Search Results - "Webster, Lynn R"

A randomized, placebo-controlled trial of lubiprostone for opioid-induced constipation in chronic noncancer pain by Jamal, M Mazen, Adams, Atoya B, Jansen, Jan-Peter, Webster, Lynn R

“…This multicenter, phase 3 trial evaluated oral lubiprostone for constipation associated with non-methadone opioids in patients with chronic noncancer-related…”
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Discerning suicide in drug intoxication deaths: Paucity and primacy of suicide notes and psychiatric history by Rockett, Ian R H, Caine, Eric D, Connery, Hilary S, D'Onofrio, Gail, Gunnell, David J, Miller, Ted R, Nolte, Kurt B, Kaplan, Mark S, Kapusta, Nestor D, Lilly, Christa L, Nelson, Lewis S, Putnam, Sandra L, Stack, Steven, Värnik, Peeter, Webster, Lynn R, Jia, Haomiao

“…A paucity of corroborative psychological and psychiatric evidence may be inhibiting detection of drug intoxication suicides in the United States. We evaluated…”
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Predicting Aberrant Behaviors in Opioid-Treated Patients: Preliminary Validation of the Opioid Risk Tool by Webster, Lynn R., Webster, Rebecca M.

“…ABSTRACT Objective.  To provide clinicians with a brief screening tool to predict accurately which individuals may develop aberrant behaviors when prescribed…”
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The Physiology and Maintenance of Respiration: A Narrative Review by Webster, Lynn R., Karan, Suzanne

“…Chronic pain is one of the most common reasons adults seek medical care and is often managed with opioid analgesics; however, opioids may cause respiratory…”
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Risk Factors for Opioid-Use Disorder and Overdose by Webster, Lynn R.

“…Opioid analgesics are recognized as a legitimate medical therapy for selected patients with severe chronic pain that does not respond to other therapies…”
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Consensus Recommendations on Initiating Prescription Therapies for Opioid‐Induced Constipation by Argoff, Charles E., Brennan, Michael J., Camilleri, Michael, Davies, Andrew, Fudin, Jeffrey, Galluzzi, Katherine E., Gudin, Jeffrey, Lembo, Anthony, Stanos, Steven P., Webster, Lynn R.

“…Objective Aims of this consensus panel were to determine (1) an optimal symptom‐based method for assessing opioid‐induced constipation in clinical practice and…”
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Pharmacogenetics and Personalized Medicine in Pain Management by Webster, Lynn R., MD, Belfer, Inna, MD, PhD

“…Genetic research heralds a new therapeutic approach to pain management. Increasing literature demonstrates individual genetic vulnerabilities to specific pain…”
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Current Regulations Related to Opioid Prescribing by Webster, Lynn R., MD, Grabois, Martin, MD

“…Abstract It is the responsibility of medical professionals to do all that is possible to safely alleviate pain. Opioids are frequently prescribed for pain but…”
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Chronic Pain and the Opioid Conundrum by Webster, Lynn R., MD

“…Opioids prescribed for chronic cancer and noncancer pain have been embroiled in public policy debates as to effectiveness and potential for contributing to…”
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Intrathecal Gabapentin to Treat Chronic Intractable Noncancer Pain by Rauck, Richard, Coffey, Robert J., Schultz, David M., Wallace, Mark S., Webster, Lynn R., McCarville, Sally E., Grigsby, Eric J., Page, Linda M.

“…BACKGROUND:Oral gabapentin is approved as an anticonvulsant medication and to treat postherpetic neuralgia. Its nonopioid properties and presumed spinal site…”
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Long-Term Safety of NGX-4010, a High-Concentration Capsaicin Patch, in Patients with Peripheral Neuropathic Pain by Simpson, David M., MD, Gazda, Suzanne, MD, Brown, Stephen, MD, Webster, Lynn R., MD, Lu, Shiao-Ping, MS, Tobias, Jeffrey K., MD, Vanhove, Geertrui F., MD, PhD

“…Abstract Context Postherpetic neuralgia (PHN) and painful human immunodeficiency virus-associated distal sensory polyneuropathy (HIV-DSP) are peripheral…”
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Randomized, Double-Blind, Placebo-Controlled Study of the Abuse Potential of Different Formulations of Oral Oxycodone by Webster, Lynn R., Bath, Brad, Medve, Robert A., Marmon, Tonya, Stoddard, Gregory J.

“…Objective.  The objective of this study was to evaluate the pharmacokinetics and abuse potential of different formulations of oxycodone. Design.  The…”
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Intranasal Pharmacokinetics of Morphine ARER, a Novel Abuse-Deterrent Formulation: Results from a Randomized, Double-Blind, Four-Way Crossover Study in Nondependent, Opioid-Experienced Subjects by Kinzler, Eric R., Smith, Michael D., Iverson, Matthew, Pantaleon, Carmela, Webster, Lynn R., Aigner, Stefan

“…Objective. To investigate the pharmacokinetics (PK) of Morphine ARER, an extended-release (ER), abuse-deterrent formulation of morphine sulfate after oral and…”
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Long-Term Intrathecal Ziconotide for Chronic Pain: An Open-Label Study by Webster, Lynn R., MD, Fisher, Robert, MD, Charapata, Steven, MD, Wallace, Mark S., MD

“…Abstract This open-label multicenter study evaluated the long-term safety and efficacy of intrathecal ziconotide and included 78 patients with chronic pain who…”
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Effects of intravenous oxycodone alone or in combination with naltrexone on measures of respiratory depression: a randomized placebo-controlled study by Bass, Almasa, Webster, Lynn R, Matschke, Kyle T, Malhotra, Bimal K, Wolfram, Gernot

“…Abuse of prescription opioids, particularly by intravenous (IV) administration, can cause respiratory depression and death. ALO-02, an abuse-deterrent opioid…”
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Long-Term Safety and Efficacy of Morphine Sulfate and Naltrexone Hydrochloride Extended Release Capsules, a Novel Formulation Containing Morphine and Sequestered Naltrexone, in Patients with Chronic, Moderate to Severe Pain by Webster, Lynn R., MD, Brewer, Randall, MD, Wang, Chao, PhD, Sekora, Doreen, MPH, Johnson, Franklin K., MS, Morris, David, PhD, Stauffer, Joseph, DO, MBA

“…Abstract Context Morphine sulfate and naltrexone hydrochloride extended release capsules contain extended-release pellets of morphine with a sequestered…”
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Opioid‐Induced Constipation by Webster, Lynn R.

“…Introduction Opioid‐induced constipation (OIC) is common in people treated with opioids and poses risks for physical sequelae, analgesic discontinuation, and…”
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The Relationship Between the Mechanisms of Action and Safety Profiles of Intrathecal Morphine and Ziconotide: A Review of the Literature by Webster, Lynn R.

“…Objective To better characterize safety profiles associated with the intrathecal (IT) administration of morphine and ziconotide and discuss how they relate to…”
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Long-term use of naldemedine in the treatment of opioid-induced constipation in patients with chronic noncancer pain: a randomized, double-blind, placebo-controlled phase 3 study by Webster, Lynn R., Nalamachu, Srinivas, Morlion, Bart, Reddy, Jyotsna, Baba, Yuko, Yamada, Tadaaki, Arjona Ferreira, Juan C.

“…The long-term safety of naldemedine, a peripherally acting µ-opioid receptor antagonist, was evaluated in patients with opioid-induced constipation and chronic…”
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Uncritical Publication of a Biased Study Leads to Misleading Media Reports by Webster, Lynn R

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