Search Results - "Weers, Jeffry G"

Spray-Dried PulmoSphere™ Formulations for Inhalation Comprising Crystalline Drug Particles by Weers, Jeffry G., Miller, Danforth P., Tarara, Thomas E.

“…Over the past 20 years, solution-based spray dried powders have transformed inhaled product development, enabling aerosol delivery of a wider variety of…”
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Optimizing Spray-Dried Porous Particles for High Dose Delivery with a Portable Dry Powder Inhaler by Son, Yoen-Ju, Miller, Danforth P., Weers, Jeffry G.

“…This manuscript critically reviews the design and delivery of spray-dried particles for the achievement of high total lung doses (TLD) with a portable dry…”
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Targeting of Inhaled Therapeutics to the Small Airways: Nanoleucine Carrier Formulations by Miller, Danforth P., Tarara, Thomas E., Weers, Jeffry G.

“…Current dry powder formulations for inhalation deposit a large fraction of their emitted dose in the upper respiratory tract where they contribute to…”
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The Confusing World of Dry Powder Inhalers: It Is All About Inspiratory Pressures, Not Inspiratory Flow Rates by Clark, Andrew R, Weers, Jeffry G, Dhand, Rajiv

“…Dry powder inhalers (DPIs) all have the ability to aerosolize dry powders, but they each offer different operating mechanisms and resistances to inhaled…”
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Formulation Design of Dry Powders for Inhalation by Weers, Jeffry G, Miller, Danforth P

“…Drugs for inhalation are no longer exclusively highly crystalline small molecules. They may also be amorphous small molecules, peptides, antibodies, and myriad…”
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Inhalation of a dry powder tobramycin PulmoSphere formulation in healthy volunteers by Newhouse, Michael T, Hirst, Peter H, Duddu, Sarma P, Walter, Yulia H, Tarara, Thomas E, Clark, Andrew R, Weers, Jeffry G

“…To evaluate the efficiency and reproducibility of pulmonary delivery of an investigational tobramycin PulmoSphere formulation (PStob) [Inhale Therapeutic…”
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Post-inhalation cough with therapeutic aerosols: Formulation considerations by Sahakijpijarn, Sawittree, Smyth, Hugh D.C., Miller, Danforth P., Weers, Jeffry G.

“…This review provides an assessment of post-inhalation cough with therapeutic aerosols. Factors that increase cough may be mitigated through design of the drug,…”
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Characterization of suspension-based metered dose inhaler formulations composed of spray-dried budesonide microcrystals dispersed in HFA-134a by Tarara, Thomas E, Hartman, Michael S, Gill, Howard, Kennedy, Alan A, Weers, Jeffry G

“…To assess the physicochemical characteristics and aerosol properties of suspensions of lipid-coated budesonide microcrystals dispersed in HFA-134a…”
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Ciprofloxacin Dry Powder for Inhalation (ciprofloxacin DPI): Technical design and features of an efficient drug–device combination by McShane, Pamela J., Weers, Jeffry G., Tarara, Thomas E., Haynes, Alfred, Durbha, Preeti, Miller, Danforth P., Mundry, Tobias, Operschall, Elisabeth, Elborn, J. Stuart

“…Bronchiectasis is a chronic respiratory disease with heterogeneous etiology, characterized by a cycle of bacterial infection and inflammation, resulting in…”
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Physical Characterization of Tobramycin Inhalation Powder: I. Rational Design of a Stable Engineered-Particle Formulation for Delivery to the Lungs by Miller, Danforth P, Tan, Trixie, Tarara, Thomas E, Nakamura, John, Malcolmson, Richard J, Weers, Jeffry G

“…A spray-dried engineered particle formulation, Tobramycin Inhalation Powder (TIP), was designed through rational selection of formulation composition and…”
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Enhanced design of inhaled therapeutics: what does the future hold? by Weers, Jeffry G

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Design of spray dried insulin microparticles to bypass deposition in the extrathoracic region and maximize total lung dose by Ung, Keith T., Rao, Nagaraja, Weers, Jeffry G., Huang, Daniel, Chan, Hak-Kim

“…Micromeritic properties of the spray dried particles are important for lung targeting oral inhalation products. The high total lung dose for the protein…”
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Physical Characterization of Tobramycin Inhalation Powder: II. State Diagram of an Amorphous Engineered Particle Formulation by Miller, Danforth P, Tan, Trixie, Nakamura, John, Malcolmson, Richard J, Tarara, Thomas E, Weers, Jeffry G

“…Tobramycin Inhalation Powder (TIP) is a spray-dried engineered particle formulation used in TOBI Podhaler, a drug-device combination for treatment of cystic…”
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Idealhalers Versus Realhalers: Is It Possible to Bypass Deposition in the Upper Respiratory Tract? by Weers, Jeffry G, Son, Yoen-Ju, Glusker, Mark, Haynes, Alfred, Huang, Daniel, Kadrichu, Nani, Le, John, Li, Xue, Malcolmson, Richard, Miller, Danforth P, Tarara, Thomas E, Ung, Keith, Clark, Andy

“…This review discusses how advances in formulation and device design can be utilized to dramatically improve lung targeting and dose consistency relative to…”
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In Vitro Assessment of Dose Delivery Performance of Dry Powders for Inhalation by Ung, Keith T., Rao, Nagaraja, Weers, Jeffry G., Clark, Andrew R., Chan, Hak-Kim

“…The aerosol performance of engineered porous particles (PulmoSphere™) for inhalation as a function of powder properties (particle size and density) was…”
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In Vitro-In Vivo Correlations Observed With Indacaterol-Based Formulations Delivered with the Breezhaler by Weers, Jeffry G, Clark, Andrew R, Rao, Nagaraja, Ung, Keith, Haynes, Alfred, Khindri, Sanjeev K, Perry, Sheryl A, Machineni, Surendra, Colthorpe, Paul

“…Establishing robust in vitro-in vivo correlations (IVIVC) between aerosol performance, pharmacokinetics, and clinical efficacy is critical in developing…”
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Pulmonary formulations: what remains to be done? by Weers, Jeffry G, Bell, John, Chan, Hak-Kim, Cipolla, David, Dunbar, Craig, Hickey, Anthony J, Smith, Ian J

“…Significant advances have been made in the last 50 years in developing safe and efficacious aerosol formulations for pulmonary delivery. The key to future…”
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Design of fine particles for pulmonary drug delivery by Weers, Jeffry G, Tarara, Thomas E, Clark, Andrew R

“…Particle design for inhalation is characterized by advances in particle processing methods and the utilization of new excipients. Processing methods such as…”
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Inhaler devices: what remains to be done? by Smith, Ian J, Bell, John, Bowman, Nic, Everard, Mark, Stein, Stephen, Weers, Jeffry G

“…The 1000 Years of Pharmaceutical Aerosols Conference convened posing the question; "what remains to be done?" When applying this question to the topic of…”
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Effect of the intramolecular charge separation distance on the solution properties of betaines and sulfobetaines by Weers, Jeffry G, Rathman, James F, Axe, Frank U, Crichlow, Charles A, Foland, Lafayette D, Scheuing, David R, Wiersema, Richard J, Zielske, Alfred G

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