Search Results - "Wechuck, James"

Gene therapy for pain: Results of a phase I clinical trial by Fink, David J., Wechuck, James, Mata, Marina, Glorioso, Joseph C., Goss, James, Krisky, David, Wolfe, Darren

“…Objective: Preclinical evidence indicates that gene transfer to the dorsal root ganglion using replication‐defective herpes simplex virus (HSV)‐based vectors…”
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A Clinical Trial of Gene Therapy for Chronic Pain by Wolfe, Darren, Wechuck, James, Krisky, David, Mata, Marina, Fink, David J.

“…ABSTRACT The first human trial of gene therapy for chronic pain, a phase 1 study of a nonreplicating herpes simplex virus (HSV)‐based vector engineered to…”
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Herpes Simplex Virus‐Mediated Expression of Pax3 and MyoD in Embryoid Bodies Results in Lineage‐Related Alterations in Gene Expression Profiles by Craft, April M., Krisky, David M., Wechuck, James B., Lobenhofer, Edward K., Jiang, Ying, Wolfe, Darren P., Glorioso, Joseph C.

“…The ability of embryonic stem cells to develop into multiple cell lineages provides a powerful resource for tissue repair and regeneration. Gene transfer…”
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Construction and production of recombinant herpes simplex virus vectors by Goins, William F, Krisky, David M, Wechuck, James B, Huang, Shaohua, Glorioso, Joseph C

“…Virus vectors have been employed as gene transfer vehicles for various pre-clinical and clinical gene therapy applications. Replication-competent herpes…”
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Immobilized Cobalt Affinity Chromatography Provides a Novel, Efficient Method for Herpes Simplex Virus Type 1 Gene Vector Purification by CANPING JIANG, WECHUCK, James B, GOINS, William F, KRISKY, David M, WOLFE, Darren, ATAAI, Mohammad M, GLORIOSO, Joseph C

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Generation of replication-competent and -defective HSV vectors by Goins, William F, Krisky, David M, Wechuck, James B, Wolfe, Darren, Huang, Shaohua, Glorioso, Joseph C

“…Engineering effective vectors has been crucial to the efficient delivery and expression of therapeutic gene products in vivo. Among these, HSV-1 represents an…”
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Inactivation of herpes simplex type 1 gene vector on immobilized metal affinity chromatography: Oxidative damage by hydroxyl free radicals and its prevention by Jiang, Canping, Ataai, Mohammad, Ozuer, Ali, Krisky, David, Wechuck, James, Pornsuwan, Soraya, Pourarian, Fazard, Glorioso, Joseph C.

“…Metal catalyzed oxidation (MCO), which typically involves oxygen free radical generation, is an important pathway that leads to the deterioration of many…”
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Effect of genetic background and culture conditions on the production of herpesvirus-based gene therapy vectors by Ozuer, Ali, Wechuck, James B., Goins, William F., Wolfe, Darren, Glorioso, Joseph C., Ataai, Mohammad M.

“…Herpes simplex virus type‐1 (HSV‐1) represents a unique vehicle for the introduction of foreign DNA to cells of a variety of tissues. The nature of the vector,…”
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Effect of temperature, medium composition, and cell passage on production of herpes-based viral vectors by Wechuck, James B., Ozuer, Ali, Goins, William F., Wolfe, Darren, Oligino, Thomas, Glorioso, Joseph C., Ataai, Mohammad M.

“…Our work uses replication‐defective genomic herpes simplex virus type‐1 (HSV‐1)‐based vectors to transfer therapeutic genes into cells of the central nervous…”
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Evaluation of Infection Parameters in the Production of Replication-Defective HSV-1 Viral Vectors by Ozuer, Ali, Wechuck, James B., Russell, Brian, Wolfe, Darren, Goins, William F., Glorioso, Joseph C., Ataai, Mohammad M.

