Angio-oedema induced by enalapril

We report the case of a patient who, 9 months after initiation of enalapril and hydrochlorothiazide combination treatment for hypertension, developed angio-oedema with near fatal outcome. Our patient was successfully intubated using a flexible bronchofiberoscope. This case demonstrates that patients...

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Bibliographic Details
Published in:	Journal of internal medicine Vol. 238; no. 2; p. 179
Main Authors:	Forslund, T, Tohmo, H, Weckström, G, Stenborg, M, Järvinen, S
Format:	Journal Article
Language:	English
Published:	England 01-08-1995
Subjects:	Angioedema - chemically induced Angioedema - therapy Enalapril - adverse effects Humans Intubation, Intratracheal Male Middle Aged
Online Access:	Get more information
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Summary:	We report the case of a patient who, 9 months after initiation of enalapril and hydrochlorothiazide combination treatment for hypertension, developed angio-oedema with near fatal outcome. Our patient was successfully intubated using a flexible bronchofiberoscope. This case demonstrates that patients given an angiotensin-converting enzyme (ACE) inhibitor may develop serious facial and laryngeal swelling even several months after the initiation of treatment. The occurrence of even mild swelling should lead to prompt cessation of the drug. Patients with incipient ACE inhibitor-related angio-oedema should, without any delay, be referred to hospital for emergency treatment.
ISSN:	0954-6820
DOI:	10.1111/j.1365-2796.1995.tb00917.x