Search Results - "Webster, Luke P."

API Continuous Cooling and Antisolvent Crystallization for Kinetic Impurity Rejection in cGMP Manufacturing by Johnson, Martin D, Burcham, Christopher L, May, Scott A, Calvin, Joel R, McClary Groh, Jennifer, Myers, Steven S, Webster, Luke P, Roberts, Jeffrey C, Reddy, Venkata Ramana, Luciani, Carla V, Corrigan, Aoife P, Spencer, Richard D, Moylan, Robert, Boyse, Raymond, Murphy, John D, Stout, James R

“…Crystallization of 204 kg of final active pharmaceutical ingredient was accomplished continuously using a cascade of mixed suspension mixed product removal…”
Get full text

Flow Grignard and Lithiation: Screening Tools and Development of Continuous Processes for a Benzyl Alcohol Starting Material by Kopach, Michael E, Cole, Kevin P, Pollock, Patrick M, Johnson, Martin D, Braden, Timothy M, Webster, Luke P, McClary Groh, Jennifer, McFarland, Adam D, Schafer, John P, Adler, Jonathan J, Rosemeyer, Morgan

“…Efficient continuous Grignard and lithiation processes were developed to produce one of the key regulatory starting materials for the production of edivoxetine…”
Get full text

Development of Universal, Automated Sample Acquisition, Preparation, and Delivery Devices and Methods for Pharmaceutical Applications by Lambertus, Gordon R, Webster, Luke P, Braden, Timothy M, Campbell, Bradley M, McClary Groh, Jennifer, Maloney, Todd D, Milenbaugh, Paul, Spencer, Richard D, Sun, Wei-ming, Johnson, Martin D

“…Continued emphasis in the pharmaceutical industry toward development of hybrid and continuous processes has led to a resurgence in process analytical…”
Get full text

Continuous GMP Manufacturing for Grignard Reagent/Zincate Synthesis and Negishi Coupling Reaction by Calvin, Joel R., Boyse, Raymond, Braden, Timothy M., Brewer, Alison C., Changi, Shujauddin, Harrold, Donal, Johnson, Martin, Kerr, Mark S., Lambertus, Gordon R., Luciani, Carla V., May, Scott A., Moloney, Harold, Murphy, John D., Roberts, Jeffrey C., Schafer, John P., Spencer, Richard D., Webster, Luke P.

“…A synthetic route to API was designed containing a Negishi cross-coupling reaction, where the zincate reagent was generated by transmetalation of a Grignard…”
Get full text