“…Herpes simplex virus type‐1 (HSV‐1) is a neurotrophic human pathogen that establishes life‐long latency in the nervous system. Our laboratory has extensively…”
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Clinical trial links oncolytic immunoactivation to survival in glioblastoma by Ling, Alexander L., Solomon, Isaac H., Landivar, Ana Montalvo, Nakashima, Hiroshi, Woods, Jared K., Santos, Andres, Masud, Nafisa, Fell, Geoffrey, Mo, Xiaokui, Yilmaz, Ayse S., Grant, James, Zhang, Abigail, Bernstock, Joshua D., Torio, Erickson, Ito, Hirotaka, Liu, Junfeng, Shono, Naoyuki, Nowicki, Michal O., Triggs, Daniel, Halloran, Patrick, Piranlioglu, Raziye, Soni, Himanshu, Stopa, Brittany, Bi, Wenya Linda, Peruzzi, Pierpaolo, Chen, Ethan, Malinowski, Seth W., Prabhu, Michael C., Zeng, Yu, Carlisle, Anne, Rodig, Scott J., Wen, Patrick Y., Lee, Eudocia Quant, Nayak, Lakshmi, Chukwueke, Ugonma, Gonzalez Castro, L. Nicolas, Dumont, Sydney D., Batchelor, Tracy, Kittelberger, Kara, Tikhonova, Ekaterina, Miheecheva, Natalia, Tabakov, Dmitry, Shin, Nara, Gorbacheva, Alisa, Shumskiy, Artemy, Frenkel, Felix, Aguilar-Cordova, Estuardo, Aguilar, Laura K., Krisky, David, Wechuck, James, Manzanera, Andrea, Matheny, Chris, Tak, Paul P., Barone, Francesca, Kovarsky, Daniel, Tirosh, Itay, Suvà, Mario L., Wucherpfennig, Kai W., Ligon, Keith, Reardon, David A., Chiocca, E. Antonio

“…Immunotherapy failures can result from the highly suppressive tumour microenvironment that characterizes aggressive forms of cancer such as recurrent…”
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Delivery of herpes simplex virus-based vectors to stem cells by Wolfe, Darren, Wechuck, James B, Krisky, David M, Goff, Julie P, Goins, William F, Ozuer, Ali, Epperly, Michael E, Greenberger, Joel S, Fink, David J, Glorioso, Joseph C

“…In contrast to traditional drugs that generally act by altering existing gene product function, gene therapy aims to target the root cause of the disease by…”
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184. PGN-503, a Herpes Simplex Virus Based Vector Expressing Neurotrophin-3, Prevents and Reverses Neuropathy in a Mouse Model of Paclitaxel-Induced Peripheral Neuropathy by Goss, James R., Krisky, David, Bouch, Karen, O'Malley, Mark, Coghlan, Sarah, Wechuck, James

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Effect of Protease Inhibitors on Yield of HSV-1-Based Viral Vectors by Wechuck, James B., Goins, William F., Glorioso, Joseph C., Ataai, Mohammad M.

“…The ability to obtain high titer replication‐defective herpes simplex virus (HSV) recombinant vectors will dramatically affect their use in gene therapy…”
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Herpes simplex virus-based nerve targeting gene therapy in pain management by Goss, James R, Krisky, David, Wechuck, James, Wolfe, Darren

“…Chronic pain represents a major medical burden not only in terms of suffering but also in terms of economic costs. Traditional medical approaches have so far…”
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HSV-Mediated Delivery of Erythropoietin Restores Dopaminergic Function in MPTP-Treated Mice by Puskovic, Veljko, Wolfe, Darren, Wechuck, James, Krisky, David, Collins, Jeff, Glorioso, Joseph C, Fink, David J, Mata, Marina

“…To investigate the neuroprotective effects of erythropoietin (EPO) in a rodent model of Parkinson disease, we inoculated a nonreplicating herpes simplex…”
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Herpes simplex virus vector-mediated delivery of neurturin rescues erectile dysfunction of cavernous nerve injury by Kato, R, Wolfe, D, Coyle, C H, Wechuck, J B, Tyagi, P, Tsukamoto, T, Nelson, J B, Glorioso, J C, Chancellor, M B, Yoshimura, N

“…Neurturin (NTN), a member of glial cell line-derived neurotrophic factor (GDNF) family, is known as an important neurotrophic factor for penis-projecting…”
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355. A Platform for Gene Delivery to Embryonic Stem Cells Using HSV by Sunyog, April M., Wolfe, Darren, Wechuck, James, Krisky, David, Jiang, Ying, Glorioso, Joseph

“…Embryonic development is a complex process involving integrated pathways directing the ordered proliferation, migration, and differentiation of stem cells into…”
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Multiple Applications For Replication‐Defective Herpes Simplex Virus Vectors by Burton, Edward A., Wechuck, James B., Wendell, Steven K., Goins, William F., Fink, David J., Glorioso, Joseph C.

“…Herpes simplex virus (HSV) is a neurotropic DNA virus. The viral genome is large (152 kb), and many genes are dispensable for viral function, allowing…”
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1071. Development and Characterization of HSV-1 Vector-Expressed Dominant Negative PKC epsilon for Pain Therapy by Srinivasan, Rahul, Sculptoreanu, Adrian, Wolfe, Darren, Wechuck, James, Watkins, Simon, de Groat, William C., Glorioso, Joseph C.

“…The vanilloid receptor (TRPV1) is an important pro-nociceptive Ca+2 channel, the inhibition of which attenuates pain. Recent studies have shown that TRPV1…”
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