Search Results - "Wechsler, Caroline S."

An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML by Lin, Shan, Larrue, Clément, Scheidegger, Nastassja K, Seong, Bo Kyung A, Dharia, Neekesh V, Kuljanin, Miljan, Wechsler, Caroline S, Kugener, Guillaume, Robichaud, Amanda L, Conway, Amy Saur, Mashaka, Thelma, Mouche, Sarah, Adane, Biniam, Ryan, Jeremy A, Mancias, Joseph D, Younger, Scott T, Piccioni, Federica, Lee, Lynn H, Wunderlich, Mark, Letai, Anthony, Tamburini, Jérôme, Stegmaier, Kimberly

“…CRISPR-Cas9-based genetic screens have successfully identified cell type-dependent liabilities in cancer, including acute myeloid leukemia (AML), a devastating…”
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A first-generation pediatric cancer dependency map by Dharia, Neekesh V., Kugener, Guillaume, Guenther, Lillian M., Malone, Clare F., Durbin, Adam D., Hong, Andrew L., Howard, Thomas P., Bandopadhayay, Pratiti, Wechsler, Caroline S., Fung, Iris, Warren, Allison C., Dempster, Joshua M., Krill-Burger, John M., Paolella, Brenton R., Moh, Phoebe, Jha, Nishant, Tang, Andrew, Montgomery, Philip, Boehm, Jesse S., Hahn, William C., Roberts, Charles W. M., McFarland, James M., Tsherniak, Aviad, Golub, Todd R., Vazquez, Francisca, Stegmaier, Kimberly

“…Exciting therapeutic targets are emerging from CRISPR-based screens of high mutational-burden adult cancers. A key question, however, is whether functional…”
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A Combination CDK4/6 and IGF1R Inhibitor Strategy for Ewing Sarcoma by Guenther, Lillian M, Dharia, Neekesh V, Ross, Linda, Conway, Amy, Robichaud, Amanda L, Catlett, 2nd, Jerrel L, Wechsler, Caroline S, Frank, Elizabeth S, Goodale, Amy, Church, Alanna J, Tseng, Yuen-Yi, Guha, Rajarshi, McKnight, Crystal G, Janeway, Katherine A, Boehm, Jesse S, Mora, Jaume, Davis, Mindy I, Alexe, Gabriela, Piccioni, Federica, Stegmaier, Kimberly

“…Novel targeted therapeutics have transformed the care of subsets of patients with cancer. In pediatric malignancies, however, with simple tumor genomes and…”
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Evaluation of Gentamicin Exposure in the Neonatal Intensive Care Unit and Hearing Function at Discharge by Puia-Dumitrescu, Mihai, Bretzius, Olivia M., Brown, Nia, Fitz-Henley, James A., Ssengonzi, Rebecca, Wechsler, Caroline S., Gray, Keyaria D., Benjamin, Daniel K., Smith, P. Brian, Clark, Reese H., Gonzalez, Daniel, Hornik, Christoph P.

“…To characterize the association between gentamicin dosing, duration of treatment, and ototoxicity in hospitalized infants. This retrospective cohort study…”
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Abstract 3912: ATM and PARP combined inhibition demonstrate synergistic antitumor efficacy in osteosarcoma models by Kocinsky, Sona N., Morsby, Janeala J., Wright, William C., Wierdl, Monika, Wechsler, Caroline S., Alexe, Gabriela, Geeleher, Paul, Stegmaier, Kimberly, Guenther, Lillian M.

“…Abstract Signatures of BRCAness are found in many osteosarcoma (OS) tumors, driving an interest in PARP inhibition (PARPi) for OS treatment. Although PARPi…”
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