Search Results - "Weerasinghe, Sujith V.W."

The structural requirements of histone deacetylase inhibitors: Suberoylanilide hydroxamic acid analogs modified at the C3 position display isoform selectivity by Choi, Sun Ea, Weerasinghe, Sujith V.W., Pflum, Mary Kay H.

“…The FDA-approved drug suberoylanilide hydroxamic acid (SAHA, Vorinostat) was modified to improve its selectivity for a single histone deaetylase (HDAC)…”
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Keratin Hypersumoylation Alters Filament Dynamics and Is a Marker for Human Liver Disease and Keratin Mutation by Snider, Natasha T., Weerasinghe, Sujith V.W., Iñiguez-Lluhí, Jorge A., Herrmann, Harald, Omary, M. Bishr

“…Keratin polypeptide 8 (K8) associates noncovalently with its partners K18 and/or K19 to form the intermediate filament cytoskeleton of hepatocytes and other…”
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Energy determinants GAPDH and NDPK act as genetic modifiers for hepatocyte inclusion formation by Snider, Natasha T, Weerasinghe, Sujith V W, Singla, Amika, Leonard, Jessica M, Hanada, Shinichiro, Andrews, Philip C, Lok, Anna S, Omary, M Bishr

“…Genetic factors impact liver injury susceptibility and disease progression. Prominent histological features of some chronic human liver diseases are hepatocyte…”
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The Role of Carbamoyl Phosphate Synthetase 1 as a Prognostic Biomarker in Patients With Acetaminophen-induced Acute Liver Failure by Kwan, Raymond, Chen, Lu, Park, Min-Jung, Su, Zemin, Weerasinghe, Sujith V.W., Lee, William M., Durkalski-Mauldin, Valerie L., Fontana, Robert J., Omary, M Bishr

“…Carbamoyl phosphate synthetase 1 (CPS1) is a highly abundant mitochondrial urea cycle enzyme that is expressed primarily in hepatocytes. CPS1 is constitutively…”
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Carbamoyl phosphate synthetase-1 is a rapid turnover biomarker in mouse and human acute liver injury by Weerasinghe, Sujith V W, Jang, You-Jin, Fontana, Robert J, Omary, M Bishr

“…Several serum markers are used to assess hepatocyte damage, but they have limitations related to etiology specificity and prognostication. Identification of…”
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Mutation of caspase-digestion sites in keratin 18 interferes with filament reorganization, and predisposes to hepatocyte necrosis and loss of membrane integrity by Weerasinghe, Sujith V W, Ku, Nam-On, Altshuler, Peter J, Kwan, Raymond, Omary, M Bishr

“…Keratin 18 (K18 or KRT18) undergoes caspase-mediated cleavage during apoptosis, the significance of which is poorly understood. Here, we mutated the two…”
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Mouse genetic background contributes to hepatocyte susceptibility to Fas-mediated apoptosis by Weerasinghe, Sujith V W, Park, Min-Jung, Portney, Daniel A, Omary, M Bishr

“…Liver disease progression is modulated by genetic modifiers in mouse strains and across human races and ethnicities. We hypothesized that hepatocyte culture…”
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Residues in the 11 Å Channel of Histone Deacetylase 1 Promote Catalytic Activity: Implications for Designing Isoform-Selective Histone Deacetylase Inhibitors by Weerasinghe, Sujith V. W, Estiu, Guillermina, Wiest, Olaf, Pflum, Mary Kay H

“…Histone deacetylase 1 (HDAC1) has been linked to cell growth and cell cycle regulation, which makes it a widely recognized target for anticancer drugs. Whereas…”
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CD73 (ecto‐5′‐nucleotidase) hepatocyte levels differ across mouse strains and contribute to mallory‐denk body formation by Snider, Natasha T., Griggs, Nicholas W., Singla, Amika, Moons, David S., Weerasinghe, Sujith V.W., Lok, Anna S., Ruan, Chunhai, Burant, Charles F., Conjeevaram, Hari S., Omary, M. Bishr

“…Formation of hepatocyte Mallory‐Denk bodies (MDBs), which are aggregates of keratins 8 and 18 (K8/K18), ubiquitin, and the ubiquitin‐binding protein, p62, has…”
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Structural Requirements of Histone Deacetylase Inhibitors: SAHA Analogs Modified on the Hydroxamic Acid by Bieliauskas, Anton V., Weerasinghe, Sujith V. W., Negmeldin, Ahmed T., Pflum, Mary Kay H.

“…Histone deacetylase (HDAC) proteins have emerged as targets for anti‐cancer therapeutics, with several inhibitors used in the clinic, including suberoylanilide…”
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Fibrinogen‐γ proteolysis and solubility dynamics during apoptotic mouse liver injury: Heparin prevents and treats liver damage by Weerasinghe, Sujith V. W., Moons, David S., Altshuler, Peter J., Shah, Yatrik M., Omary, M. Bishr

“…Fas ligand (FasL)‐mediated hepatocyte apoptosis occurs in the context of acute liver injury that can be accompanied by intravascular coagulation (IC). We…”
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Structural requirements of HDAC inhibitors: SAHA analogs functionalized adjacent to the hydroxamic acid by Bieliauskas, Anton V., Weerasinghe, Sujith V.W., Pflum, Mary Kay H.

“…The synthesis and biological evaluation of a small library of C2-substituted SAHA analogs is reported. Inhibitors of histone deacetylase (HDAC) proteins such…”
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A histone deacetylase-dependent screen in yeast by Weerasinghe, Sujith V.W., Wambua, Magdalene, Pflum, Mary Kay H.

“…Histone deacetylase (HDAC) proteins are promising targets for cancer treatment, as shown by the recent FDA approval of the HDAC inhibitor suberoylanilide…”
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Synthesis and biological evaluation of histone deacetylase inhibitors that are based on FR235222: A cyclic tetrapeptide scaffold by Singh, Erinprit K., Ravula, Suchitra, Pan, Chung-Mao, Pan, Po-Shen, Vasko, Robert C., Lapera, Stephanie A., Weerasinghe, Sujith V.W., Pflum, Mary Kay H., McAlpine, Shelli R.

“…We outline the synthesis of six novel derivatives that are based on a recently discovered HDAC inhibitor FR235222. Our work is the first report utilizing a…”
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