Search Results - "Weddell, Jared"

Mechanistically modeling peripheral cytokine dynamics following bispecific dosing in solid tumors by Weddell, Jared

“…Bispecific antibodies exhibit proven clinical benefit, and many bispecifics are currently in clinical development for oncology. Cytokine release syndrome (CRS)…”
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Hemodynamic analysis in an idealized artery tree: differences in wall shear stress between Newtonian and non-Newtonian blood models by Weddell, Jared C, Kwack, JaeHyuk, Imoukhuede, P I, Masud, Arif

“…Development of many conditions and disorders, such as atherosclerosis and stroke, are dependent upon hemodynamic forces. To accurately predict and prevent…”
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Quantitative characterization of cellular membrane-receptor heterogeneity through statistical and computational modeling by Weddell, Jared C, Imoukhuede, P I

“…Cell population heterogeneity can affect cellular response and is a major factor in drug resistance. However, there are few techniques available to represent…”
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Discovery of High-Affinity PDGF-VEGFR Interactions: Redefining RTK Dynamics by Mamer, Spencer B., Chen, Si, Weddell, Jared C., Palasz, Alexandra, Wittenkeller, Ashley, Kumar, Manu, Imoukhuede, P. I.

“…Nearly all studies of angiogenesis have focused on uni-family ligand-receptor binding, e.g., VEGFs bind to VEGF receptors, PDGFs bind to PDGF receptors, etc…”
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VEGFR1 promotes cell migration and proliferation through PLCγ and PI3K pathways by Weddell, Jared C., Chen, Si, Imoukhuede, P. I.

“…The ability to control vascular endothelial growth factor (VEGF) signaling offers promising therapeutic potential for vascular diseases and cancer. Despite…”
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Integrative meta-modeling identifies endocytic vesicles, late endosome and the nucleus as the cellular compartments primarily directing RTK signaling by Weddell, Jared C, Imoukhuede, Princess I

“…Recently, intracellular receptor signaling has been identified as a key component mediating cell responses for various receptor tyrosine kinases (RTKs)…”
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Author Correction: Discovery of High-Affinity PDGF-VEGFR Interactions: Redefining RTK Dynamics by Mamer, Spencer B., Chen, Si, Weddell, Jared C., Palasz, Alexandra, Wittenkeller, Ashley, Kumar, Manu, Imoukhuede, P. I.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Mechanistic Modeling of Intra‐Tumor Spatial Distribution of Antibody‐Drug Conjugates: Insights into Dosing Strategies in Oncology by Weddell, Jared, Chiney, Manoj S., Bhatnagar, Sumit, Gibbs, John P., Shebley, Mohamad

“…Antibody drug conjugates (ADCs) provide targeted delivery of cytotoxic agents directly inside tumor cells. However, many ADCs targeting solid tumors have…”
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Cell isolation via spiral microfluidics and the secondary anchor targeted cell release system by Ansari, Ali, Schultheis, Kinsey, Patel, Reema, Al‐Qadi, Kareem I., Chen, Si, Jensen, Cassandra R., Schad, Samantha R., Weddell, Jared C., Vanka, Surya P., Imoukhuede, P. I.

“…Precision medicine requires high throughput cell isolation and measurement that maintains physiology. Unfortunately, many techniques are slow or alter cell…”
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Recommendations for a standardized publication protocol for a QSP model by Weddell, Jared, Gulati, Abhishek, Yamada, Akihiro

“…Development of a Quantitative Systems Pharmacology (QSP) model is a long process with many iterative steps. Lack of standard practices for publishing QSP…”
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Prospective approaches to gene therapy computational modeling – spotlight on viral gene therapy by Choules, Mary P, Bonate, Peter L., Heo, Nakyo, Weddell, Jared

“…Clinical studies have found there still exists a lack of gene therapy dose-toxicity and dose-efficacy data that causes gene therapy dose selection to remain…”
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Quantitative Systems Pharmacology Approaches for Immuno‐Oncology: Adding Virtual Patients to the Development Paradigm by Chelliah, Vijayalakshmi, Lazarou, Georgia, Bhatnagar, Sumit, Gibbs, John P., Nijsen, Marjoleen, Ray, Avijit, Stoll, Brian, Thompson, R. Adam, Gulati, Abhishek, Soukharev, Serguei, Yamada, Akihiro, Weddell, Jared, Sayama, Hiroyuki, Oishi, Masayo, Wittemer‐Rump, Sabine, Patel, Chirag, Niederalt, Christoph, Burghaus, Rolf, Scheerans, Christian, Lippert, Jörg, Kabilan, Senthil, Kareva, Irina, Belousova, Natalya, Rolfe, Alex, Zutshi, Anup, Chenel, Marylore, Venezia, Filippo, Fouliard, Sylvain, Oberwittler, Heike, Scholer‐Dahirel, Alix, Lelievre, Helene, Bottino, Dean, Collins, Sabrina C., Nguyen, Hoa Q., Wang, Haiqing, Yoneyama, Tomoki, Zhu, Andy Z.X., Graaf, Piet H., Kierzek, Andrzej M.

“…Drug development in oncology commonly exploits the tools of molecular biology to gain therapeutic benefit through reprograming of cellular responses. In…”
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Integrative meta-modeling identifies endocytic vesicles, late endosome and the nucleus as the cellular compartments primarily directing RTK signalingElectronic supplementary information (ESI) available. See DOI: 10.1039/c7ib00011a by Weddell, Jared C, Imoukhuede, Princess I

“…Recently, intracellular receptor signaling has been identified as a key component mediating cell responses for various receptor tyrosine kinases (RTKs)…”
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qFlow Cytometry-Based Receptoromic Screening: A High-Throughput Quantification Approach Informing Biomarker Selection and Nanosensor Development by Chen, Si, Weddell, Jared, Gupta, Pavan, Conard, Grace, Parkin, James, Imoukhuede, Princess I

“…Nanosensor-based detection of biomarkers can improve medical diagnosis; however, a critical factor in nanosensor development is deciding which biomarker to…”
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Predicting Angiogenic Receptor Trafficking and Signaling via Computational Systems Biology by Weddell, Jared Colin

“…Angiogenesis is defined as the growth of new blood vessels from preexisting vessels. Systematic regulation of angiogenesis could lead to new treatments of…”
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