Search Results - "Weersma, RK"

Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci by Folseraas, Trine, Melum, Espen, Rausch, Philipp, Juran, Brian D, Ellinghaus, Eva, Shiryaev, Alexey, Laerdahl, Jon K, Ellinghaus, David, Schramm, Christoph, Weismüller, Tobias J, Gotthardt, Daniel Nils, Hov, Johannes Roksund, Clausen, Ole Petter, Weersma, Rinse K, Janse, Marcel, Boberg, Kirsten Muri, Björnsson, Einar, Marschall, Hanns-Ulrich, Cleynen, Isabelle, Rosenstiel, Philip, Holm, Kristian, Teufel, Andreas, Rust, Christian, Gieger, Christian, Wichmann, H-Erich, Bergquist, Annika, Ryu, Euijung, Ponsioen, Cyriel Y, Runz, Heiko, Sterneck, Martina, Vermeire, Severine, Beuers, Ulrich, Wijmenga, Cisca, Schrumpf, Erik, Manns, Michael P, Lazaridis, Konstantinos N, Schreiber, Stefan, Baines, John F, Franke, Andre, Karlsen, Tom H

“…Background & Aims A limited number of genetic risk factors have been reported in primary sclerosing cholangitis (PSC). To discover further genetic…”
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Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci by Ellinghaus, David, Jostins, Luke, Spain, Sarah L, Cortes, Adrian, Bethune, Jörn, Han, Buhm, Park, Yu Rang, Raychaudhuri, Soumya, Pouget, Jennie G, Hübenthal, Matthias, Folseraas, Trine, Wang, Yunpeng, Esko, Tonu, Metspalu, Andres, Westra, Harm-Jan, Franke, Lude, Pers, Tune H, Weersma, Rinse K, Collij, Valerie, D'Amato, Mauro, Halfvarson, Jonas, Jensen, Anders Boeck, Lieb, Wolfgang, Degenhardt, Franziska, Forstner, Andreas J, Hofmann, Andrea, Schreiber, Stefan, Mrowietz, Ulrich, Juran, Brian D, Lazaridis, Konstantinos N, Brunak, Søren, Dale, Anders M, Trembath, Richard C, Weidinger, Stephan, Weichenthal, Michael, Ellinghaus, Eva, Elder, James T, Barker, Jonathan N W N, Andreassen, Ole A, McGovern, Dermot P, Karlsen, Tom H, Barrett, Jeffrey C, Parkes, Miles, Brown, Matthew A, Franke, Andre

“…David Ellinghaus and colleagues report a combined association analysis of five chronic inflammatory diseases. They identify 27 new associations and highlight…”
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Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations by Liu, Jimmy Z, van Sommeren, Suzanne, Huang, Hailiang, Ng, Siew C, Alberts, Rudi, Takahashi, Atsushi, Ripke, Stephan, Lee, James C, Jostins, Luke, Shah, Tejas, Abedian, Shifteh, Cheon, Jae Hee, Cho, Judy, Daryani, Naser E, Franke, Lude, Fuyuno, Yuta, Hart, Ailsa, Juyal, Ramesh C, Juyal, Garima, Kim, Won Ho, Morris, Andrew P, Poustchi, Hossein, Newman, William G, Midha, Vandana, Orchard, Timothy R, Vahedi, Homayon, Sood, Ajit, Sung, Joseph J Y, Malekzadeh, Reza, Westra, Harm-Jan, Yamazaki, Keiko, Yang, Suk-Kyun, Barrett, Jeffrey C, Franke, Andre, Alizadeh, Behrooz Z, Parkes, Miles, B K, Thelma, Daly, Mark J, Kubo, Michiaki, Anderson, Carl A, Weersma, Rinse K

