Search Results - "Wedegaertner, Philip"

Functional selectivity of GPCR-directed drug action through location bias by Irannejad, Roshanak, Pessino, Veronica, Mika, Delphine, Huang, Bo, Wedegaertner, Philip B, Conti, Marco, von Zastrow, Mark

“…Intracellular G s -cAMP signaling from β 1 -adrenergic receptors residing in the Golgi represents ‘location bias’, a new form of GPCR functional selectivity…”
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Gβγ signaling regulates microtubule-dependent control of Golgi integrity by Rajanala, Kalpana, Wedegaertner, Philip B.

“…Gβγ subunits regulate several non-canonical functions at distinct intracellular organelles. Previous studies have shown that Gβγ signaling at the Golgi is…”
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Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma by Chua, Vivian, Lapadula, Dominic, Randolph, Clinita, Benovic, Jeffrey L, Wedegaertner, Philip B, Aplin, Andrew E

“…Uveal melanoma is the most common primary intraocular malignant tumor in adults and arises from the transformation of melanocytes in the uveal tract. Even…”
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Disruption of the interaction between mutationally activated Gαq and Gβγ attenuates aberrant signaling by Aumiller, Jenna L., Wedegaertner, Philip B.

“…Heterotrimeric G protein stimulation via G protein–coupled receptors promotes downstream proliferative signaling. Mutations can occur in Gα proteins which…”
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Gβγ regulates mitotic Golgi fragmentation and G2/M cell cycle progression by Rajanala, Kalpana, Klayman, Lauren M, Wedegaertner, Philip B

“…Heterotrimeric G proteins (αβγ) function at the cytoplasmic surface of a cell's plasma membrane to transduce extracellular signals into cellular responses…”
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Non-canonical signaling and localizations of heterotrimeric G proteins by Hewavitharana, Thamara, Wedegaertner, Philip B.

“…Heterotrimeric G proteins typically transduce signals from G protein-coupled receptors (GPCRs) to effector proteins. In the conventional G protein signaling…”
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Effects of Oncogenic Gαq and Gα11 Inhibition by FR900359 in Uveal Melanoma by Lapadula, Dominic, Farias, Eduardo, Randolph, Clinita E., Purwin, Timothy J., McGrath, Dougan, Charpentier, Thomas H., Zhang, Lihong, Wu, Shihua, Terai, Mizue, Sato, Takami, Tall, Gregory G., Zhou, Naiming, Wedegaertner, Philip B., Aplin, Andrew E., Aguirre-Ghiso, Julio, Benovic, Jeffrey L.

“…Abstract Uveal melanoma is the most common intraocular tumor in adults and often metastasizes to the liver, leaving patients with few options. Recurrent…”
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Inducible Inhibition of Gβγ Reveals Localization-dependent Functions at the Plasma Membrane and Golgi by Klayman, Lauren M., Wedegaertner, Philip B.

“…Heterotrimeric G proteins signal at a variety of endomembrane locations, in addition to their canonical function at the cytoplasmic surface of the plasma…”
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Regulation of Constitutive Cargo Transport from the trans-Golgi Network to Plasma Membrane by Golgi-localized G Protein βγ Subunits by Irannejad, Roshanak, Wedegaertner, Philip B.

“…Observations of Golgi fragmentation upon introduction of G protein βγ (Gβγ) subunits into cells have implicated Gβγ in a pathway controlling the fission at the…”
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PAQR3 regulates Golgi vesicle fission and transport via the Gβγ–PKD signaling pathway by Hewavitharana, Thamara, Wedegaertner, Philip B.

“…Heterotrimeric G proteins function at diverse subcellular locations, in addition to canonical signaling at the plasma membrane (PM). Gβγ signals at the Golgi,…”
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Enhanced membrane binding of oncogenic G protein αqQ209L confers resistance to inhibitor YM-254890 by Randolph, Clinita E., Dwyer, Morgan B., Aumiller, Jenna L., Dixon, Alethia J., Inoue, Asuka, Osei-Owusu, Patrick, Wedegaertner, Philip B.

