 for blood pressure regulation by Moosmang, Sven, Schulla, Verena, Welling, Andrea, Feil, Robert, Feil, Susanne, Wegener, Jörg W., Hofmann, Franz, Klugbauer, Norbert

“…Blood pressure is regulated by a number of key molecules involving G‐protein‐coupled receptors, ion channels and monomeric small G‐proteins. The relative…”
Get full text

Rescue of cGMP Kinase I Knockout Mice by Smooth Muscle–Specific Expression of Either Isozyme by Weber, Silke, Bernhard, Dominik, Lukowski, Robert, Weinmeister, Pascal, Wörner, René, Wegener, Jörg W, Valtcheva, Nadejda, Feil, Susanne, Schlossmann, Jens, Hofmann, Franz, Feil, Robert

“…Smooth muscle expresses the Iα and the Iβ isoforms of cGMP-dependent protein kinase I (cGKI). Inactivation of the murine cGKI gene prkg1 leads to multiple…”
Get full text

The RyR2-R2474S Mutation Sensitizes Cardiomyocytes and Hearts to Catecholaminergic Stress-Induced Oxidation of the Mitochondrial Glutathione Pool by Wegener, Jörg W, Wagdi, Ahmed, Wagner, Eva, Katschinski, Dörthe M, Hasenfuss, Gerd, Bruegmann, Tobias, Lehnart, Stephan E

“…Missense mutations in the cardiac ryanodine receptor type 2 (RyR2) characteristically cause catecholaminergic arrhythmias. Reminiscent of the phenotype in…”
Get full text

cGMP-Dependent Protein Kinase I Mediates the Negative Inotropic Effect of cGMP in the Murine Myocardium by Wegener, Jörg W, Nawrath, Hermann, Wolfsgruber, Wiebke, Kühbandner, Susanne, Werner, Claudia, Hofmann, Franz, Feil, Robert

“…To study the role of cGMP-dependent protein kinase I (cGKI) for cardiac contractility, force of contraction (Fc) was studied in electrically driven heart…”
Get full text

Tetra-acetylajugasterone a new constituent of Vitex cienkowskii with vasorelaxant activity by Dongmo, Alain Bertrand, Nkeng-Efouet, Pepin Alango, Devkota, Krishna Prasad, Wegener, Jörg W., Sewald, Norbert, Wagner, Hildebert, Vierling, Wolfgang

“…Tetra-acetylajugasterone C (TAAC) was found to be one of the naturally occurring compounds of the Cameroonian medicinal plant Vitex cienkowskii which is…”
Get full text

Control of intestinal motility by the Cav1.2 L-type calcium channel in mice by Wegener, Jörg W, Schulla, Verena, Koller, Angela, Klugbauer, Norbert, Feil, Robert, Hofmann, Franz

“…The Cav1.2 L-type Ca²⁺ channel is the dominant voltage-activated Ca²⁺ channel in heart and smooth muscle. The functional significance of this channel was…”
Get full text

IRAG determines nitric oxide- and atrial natriuretic peptide-mediated smooth muscle relaxation by Desch, Matthias, Sigl, Katja, Hieke, Bernhard, Salb, Katharina, Kees, Frieder, Bernhard, Dominik, Jochim, Angela, Spiessberger, Beate, Höcherl, Klaus, Feil, Robert, Feil, Susanne, Lukowski, Robert, Wegener, Jörg W., Hofmann, Franz, Schlossmann, Jens

“…Aims Nitric oxide (NO) and atrial natriuretic peptide (ANP) signalling via cGMP controls smooth muscle tone. One important signalling pathway of cGMP-dependent…”
Get full text

An essential role of Cav1.2 L‐type calcium channel for urinary bladder function by Wegener, Jörg W., Schulla, Verena, Lee, Tae‐Seong, Koller, Angela, Feil, Susanne, Feil, Robert, Kleppisch, Thomas, Klugbauer, Norbert, Moosmang, Sven, Welling, Andrea, Hofmann, Franz