“…Rinse Weersma, Carl Anderson and colleagues report the results of a trans-ancestry association study of inflammatory bowel disease. They implicate 38 new…”
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Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease by Ji, Sun-Gou, Juran, Brian D, Mucha, Sören, Folseraas, Trine, Jostins, Luke, Melum, Espen, Kumasaka, Natsuhiko, Atkinson, Elizabeth J, Schlicht, Erik M, Liu, Jimmy Z, Shah, Tejas, Gutierrez-Achury, Javier, Boberg, Kirsten M, Bergquist, Annika, Vermeire, Severine, Eksteen, Bertus, Durie, Peter R, Farkkila, Martti, Müller, Tobias, Schramm, Christoph, Sterneck, Martina, Weismüller, Tobias J, Gotthardt, Daniel N, Ellinghaus, David, Braun, Felix, Teufel, Andreas, Laudes, Mattias, Lieb, Wolfgang, Jacobs, Gunnar, Beuers, Ulrich, Weersma, Rinse K, Wijmenga, Cisca, Marschall, Hanns-Ulrich, Milkiewicz, Piotr, Pares, Albert, Kontula, Kimmo, Chazouillères, Olivier, Invernizzi, Pietro, Goode, Elizabeth, Spiess, Kelly, Moore, Carmel, Sambrook, Jennifer, Ouwehand, Willem H, Roberts, David J, Danesh, John, Floreani, Annarosa, Gulamhusein, Aliya F, Eaton, John E, Schreiber, Stefan, Coltescu, Catalina, Bowlus, Christopher L, Luketic, Velimir A, Odin, Joseph A, Chopra, Kapil B, Kowdley, Kris V, Chalasani, Naga, Manns, Michael P, Srivastava, Brijesh, Mells, George, Sandford, Richard N, Alexander, Graeme, Gaffney, Daniel J, Chapman, Roger W, Hirschfield, Gideon M, de Andrade, Mariza, Rushbrook, Simon M, Franke, Andre, Karlsen, Tom H, Lazaridis, Konstantinos N, Anderson, Carl A

“…Konstantinos Lazaridis, Carl Anderson and colleagues report results of a genome-wide association study of primary sclerosing cholangitis (PSC). They identify…”
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Population‐based epidemiology, malignancy risk, and outcome of primary sclerosing cholangitis by Boonstra, Kirsten, Weersma, Rinse K., Erpecum, Karel J., Rauws, Erik A., Spanier, B.W. Marcel, Poen, Alexander C., Nieuwkerk, Karin M., Drenth, Joost P., Witteman, Ben J., Tuynman, Hans A., Naber, Anton H., Kingma, Paul J., Buuren, Henk R., Hoek, Bart, Vleggaar, Frank P., Geloven, Nan, Beuers, Ulrich, Ponsioen, Cyriel Y.

“…Extensive population‐based studies are much needed to accurately establish epidemiology and disease course in patients with primary sclerosing cholangitis…”
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Analysis of 1135 gut metagenomes identifies sex-specific resistome profiles by Sinha, Trishla, Vich Vila, Arnau, Garmaeva, Sanzhima, Jankipersadsing, Soesma A., Imhann, Floris, Collij, Valerie, Bonder, Marc Jan, Jiang, Xiaofang, Gurry, Thomas, Alm, Eric J., D'Amato, Mauro, Weersma, Rinse K., Scherjon, Sicco, Wijmenga, Cisca, Fu, Jingyuan, Kurilshikov, Alexander, Zhernakova, Alexandra

“…Several gastrointestinal diseases show a sex imbalance, although the underlying (patho)physiological mechanisms behind this are not well understood. The gut…”
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HLA-DQA1–HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants by Heap, Graham A, Weedon, Michael N, Bewshea, Claire M, Singh, Abhey, Chen, Mian, Satchwell, Jack B, Vivian, Julian P, So, Kenji, Dubois, Patrick C, Andrews, Jane M, Annese, Vito, Bampton, Peter, Barnardo, Martin, Bell, Sally, Cole, Andy, Connor, Susan J, Creed, Tom, Cummings, Fraser R, D'Amato, Mauro, Daneshmend, Tawfique K, Fedorak, Richard N, Florin, Timothy H, Gaya, Daniel R, Greig, Emma, Halfvarson, Jonas, Hart, Alisa, Irving, Peter M, Jones, Gareth, Karban, Amir, Lawrance, Ian C, Lee, James C, Lees, Charlie, Lev-Tzion, Raffi, Lindsay, James O, Mansfield, John, Mawdsley, Joel, Mazhar, Zia, Parkes, Miles, Parnell, Kirstie, Orchard, Timothy R, Radford-Smith, Graham, Russell, Richard K, Reffitt, David, Satsangi, Jack, Silverberg, Mark S, Sturniolo, Giacomo C, Tremelling, Mark, Tsianos, Epameinondas V, van Heel, David A, Walsh, Alissa, Watermeyer, Gill, Weersma, Rinse K, Zeissig, Sebastian, Rossjohn, Jamie, Holden, Arthur L, Ahmad, Tariq

