Search Results - "Wechselberger, Martin"
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The Role of Cell Volume in the Dynamics of Seizure, Spreading Depression, and Anoxic Depolarization
Published in PLoS computational biology (01-08-2015)“…Cell volume changes are ubiquitous in normal and pathological activity of the brain. Nevertheless, we know little of how cell volume affects neuronal dynamics…”
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Giant squid-hidden canard: the 3D geometry of the Hodgkin-Huxley model
Published in Biological cybernetics (01-07-2007)“…This work is motivated by the observation of remarkably slow firing in the uncoupled Hodgkin-Huxley model, depending on parameters tau( h ), tau( n ) that…”
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{A} propos de canards (Apropos canards)
Published in Transactions of the American Mathematical Society (01-06-2012)“…We extend canard theory of singularly perturbed systems to the general case of k fast dimensions, with k\ge 2 arbitrary. A folded critical manifold of a…”
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Bifurcations of mixed-mode oscillations in a stellate cell model
Published in Physica. D (01-08-2009)“…Experimental recordings of the membrane potential of stellate cells within the entorhinal cortex show a transition from subthreshold oscillations (STOs) via…”
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Multiple Timescales, Mixed Mode Oscillations and Canards in Models of Intracellular Calcium Dynamics
Published in Journal of nonlinear science (01-10-2011)Get full text
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Ionic channels and conductance-based models for hypothalamic neuronal thermosensitivity
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01-09-2006)“…Thermoregulatory responses are partially controlled by the preoptic area and anterior hypothalamus (PO/AH), which contains a mixed population of…”
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Local analysis near a folded saddle-node singularity
Published in Journal of Differential Equations (01-06-2010)“…Folded saddle-nodes occur generically in one parameter families of singularly perturbed systems with two slow variables. We show that these folded…”
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Singularly perturbed boundary-focus bifurcations
Published in Journal of Differential Equations (25-09-2021)“…We consider smooth systems limiting as ϵ→0 to piecewise-smooth (PWS) systems with a boundary-focus (BF) bifurcation. After deriving a suitable local normal…”
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Shock-fronted travelling waves in a reaction–diffusion model with nonlinear forward–backward–forward diffusion
Published in Physica. D (01-09-2021)“…Reaction–diffusion equations (RDEs) are often derived as continuum limits of lattice-based discrete models. Recently, a discrete model which allows the rates…”
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Mixed-Mode Oscillations with Multiple Time Scales
Published in SIAM review (01-01-2012)“…Mixed-mode oscillations (MMOs) are trajectories of a dynamical system in which there is an alternation between oscillations of distinct large and small…”
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Slow Unfoldings of Contact Singularities in Singularly Perturbed Systems Beyond the Standard Form
Published in Journal of nonlinear science (01-12-2020)“…We develop the contact singularity theory for singularly perturbed (or ‘slow–fast’) vector fields of the general form z ′ = H ( z , ε ) , z ∈ R n and 0 < ε ≪ 1…”
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The selection of mixed-mode oscillations in a Hodgkin-Huxley model with multiple timescales
Published in Chaos (Woodbury, N.Y.) (01-03-2008)“…In recent work [J. Rubin and M. Wechselberger, Biol. Cybern. 97, 5 (2007)], we explained the appearance of remarkably slow oscillations in the classical…”
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Mucus clears from the trachea in a helix: a new twist to understanding airway diseases
Published in Thorax (14-06-2024)“…Mucociliary clearance (MCC) is critical to lung health and is impaired in many diseases. The path of MCC may have an important impact on clearance but has…”
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On the stability of shocks in isothermal black hole accretion discs
Published in Monthly notices of the Royal Astronomical Society (18-04-2022)“…ABSTRACT Most black holes possess accretion discs. Models of such discs inform observations and constrain the properties of the black holes and their…”
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Effects of quasi-steady-state reduction on biophysical models with oscillations
Published in Journal of theoretical biology (21-03-2016)“…Many biophysical models have the property that some variables in the model evolve much faster than others. A common step in the analysis of such systems is to…”
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Mixed mode oscillations as a mechanism for pseudo-plateau bursting
Published in Journal of computational neuroscience (01-06-2010)“…We combine bifurcation analysis with the theory of canard-induced mixed mode oscillations to investigate the dynamics of a novel form of bursting. This…”
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Multiple Timescales, Mixed Mode Oscillations and Canards in Models of Intracellular Calcium Dynamics
Published in Journal of nonlinear science (01-10-2011)“…A range of representative models of intracellular calcium dynamics are surveyed, with the aim of determining which model characteristics are qualitatively…”
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Mixed mode oscillations in a conceptual climate model
Published in Physica. D (01-02-2015)“…Much work has been done on relaxation oscillations and other simple oscillators in conceptual climate models. However, the oscillatory patterns in climate data…”
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Geometric desingularization of degenerate singularities in the presence of fast rotation: A new proof of known results for slow passage through Hopf bifurcations
Published in Indagationes mathematicae (01-12-2016)“…In this article, we present a new, geometric proof of known results for slow passage through Hopf bifurcations (Baer et al. (1989), Neishtadt (1987, 1988),…”
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A geometric understanding of how fast activating potassium channels promote bursting in pituitary cells
Published in Journal of computational neuroscience (01-04-2014)“…The electrical activity of endocrine pituitary cells is mediated by a plethora of ionic currents and establishing the role of a single channel type is…”
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