Search Results - "Weekes, Michael P"

Quantitative temporal viromics: an approach to investigate host-pathogen interaction by Weekes, Michael P, Tomasec, Peter, Huttlin, Edward L, Fielding, Ceri A, Nusinow, David, Stanton, Richard J, Wang, Eddie C Y, Aicheler, Rebecca, Murrell, Isa, Wilkinson, Gavin W G, Lehner, Paul J, Gygi, Steven P

“…A systematic quantitative analysis of temporal changes in host and viral proteins throughout the course of a productive infection could provide dynamic…”
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NOTCH1 mediates a switch between two distinct secretomes during senescence by Hoare, Matthew, Ito, Yoko, Kang, Tae-Won, Weekes, Michael P., Matheson, Nicholas J., Patten, Daniel A., Shetty, Shishir, Parry, Aled J., Menon, Suraj, Salama, Rafik, Antrobus, Robin, Tomimatsu, Kosuke, Howat, William, Lehner, Paul J., Zender, Lars, Narita, Masashi

“…Senescence, a persistent form of cell-cycle arrest, is often associated with a diverse secretome, which provides complex functionality for senescent cells…”
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Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef by Matheson, Nicholas J., Sumner, Jonathan, Wals, Kim, Rapiteanu, Radu, Weekes, Michael P., Vigan, Raphael, Weinelt, Julia, Schindler, Michael, Antrobus, Robin, Costa, Ana S.H., Frezza, Christian, Clish, Clary B., Neil, Stuart J.D., Lehner, Paul J.

“…Critical cell surface immunoreceptors downregulated during HIV infection have previously been identified using non-systematic, candidate approaches. To gain a…”
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Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation by Wang, Liang Wei, Shen, Hongying, Nobre, Luis, Ersing, Ina, Paulo, Joao A., Trudeau, Stephen, Wang, Zhonghao, Smith, Nicholas A., Ma, Yijie, Reinstadler, Bryn, Nomburg, Jason, Sommermann, Thomas, Cahir-McFarland, Ellen, Gygi, Steven P., Mootha, Vamsi K., Weekes, Michael P., Gewurz, Benjamin E.

“…Epstein-Barr virus (EBV) causes Burkitt, Hodgkin, and post-transplant B cell lymphomas. How EBV remodels metabolic pathways to support rapid B cell outgrowth…”
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Epstein-Barr virus BNRF1 destabilizes SMC5/6 cohesin complexes to evade its restriction of replication compartments by Yiu, Stephanie Pei Tung, Guo, Rui, Zerbe, Cassie, Weekes, Michael P., Gewurz, Benjamin E.

“…Epstein-Barr virus (EBV) persistently infects people worldwide. Delivery of ∼170-kb EBV genomes to nuclei and use of nuclear membrane-less replication…”
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Epstein-Barr virus subverts mevalonate and fatty acid pathways to promote infected B-cell proliferation and survival by Wang, Liang Wei, Wang, Zhonghao, Ersing, Ina, Nobre, Luis, Guo, Rui, Jiang, Sizun, Trudeau, Stephen, Zhao, Bo, Weekes, Michael P, Gewurz, Benjamin E

“…Epstein-Barr virus (EBV) causes infectious mononucleosis and is associated with multiple human malignancies. EBV drives B-cell proliferation, which contributes…”
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Red blood cell tension protects against severe malaria in the Dantu blood group by Kariuki, Silvia N., Marin-Menendez, Alejandro, Introini, Viola, Ravenhill, Benjamin J., Lin, Yen-Chun, Macharia, Alex, Makale, Johnstone, Tendwa, Metrine, Nyamu, Wilfred, Kotar, Jurij, Carrasquilla, Manuela, Rowe, J. Alexandra, Rockett, Kirk, Kwiatkowski, Dominic, Weekes, Michael P., Cicuta, Pietro, Williams, Thomas N., Rayner, Julian C.

“…Malaria has had a major effect on the human genome, with many protective polymorphisms—such as the sickle-cell trait—having been selected to high frequencies…”
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Selective modulation of cell surface proteins during vaccinia infection: A resource for identifying viral immune evasion strategies by Depierreux, Delphine M., Altenburg, Arwen F., Soday, Lior, Fletcher-Etherington, Alice, Antrobus, Robin, Ferguson, Brian J., Weekes, Michael P., Smith, Geoffrey L.

“…The interaction between immune cells and virus-infected targets involves multiple plasma membrane (PM) proteins. A systematic study of PM protein modulation by…”
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A Mass Spectrometry-Based Approach for Mapping Protein Subcellular Localization Reveals the Spatial Proteome of Mouse Primary Neurons by Itzhak, Daniel N., Davies, Colin, Tyanova, Stefka, Mishra, Archana, Williamson, James, Antrobus, Robin, Cox, Jürgen, Weekes, Michael P., Borner, Georg H.H.

“…We previously developed a mass spectrometry-based method, dynamic organellar maps, for the determination of protein subcellular localization and identification…”
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The Proteasome Distinguishes between Heterotypic and Homotypic Lysine-11-Linked Polyubiquitin Chains by Grice, Guinevere L., Lobb, Ian T., Weekes, Michael P., Gygi, Steven P., Antrobus, Robin, Nathan, James A.