“…Heterotrimeric G proteins couple activated G protein–coupled receptors (GPCRs) to intracellular signaling pathways. They can also function independently of…”
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Assembly and Trafficking of Heterotrimeric G Proteins by Marrari, Yannick, Crouthamel, Marykate, Irannejad, Roshanak, Wedegaertner, Philip B

“…To be activated by cell surface G protein-coupled receptors, heterotrimeric G proteins must localize at the cytoplasmic surface of plasma membranes. Moreover,…”
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G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling by Xiao, Pingping, Huang, Xishi, Huang, Lanzhen, Yang, Jing, Li, Ang, Shen, Ke, Wedegaertner, Philip B., Jiang, Xiaoshan

“…Senescent cells have lost their capacity for proliferation and manifest as irreversibly in cell cycle arrest. Many membrane receptors, including G…”
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Lipid–protein interactions in GPCR-associated signaling by Escribá, Pablo V., Wedegaertner, Philip B., Goñi, Félix M., Vögler, Oliver

“…Signal transduction via G-protein-coupled receptors (GPCRs) is a fundamental pathway through which the functions of an individual cell can be integrated within…”
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Prognostic Values of G-Protein Mutations in Metastatic Uveal Melanoma by Terai, Mizue, Shimada, Ayako, Chervoneva, Inna, Hulse, Liam, Danielson, Meggie, Swensen, Jeff, Orloff, Marlana, Wedegaertner, Philip B, Benovic, Jeffrey L, Aplin, Andrew E, Sato, Takami

“…Uveal melanoma is the most common primary ocular malignancy in adults, characterized by gene mutations in G protein subunit alpha q ( ) and G protein subunit…”
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Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission by Martz, Matthew K, Grabocka, Elda, Beeharry, Neil, Yen, Timothy J, Wedegaertner, Philip B

“…Proper completion of mitosis requires the concerted effort of multiple RhoGEFs. Here we show that leukemia-associated RhoGEF (LARG), a RhoA-specific…”
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The regulator of G protein signaling (RGS) domain of G protein-coupled receptor kinase 5 (GRK5) regulates plasma membrane localization and function by Xu, Hua, Jiang, Xiaoshan, Shen, Ke, Fischer, Christopher C, Wedegaertner, Philip B

“…The G protein-coupled receptor (GPCR) kinases (GRKs) phosphorylate activated GPCRs at the plasma membrane (PM). Here GRK5/GRK4 chimeras and point mutations in…”
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FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts by Iwanicki, Marcin P, Vomastek, Tomas, Tilghman, Robert W, Martin, Karen H, Banerjee, Jayashree, Wedegaertner, Philip B, Parsons, J Thomas

“…A key step in cell migration is the dynamic formation and disassembly of adhesions at the front and the concomitant movement and release of adhesions in the…”
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Co-Targeting FASN and mTOR Suppresses Uveal Melanoma Growth by Han, Anna, Mukha, Dzmitry, Chua, Vivian, Purwin, Timothy J, Tiago, Manoela, Modasia, Bhavik, Baqai, Usman, Aumiller, Jenna L, Bechtel, Nelisa, Hunter, Emily, Danielson, Meggie, Terai, Mizue, Wedegaertner, Philip B, Sato, Takami, Landreville, Solange, Davies, Michael A, Kurtenbach, Stefan, Harbour, J William, Schug, Zachary T, Aplin, Andrew E

“…Uveal melanoma (UM) displays a high frequency of metastasis; however, effective therapies for metastatic UM are limited. Identifying unique metabolic features…”
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Mitotic-dependent phosphorylation of leukemia-associated RhoGEF (LARG) by Cdk1 by Helms, Michelle C., Grabocka, Elda, Martz, Matthew K., Fischer, Christopher C., Suzuki, Nobuchika, Wedegaertner, Philip B.

“…Rho GTPases are integral to the regulation of actin cytoskeleton-dependent processes, including mitosis. Rho and leukemia-associated Rho guanine-nucleotide…”
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