“…ABSTRACT Mice deficient in the smooth muscle Cav1.2 calcium channel (SMACKO, smooth muscle α1c‐ subunit calcium channel knockout) have a severely reduced…”
Get full text

cGMP signals mainly through cAMP kinase in permeabilized murine aorta by Wörner, René, Lukowski, Robert, Hofmann, Franz, Wegener, Jörg W

“…GMP affects vascular tone by multiple mechanisms, including inhibition of the Rho/Rho kinase-mediated Ca(2+) sensitization, a process identified as Ca(2+)…”
Get more information

Severe Intestinal Obstruction on Induced Smooth Muscle–Specific Ablation of the Transcription Factor SRF in Adult Mice by Angstenberger, Meike, Wegener, Jörg W, Pichler, Bernd J, Judenhofer, Martin S, Feil, Susanne, Alberti, Siegfried, Feil, Robert, Nordheim, Alfred

“…Background & Aims: SRF ( S erum R esponse F actor), a widely expressed transcription factor, controls expression of mitogen-responsive and muscle-specific…”
Get full text

Noninvasive analysis of contractility during identical maturations revealed two phenotypes in ventricular but not in atrial iPSC-CM by Rapöhn, Marcel, Cyganek, Lukas, Voigt, Niels, Hasenfuß, Gerd, Lehnart, Stephan E, Wegener, Jörg W

“…Patient-derived induced pluripotent stem cells (iPSCs) can be differentiated into atrial and ventricular cardiomyocytes to allow for personalized drug…”
Get more information

Truncation of Murine Cav1.2 at Asp-1904 Results in Heart Failure after Birth by Domes, Katrin, Ding, Jie, Lemke, Toni, Blaich, Anne, Wegener, Jörg W., Brandmayr, Julia, Moosmang, Sven, Hofmann, Franz

“…The carboxyl-terminal intracellular tail of the l-type Ca2+ channel CaV1.2 modulates various aspects of channel activity. For example, deletion of the…”
Get full text

cAMP Imaging at Ryanodine Receptors Reveals β2-Adrenoceptor Driven Arrhythmias by Berisha, Filip, Götz, Konrad R., Wegener, Jörg W., Brandenburg, Sören, Subramanian, Hariharan, Molina, Cristina E., Rüffer, André, Petersen, Johannes, Bernhardt, Alexander, Girdauskas, Evaldas, Jungen, Christiane, Pape, Ulrike, Kraft, Axel E., Warnke, Svenja, Lindner, Diana, Westermann, Dirk, Blankenberg, Stefan, Meyer, Christian, Hasenfuß, Gerd, Lehnart, Stephan E., Nikolaev, Viacheslav O.

“…3',5'-cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger which, upon β-adrenergic receptor (β-AR) stimulation, acts in microdomains to…”
Get full text

cGMP-dependent protein kinases (cGK) by Hofmann, Franz, Wegener, Jörg W

“…cGMP-dependent protein kinases (cGK) are serine/threonine kinases that are widely distributed in eukaryotes. Two genes-prkg1 and prkg2-code for cGKs, namely,…”
Get more information

The role of cGMP/cGKI signalling and Trpc channels in regulation of vascular tone by Loga, Florian, Domes, Katrin, Freichel, Marc, Flockerzi, Veit, Dietrich, Alexander, Birnbaumer, Lutz, Hofmann, Franz, Wegener, Jörg W

“…Signalling via cGMP-dependent protein kinase I (cGKI) is the major pathway in vascular smooth muscle (SM), by which endothelial NO regulates vascular tone…”
Get full text

Murine cardiac growth, TRPC channels, and cGMP kinase I by Domes, Katrin, Patrucco, Enrico, Loga, Florian, Dietrich, Alexander, Birnbaumer, Lutz, Wegener, Jörg W., Hofmann, Franz

“…Signaling via cGMP-dependent protein kinase I (cGKI) and canonical transient receptor potential (TRPC) channels appears to be involved in the regulation of…”
Get full text

Phospholipase D1 is involved in α1-adrenergic contraction of murine vascular smooth muscle by Wegener, Jörg W, Loga, Florian, Stegner, David, Nieswandt, Bernhard, Hofmann, Franz

“…α1-Adrenergic stimulation increases blood vessel tone in mammals. This process involves a number of intracellular signaling pathways that include signaling via…”
Get full text