“…Graham Heap, Tariq Ahmad and colleagues show that common variants in the HLA-DQA1–HLA-DRB1 region confer susceptibility to thiopurine-induced pancreatitis in…”
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Genome‐wide association analysis in Primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4 by Ellinghaus, David, Folseraas, Trine, Holm, Kristian, Ellinghaus, Eva, Melum, Espen, Balschun, Tobias, Laerdahl, Jon K., Shiryaev, Alexey, Gotthardt, Daniel N., Weismüller, Tobias J., Schramm, Christoph, Wittig, Michael, Bergquist, Annika, Björnsson, Einar, Marschall, Hanns‐Ulrich, Vatn, Morten, Teufel, Andreas, Rust, Christian, Gieger, Christian, Wichmann, H‐Erich, Runz, Heiko, Sterneck, Martina, Rupp, Christian, Braun, Felix, Weersma, Rinse K., Wijmenga, Cisca, Ponsioen, Cyriel Y., Mathew, Christopher G., Rutgeerts, Paul, Vermeire, Séverine, Schrumpf, Erik, Hov, Johannes R., Manns, Michael P., Boberg, Kirsten M., Schreiber, Stefan, Franke, Andre, Karlsen, Tom H.

“…Approximately 60%‐80% of patients with primary sclerosing cholangitis (PSC) have concurrent ulcerative colitis (UC). Previous genome‐wide association studies…”
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Genome-Wide Association Analysis in Primary Sclerosing Cholangitis by Karlsen, Tom H, Franke, Andre, Melum, Espen, Kaser, Arthur, Hov, Johannes Roksund, Balschun, Tobias, Lie, Benedicte A, Bergquist, Annika, Schramm, Christoph, Weismüller, Tobias J, Gotthardt, Daniel, Rust, Christian, Philipp, Eva E.R, Fritz, Teresa, Henckaerts, Liesbet, Weersma, Rinse K, Stokkers, Pieter, Ponsioen, Cyriel Y, Wijmenga, Cisca, Sterneck, Martina, Nothnagel, Michael, Hampe, Jochen, Teufel, Andreas, Runz, Heiko, Rosenstiel, Philip, Stiehl, Adolf, Vermeire, Severine, Beuers, Ulrich, Manns, Michael P, Schrumpf, Erik, Boberg, Kirsten Muri, Schreiber, Stefan

“…Background & Aims We aimed to characterize the genetic susceptibility to primary sclerosing cholangitis (PSC) by means of a genome-wide association analysis of…”
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Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci by Karlsen, Tom H, Melum, Espen, Franke, Andre, Schramm, Christoph, Weismüller, Tobias J, Gotthardt, Daniel Nils, Offner, Felix A, Juran, Brian D, Laerdahl, Jon K, Labi, Verena, Björnsson, Einar, Weersma, Rinse K, Henckaerts, Liesbet, Teufel, Andreas, Rust, Christian, Ellinghaus, Eva, Balschun, Tobias, Boberg, Kirsten Muri, Ellinghaus, David, Bergquist, Annika, Sauer, Peter, Ryu, Euijung, Hov, Johannes Roksund, Wedemeyer, Jochen, Lindkvist, Björn, Wittig, Michael, Porte, Robert J, Holm, Kristian, Gieger, Christian, Wichmann, H-Erich, Stokkers, Pieter, Ponsioen, Cyriel Y, Runz, Heiko, Stiehl, Adolf, Wijmenga, Cisca, Sterneck, Martina, Vermeire, Severine, Beuers, Ulrich, Villunger, Andreas, Schrumpf, Erik, Lazaridis, Konstantinos N, Manns, Michael P, Schreiber, Stefan

“…Primary sclerosing cholangitis (PSC) is a chronic bile duct disease affecting 2.4-7.5% of individuals with inflammatory bowel disease. We performed a…”
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Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis by Alberts, Rudi, de Vries, Elisabeth M G, Goode, Elizabeth C, Jiang, Xiaojun, Sampaziotis, Fotis, Rombouts, Krista, Böttcher, Katrin, Folseraas, Trine, Weismüller, Tobias J, Mason, Andrew L, Wang, Weiwei, Alexander, Graeme, Alvaro, Domenico, Bergquist, Annika, Björkström, Niklas K, Beuers, Ulrich, Björnsson, Einar, Boberg, Kirsten Muri, Bowlus, Christopher L, Bragazzi, Maria C, Carbone, Marco, Chazouillères, Olivier, Cheung, Angela, Dalekos, Georgios, Eaton, John, Eksteen, Bertus, Ellinghaus, David, Färkkilä, Martti, Festen, Eleonora A M, Floreani, Annarosa, Franceschet, Irene, Gotthardt, Daniel Nils, Hirschfield, Gideon M, Hoek, Bart van, Holm, Kristian, Hohenester, Simon, Hov, Johannes Roksund, Imhann, Floris, Invernizzi, Pietro, Juran, Brian D, Lenzen, Henrike, Lieb, Wolfgang, Liu, Jimmy Z, Marschall, Hanns-Ulrich, Marzioni, Marco, Melum, Espen, Milkiewicz, Piotr, Müller, Tobias, Pares, Albert, Rupp, Christian, Rust, Christian, Sandford, Richard N, Schramm, Christoph, Schreiber, Stefan, Schrumpf, Erik, Silverberg, Mark S, Srivastava, Brijesh, Sterneck, Martina, Teufel, Andreas, Vallier, Ludovic, Verheij, Joanne, Vila, Arnau Vich, Vries, Boudewijn de, Zachou, Kalliopi, Chapman, Roger W, Manns, Michael P, Pinzani, Massimo, Rushbrook, Simon M, Lazaridis, Konstantinos N, Franke, Andre, Anderson, Carl A, Karlsen, Tom H, Ponsioen, Cyriel Y, Weersma, Rinse K

