Search Results - "Weeke, Lauren C"
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A Novel Magnetic Resonance Imaging Score Predicts Neurodevelopmental Outcome After Perinatal Asphyxia and Therapeutic Hypothermia
Published in The Journal of pediatrics (01-01-2018)“…To assess the predictive value of a novel magnetic resonance imaging (MRI) score, which includes diffusion-weighted imaging as well as assessment of the deep…”
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Effect of general anesthesia on neonatal aEEG-A cohort study of patients with non-cardiac congenital anomalies
Published in PloS one (31-08-2017)“…The aim of the current study was to determine the effect of general anesthesia on neonatal brain activity using amplitude-integrated EEG (aEEG). A prospective…”
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Trametinib restores the central conducting lymphatic flow in a premature infant with Noonan syndrome
Published in Clinical case reports (01-07-2024)“…Key Clinical Message We describe a premature hydropic infant with Noonan syndrome and a therapy refractory chylothorax. This was shown to be due to a central…”
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Perinatal thalamic injury: MRI predictors of electrical status epilepticus in sleep and long-term neurodevelopment
Published in NeuroImage clinical (01-01-2020)“…•The majority of patients with perinatal thalamic injury, will develop epilepsy with ESES after the age of two years.•ESES is associated with…”
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MRI scoring systems for long-term outcome prediction in Neonatal Encephalopathy due to hypoxia-ischemia: in search of the crystal ball
Published in Pediatric research (15-07-2024)Get full text
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Neonatal Seizure Management: Is the Timing of Treatment Critical?
Published in The Journal of pediatrics (01-04-2022)“…To assess the impact of the time to treatment of the first electrographic seizure on subsequent seizure burden and describe overall seizure management in a…”
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Characterisation of neonatal seizures and their treatment using continuous EEG monitoring: a multicentre experience
Published in Archives of disease in childhood. Fetal and neonatal edition (01-09-2019)“…The aim of this multicentre study was to describe detailed characteristics of electrographic seizures in a cohort of neonates monitored with multichannel…”
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The development and validation of a cerebral ultrasound scoring system for infants with hypoxic-ischaemic encephalopathy
Published in Pediatric research (01-03-2020)“…Background Hypoxic-ischaemic encephalopathy (HIE) is an important cause of morbidity and mortality in neonates. When the gold standard MRI is not feasible,…”
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A Distinctive Ictal Amplitude-Integrated Electroencephalography Pattern in Newborns with Neonatal Epilepsy Associated with KCNQ2 Mutations
Published in Neonatology (Basel, Switzerland) (01-01-2017)“…Recurrent and prolonged seizures are harmful for the developing brain, emphasizing the importance of early seizure recognition and effective therapy…”
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A machine-learning algorithm for neonatal seizure recognition: a multicentre, randomised, controlled trial
Published in The lancet child & adolescent health (01-10-2020)“…Despite the availability of continuous conventional electroencephalography (cEEG), accurate diagnosis of neonatal seizures is challenging in clinical practice…”
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Early recognition of characteristic conventional and amplitude-integrated EEG patterns of seizures in SCN2A and KCNQ3-related epilepsy in neonates
Published in Seizure (London, England) (01-08-2023)“…•Case series of SCN2A and KCNQ3-associated epilepsy.•Unique semiology with tonic seizures with apnea and desaturation.•aEEG and EEG show a characteristic ictal…”
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Amplitude-Integrated Electroencephalography for Early Recognition of Brain Injury in Neonates with Critical Congenital Heart Disease
Published in The Journal of pediatrics (01-11-2018)“…To study perioperative amplitude-integrated electroencephalography (aEEG) as an early marker for new brain injury in neonates requiring cardiac surgery for…”
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Rhythmic EEG patterns in extremely preterm infants: Classification and association with brain injury and outcome
Published in Clinical neurophysiology (01-12-2017)“…•Most rhythmic EEG patterns in extremely preterm infants related to head position.•Clear ictal discharges were only observed in one out of 77 infants…”
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A Comparison of the Thompson Encephalopathy Score and Amplitude-Integrated Electroencephalography in Infants with Perinatal Asphyxia and Therapeutic Hypothermia
Published in Neonatology (Basel, Switzerland) (01-01-2017)“…In previous studies clinical signs or amplitude-integrated electroencephalography (aEEG)-based signs of encephalopathy were used to select infants with…”
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The aetiology of neonatal seizures and the diagnostic contribution of neonatal cerebral magnetic resonance imaging
Published in Developmental medicine and child neurology (01-03-2015)“…Aim The aim of this study was to delineate aetiologies and explore the diagnostic value of cerebral magnetic resonance imaging (MRI) in addition to cranial…”
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Lidocaine response rate in aEEG‐confirmed neonatal seizures: Retrospective study of 413 full‐term and preterm infants
Published in Epilepsia (Copenhagen) (01-02-2016)“…Summary Objective To investigate the seizure response rate to lidocaine in a large cohort of infants who received lidocaine as second‐ or third‐line…”
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Role of EEG background activity, seizure burden and MRI in predicting neurodevelopmental outcome in full-term infants with hypoxic-ischaemic encephalopathy in the era of therapeutic hypothermia
Published in European journal of paediatric neurology (01-11-2016)“…Abstract Objective To investigate the role of EEG background activity, electrographic seizure burden, and MRI in predicting neurodevelopmental outcome in…”
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Punctate White Matter Lesions in Full-Term Infants with Neonatal Seizures Associated with SLC13A5 Mutations
Published in European journal of paediatric neurology (01-03-2017)“…Abstract Introduction Early-onset epileptic encephalopathy caused by biallelic SLC13A5 mutations is characterized by seizure onset in the first days of life,…”
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Severe hypercapnia causes reversible depression of aEEG background activity in neonates: an observational study
Published in Archives of disease in childhood. Fetal and neonatal edition (01-09-2017)“…Elevated carbon dioxide (CO ) blood levels have a depressant effect on the central nervous system and can lead to coma in adults. Less is known about the…”
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Lidocaine-Associated Cardiac Events in Newborns with Seizures: Incidence, Symptoms and Contributing Factors
Published in Neonatology (Basel, Switzerland) (01-01-2015)“…Lidocaine is an effective therapy for neonatal seizures; however, it is not widely used, presumably due to the risk of cardiac events. To investigate the…”
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