“…Proteasome-mediated degradation occurs with proteins principally modified with lysine-48 polyubiquitin chains. Whether the proteasome also can bind atypical…”
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Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions by Nobre, Luis V, Nightingale, Katie, Ravenhill, Benjamin J, Antrobus, Robin, Soday, Lior, Nichols, Jenna, Davies, James A, Seirafian, Sepehr, Wang, Eddie Cy, Davison, Andrew J, Wilkinson, Gavin Wg, Stanton, Richard J, Huttlin, Edward L, Weekes, Michael P

“…Human cytomegalovirus (HCMV) extensively modulates host cells, downregulating >900 human proteins during viral replication and degrading ≥133 proteins shortly…”
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Quantitative Temporal Proteomic Analysis of Vaccinia Virus Infection Reveals Regulation of Histone Deacetylases by an Interferon Antagonist by Soday, Lior, Lu, Yongxu, Albarnaz, Jonas D., Davies, Colin T.R., Antrobus, Robin, Smith, Geoffrey L., Weekes, Michael P.

“…Vaccinia virus (VACV) has numerous immune evasion strategies, including multiple mechanisms of inhibition of interferon regulatory factor 3 (IRF-3), nuclear…”
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Quantitative proteomics defines mechanisms of antiviral defence and cell death during modified vaccinia Ankara infection by Albarnaz, Jonas D., Kite, Joanne, Oliveira, Marisa, Li, Hanqi, Di, Ying, Christensen, Maria H., Paulo, Joao A., Antrobus, Robin, Gygi, Steven P., Schmidt, Florian I., Huttlin, Edward L., Smith, Geoffrey L., Weekes, Michael P.

“…Modified vaccinia Ankara (MVA) virus does not replicate in human cells and is the vaccine deployed to curb the current outbreak of mpox. Here, we conduct a…”
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Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation by Fielding, Ceri A, Aicheler, Rebecca, Stanton, Richard J, Wang, Eddie C Y, Han, Song, Seirafian, Sepehr, Davies, James, McSharry, Brian P, Weekes, Michael P, Antrobus, P Robin, Prod'homme, Virginie, Blanchet, Fabien P, Sugrue, Daniel, Cuff, Simone, Roberts, Dawn, Davison, Andrew J, Lehner, Paul J, Wilkinson, Gavin W G, Tomasec, Peter

“…NKG2D plays a major role in controlling immune responses through the regulation of natural killer (NK) cells, αβ and γδ T-cell function. This activating…”
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A Temporal Proteomic Map of Epstein-Barr Virus Lytic Replication in B Cells by Ersing, Ina, Nobre, Luis, Wang, Liang Wei, Soday, Lior, Ma, Yijie, Paulo, Joao A., Narita, Yohei, Ashbaugh, Camille W., Jiang, Chang, Grayson, Nicholas E., Kieff, Elliott, Gygi, Steven P., Weekes, Michael P., Gewurz, Benjamin E.

“…Epstein-Barr virus (EBV) replication contributes to multiple human diseases, including infectious mononucleosis, nasopharyngeal carcinoma, B cell lymphomas,…”
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Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers by Ferris, Mark, Ferris, Rebecca, Workman, Chris, O'Connor, Eoin, Enoch, David A, Goldesgeyme, Emma, Quinnell, Natalie, Patel, Parth, Wright, Jo, Martell, Geraldine, Moody, Christine, Shaw, Ashley, Illingworth, Christopher Jr, Matheson, Nicholas J, Weekes, Michael P

“…Respiratory protective equipment recommended in the UK for healthcare workers (HCWs) caring for patients with COVID-19 comprises a fluid-resistant surgical…”
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Temporal Proteomic Analysis of Herpes Simplex Virus 1 Infection Reveals Cell-Surface Remodeling via pUL56-Mediated GOPC Degradation by Soh, Timothy K., Davies, Colin T.R., Muenzner, Julia, Hunter, Leah M., Barrow, Henry G., Connor, Viv, Bouton, Clément R., Smith, Cameron, Emmott, Edward, Antrobus, Robin, Graham, Stephen C., Weekes, Michael P., Crump, Colin M.

“…Herpesviruses are ubiquitous in the human population and they extensively remodel the cellular environment during infection. Multiplexed quantitative proteomic…”
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Plasma membrane profiling defines an expanded class of cell surface proteins selectively targeted for degradation by HCMV US2 in cooperation with UL141 by Hsu, Jye-Lin, van den Boomen, Dick J H, Tomasec, Peter, Weekes, Michael P, Antrobus, Robin, Stanton, Richard J, Ruckova, Eva, Sugrue, Daniel, Wilkie, Gavin S, Davison, Andrew J, Wilkinson, Gavin W G, Lehner, Paul J

“…Human cytomegalovirus (HCMV) US2, US3, US6 and US11 act in concert to prevent immune recognition of virally infected cells by CD8+ T-lymphocytes through…”
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Proteomic analysis of circulating immune cells identifies cellular phenotypes associated with COVID-19 severity by Potts, Martin, Fletcher-Etherington, Alice, Nightingale, Katie, Mescia, Federica, Bergamaschi, Laura, Calero-Nieto, Fernando J., Antrobus, Robin, Williamson, James, Parsons, Harriet, Huttlin, Edward L., Kingston, Nathalie, Göttgens, Berthold, Bradley, John R., Lehner, Paul J., Matheson, Nicholas J., Smith, Kenneth G.C., Wills, Mark R., Lyons, Paul A., Weekes, Michael P.

“…Certain serum proteins, including C-reactive protein (CRP) and D-dimer, have prognostic value in patients with severe acute respiratory syndrome coronavirus 2…”
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Demographic, behavioural and occupational risk factors associated with SARS-CoV-2 infection in UK healthcare workers: a retrospective observational study by Cooper, Daniel James, Lear, Sara, Sithole, Nyarie, Shaw, Ashley, Stark, Hannah, Ferris, Mark, Bradley, John, Maxwell, Patrick, Goodfellow, Ian, Weekes, Michael P, Seaman, Shaun, Baker, Stephen

“…ObjectiveHealthcare workers (HCWs) are at higher risk of SARS-CoV-2 infection than the general population. This group is pivotal to healthcare system…”
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