“…Primary sclerosing cholangitis (PSC) is a genetically complex, inflammatory bile duct disease of largely unknown aetiology often leading to liver…”
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Multiomics Analyses to Deliver the Most Effective Treatment to Every Patient With Inflammatory Bowel Disease by Weersma, Rinse K., Xavier, Ramnik J., Weersma, R.K., Barrett, J.C., Vermeire, S., Xavier, R.J., Anderson, C.A., Wijmenga, C., Daly, M.J., Alm, E.J., Raes, J., Huttenhower, C., Stappenbeck, T., Netea, M., Kaser, A., Franke, A., McGovern, D.P., Colombel, J.F., van den Brink, G.R., Uhlig, H.H., Georges, M., Lees, C.W., Parkes, M., Giallourakis, C., Hart, A., Rioux, J.D., Sokol, H., Hurtado-Lorenzo, A., Yeretssian, G., Markus- de Kwaadsteniet, M.L., Festen, E.A., Rahmouni, S., Vieira-Silva, S., McIntyre, R.E., Moutsianas, L., Vermeire, Severine, Barrett, Jeffrey C.

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Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9 by Janse, Marcel, Lamberts, Laetitia E., Franke, Lude, Raychaudhuri, Soumya, Ellinghaus, Eva, Muri Boberg, Kirsten, Melum, Espen, Folseraas, Trine, Schrumpf, Erik, Bergquist, Annika, Björnsson, Einar, Fu, Jingyuan, Jan Westra, Harm, Groen, Harry J.M., Fehrmann, Rudolf S.N., Smolonska, Joanna, van den Berg, Leonard H., Ophoff, Roel A., Porte, Robert J., Weismüller, Tobias J., Wedemeyer, Jochen, Schramm, Christoph, Sterneck, Martina, Günther, Rainer, Braun, Felix, Vermeire, Severine, Henckaerts, Liesbet, Wijmenga, Cisca, Ponsioen, Cyriel Y., Schreiber, Stefan, Karlsen, Tom H., Franke, Andre, Weersma, Rinse K.

“…Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by inflammation and fibrosis of the bile ducts. Both environmental…”
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Human Leukocyte Antigen Signatures as Pathophysiological Discriminants of Microscopic Colitis Subtypes by Zheng, Tenghao, Roda, Giulia, Zabana, Yamile, Escudero-Hernández, Celia, Liu, Xingrong, Chen, Ye, Camargo Tavares, Leticia, Bonfiglio, Ferdinando, Mellander, Marie-Rose, Janczewska, Izabella, Vigren, Lina, Sjöberg, Klas, Ohlsson, Bodil, Almer, Sven, Halfvarson, Jonas, Miehlke, Stephan, Madisch, Ahmed, Lieb, Wolfgang, Kupčinskas, Juozas, Weersma, Rinse K, Bujanda, Luis, Julià, Antonio, Marsal, Sara, Esteve, Maria, Guagnozzi, Danila, Fernández-Bañares, Fernando, Ferrer, Carmen, Peter, Inga, Ludvigsson, Jonas F, Pardi, Darrell, Verhaegh, Bas, Jonkers, Daisy, Pierik, Marieke, Münch, Andreas, Franke, Andre, Bresso, Francesca, Khalili, Hamed, Colombel, Jean-Frederic, D'Amato, Mauro

“…Microscopic colitis [MC] is currently regarded as an inflammatory bowel disease that manifests as two subtypes: collagenous colitis [CC] and lymphocytic…”
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Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis by Hov, Johannes R, Keitel, Verena, Laerdahl, Jon K, Spomer, Lina, Ellinghaus, Eva, ElSharawy, Abdou, Melum, Espen, Boberg, Kirsten M, Manke, Thomas, Balschun, Tobias, Schramm, Christoph, Bergquist, Annika, Weismüller, Tobias, Gotthardt, Daniel, Rust, Christian, Henckaerts, Liesbet, Onnie, Clive M, Weersma, Rinse K, Sterneck, Martina, Teufel, Andreas, Runz, Heiko, Stiehl, Adolf, Ponsioen, Cyriel Y, Wijmenga, Cisca, Vatn, Morten H, Stokkers, Pieter C F, Vermeire, Severine, Mathew, Christopher G, Lie, Benedicte A, Beuers, Ulrich, Manns, Michael P, Schreiber, Stefan, Schrumpf, Erik, Häussinger, Dieter, Franke, Andre, Karlsen, Tom H

“…TGR5, the G protein-coupled bile acid receptor 1 (GPBAR1), has been linked to inflammatory pathways as well as bile homeostasis, and could therefore be…”
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HLA signatures as pathophysiological discriminants of microscopic colitis subtypes by Zheng, T, Roda, G, Zabana, Y, Escudero-Hernández, C, Liu, X, Chen, Y, Camargo Tavares, L, Bonfiglio, F, Mellander, MR, Janczewska, I, Vigren, L, Sjöberg, K, Ohlsson, B, Almer, S, Halfvarson, J, Miehlke, S, Madisch, A, Lieb, W, Kupčinskas, J, Weersma, RK, Bujanda, L, Julià, A, Marsal, S, Esteve, M, Guagnozzi, D, Fernández-Bañares, F, Ferrer, C, Peter, I, Ludvigsson, JF, Pardi, D, Verhaegh, B, Jonkers, D, Pierik, M, Münch, A, Franke, A, Bresso, F, Khalili, H, Colombel, JF, D'Amato, M

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How will insights from genetics translate to clinical practice in inflammatory bowel disease? by Festen, E.A.M., MD, PhD, Weersma, R.K., MD, PhD

“…Abstract Inflammatory bowel disease, consisting of Crohn's disease and ulcerative colitis, is a chronic inflammatory disease of the gut, which arises through…”
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Immune-mediated diseases in primary sclerosing cholangitis by Lamberts, Laetitia E, Janse, Marcel, Haagsma, Elizabeth B, van den Berg, Arie P, Weersma, Rinse K

“…Abstract Background Primary sclerosing cholangitis is a chronic cholestatic liver disease. An immune aetiology is suggested by associations between PSC and…”
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Genotype-Phenotype Analysis across 130,422 Genetic Variants Identifies Rspo3 as the First Genome-Wide Significant Modifier Gene in Primary Sclerosing Cholangitis by Alberts, R, de Vries, E.M, Alexander, G, Alvaro, D, Bergquist, A, Beuers, U, Björnsson, E, Boberg, K.M, Bowlus, C.L, Chapman, R.W, Chazouilléres, O, Cheung, A, Dalekos, G, Eksteen, B, Eaton, J.E, Ellinghaus, D, Färkkilä, M, Festen, E.A, Floreani, A, Folseraas, T, Goode, E, Gotthardt, D.N, Hirschfield, G.M, van Hoek, B, Hohenester, S, Holm, K, Hov, J.R, Imhann, F, Invernizzi, P, Jiang, X, Juran, B.D, Lazaridis, K.N, Leppa, V, Liu, J.Z, Löfberg, J, Manns, M.P, Marschall, H.-U, Marzioni, M, Mason, A.L, Melum, E, Müller, T, Milkiewicz, P, Pares, A, Pelkonen, V, Pinzani, M, Rombouts, K, Rupp, C, Rushbrook, S.M, Rust, C, Sampaziotis, F, Sandford, R.N, Schramm, C, Schreiber, S, Schrumpf, E, Silverberg, M, Srivastava, B, Sterneck, M, Teufel, A, Tittmann, L, Vallier, L, Vila, A.V, de Vries, B.A, Weismüller, T.J, Wijmenga, C, Zachou, K, Franke, A, Anderson, C.A, Karlsen, T.H, Ponsioen, C.Y, Weersma, K

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Increased incidence of azathioprine‐induced pancreatitis in Crohn's disease compared with other diseases by Weersma, R. K., Peters, F. T. M., Oostenbrug, L. E., Berg, A. P., Haastert, M., Ploeg, R. J., Posthumus, M. D., Homan van der Heide, J. J., Jansen, P. L. M., Dullemen, H. M.

“…Summary Background : Azathioprine is widely used in Crohn's disease. A major drawback is the occurrence of side‐effects, especially acute pancreatitis. Acute…”
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