Search Results - "Webster, Lorraine K"

Systematic differences in electrochemical reduction of the structurally characterized anti-cancer platinum(IV) complexes [Pt{((p-HC6F4)NCH2)2}-(pyridine)2Cl2], [Pt{((p-HC6F4)NCH2)2}(pyridine)2(OH)2], and [Pt{((p-HC6F4)NCH2)2}(pyridine)2(OH)Cl] by Guo, Si-Xuan, Mason, Dayna N., Turland, Susan A., Lawrenz, Eric T., Kelly, Lance C., Fallon, Gary D., Gatehouse, Bryan M., Bond, Alan M., Deacon, Glen B., Battle, Andrew R., Hambley, Trevor W., Rainone, Silvina, Webster, Lorraine K., Cullinane, Carleen

“…The putative platinum(IV) anticancer drugs, [Pt{((R)NCH2)2}(py)2XY] (X,Y=Cl, R=p-HC6F4 (1a), C6F5 (1b); X,Y=OH, R=p-HC6F4 (2); X=Cl, Y=OH, R=p-HC6F4 (3), py =…”
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The direct mapping of the uptake of platinum anticancer agents in individual human ovarian adenocarcinoma cells using a hard X-ray microprobe by ILINSKI, Petr, LAI, Barry, PHILLIPS, Don R, STAMPFL, Anton P. J, ZHONGHOU CAI, WENBING YUN, LEGNINI, Daniel, TALARICO, Teresa, CHOLEWA, Marian, WEBSTER, Lorraine K, DEACON, Glen B, RAINONE, Silvina

“…Uptake of platinum-based anticancer compounds into individual human ovarian andenocarcinoma cells was measured using an X-ray microprobe. The uptake of…”
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Preparation and cell growth inhibitory activity of [PtR 2L 2] (R=polyfluorophenyl, L 2=diene, cyclohexane-1,2-diamine (chxn) or cis-(dimethyl sulfoxide) 2) and the X-ray crystal structure of [Pt(C 6F 5) 2( cis-chxn)] by Cullinane, Carleen, Deacon, Glen B, Drago, Penny R, Hambley, Trevor W, Nelson, Keith T, Webster, Lorraine K

“…A range of [PtR 2(chxn)] (R=C 6F 5, o-HC 6F 4, p-HC 6F 4, p-MeOC 6F 4 or 3,5-H 2C 6F 3; chxn=cyclohexane-1,2-diamine) and cis-[PtR 2(dmso) 2] (R=C 6F 5, p-HC…”
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A randomized cross-over trial to determine the effect of Cremophor EL on the pharmacodynamics and pharmacokinetics of carboplatin chemotherapy by LOI, Sherene, RISCHIN, Danny, MICHAEL, Michael, YUEN, Kally, STOKES, Kerrie H, ELLIS, Andrew G, MILLWARD, Michael J, WEBSTER, Lorraine K

“…Paclitaxel, when combined with carboplatin, exhibits a platelet-sparing effect. Paclitaxel is formulated in Cremophor EL (CrEL), which has been shown in…”
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Atypical pharmacokinetics and excretion of new platinum analogues in rodents by WEBSTER, Lorraine K, ELLIS, Andrew G, APICELLA, Carmel, DEACON, Glen B

“…Two new series of platinum complexes with cytotoxic activity in vivo are [Pt(NRCH2)2L2], (R=polyfluorophenyl, L=pyridine or substituted pyridine) and…”
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Cremophor Pharmacokinetics in Patients Receiving 3-, 6-, and 24-Hour Infusions of Paclitaxel by Rischin, Danny, Webster, Lorraine K., Millward, Michael J., Linahan, Bernadette M., Toner, Guy C., Woollett, Anne M., Morton, Carmel G., Bishop, James F.

“…Background Paclitaxel (Taxol) is a new drug with efficacy against a variety of malignant tumors. The clinical formulation of paclitaxel contains 50% Cremophor…”
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Activity and DNA binding of new organoamidoplatinum (II) complexes by TALARICO, T, PHILLIPS, D. R, DEACON, G. B, RAINONE, S, WEBSTER, L. K

“…Two series of organoamidoplatinum (II) complexes were synthesized [Class 1, Pt(NRCH2)2L2 and Class 2, Pt(NRCH2CH2NR2')L(X)] and their antitumour activity…”
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Synthesis, cytotoxicity, cell uptake and DNA interstrand cross-linking of 4,4'-dipyrazolylmethane-linked multinuclear platinum anti-cancer complexes by Wheate, N J, Cullinane, C, Webster, L K, Collins, J G

“…Two cationic multinuclear platinum complexes linked with the 4,4'-dipyrazolylmethane (dpzm) ligand, trans-[[Pt(NH3)2Cl]2-mu-dpzm]Cl2 (di-Pt) and…”
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Preparation, characterization, cytotoxicity, and mutagenicity of a pair of enantiomeric platinum(II) complexes with the potential to bind enantioselectively to DNA by Vickery, Kymberley, Bonin, Antonio M, Fenton, Ronald R, O'Mara, Shaun, Russell, Pamela J, Webster, Lorraine K, Hambley, Trevor W

“…The synthesis of a pair of enantiomeric Pt(II) complexes, [Pt(R,R-eap)Cl2] and [Pt(S,S-eap)Cl2] (eap = N,N-diethyl-2,4-pentanediamine), designed to bind…”
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cis-Bis(pyridine)platinum(II) organoamides with unexpected growth inhibition properties and antitumor activity by Webster, Lorraine K, Deacon, Glen B, Buxton, David P, Hillcoat, Brian L, James, Alison M, Roos, Ian A. G, Thomson, Robin J, Wakelin, Laurence P. G, Williams, Tracey L

“…The platinum(II) organoamides [Pt(NRCH2)2L2] (L = pyridine (py), R = p-HC6F4, C6F5,p-IC6F4,p-CIC6F4,p-C6F5C6F4; L = 4-methylpyridine, R = p-HC6F4) and…”
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A phase I and pharmacokinetic study of paclitaxel and epirubicin in advanced cancer by RISCHIN, D, WEBSTER, L. K, MILLWARD, M. J, TONER, G. C, NAWARATNE, S, GANJU, V, FRANCIS, P, BISHOP, J. F

“…The objectives of this phase I trial were to determine the maximally tolerated doses of the combination of epirubicin and paclitaxel with and without G-CSF…”
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Nuclear and mitochondrial distribution of organoamidoplatinum(II) lesions in cisplatin-sensitive and -resistant adenocarcinoma cells by Talarico, T, Cullinane, C M, Gray, P J, Webster, L K, Deacon, G B, Phillips, D R

“…The DNA binding pattern of the organoamidoplatinum(II) compound 1a is of considerable interest because of its known activity against cisplatin-resistant cells…”
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Effect of trimethoprim, paracetamol and cimetidine on trimetrexate metabolism by rat perfused isolated livers by Webster, L K, Tong, W P, McCormack, J J

“…Trimetrexate (TMTX), a non-classical antifolate, is currently in clinical trial as an antineoplastic drug. In the rat perfused isolated liver, it undergoes…”
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Effect of omeprazole and polyethylene glycol-400 on antipyrine elimination by the isolated perfused rat liver by Webster, L K, Jones, D B, Mihaly, G W, Smallwood, R A

“…The effect of the substituted benzimidazole, omeprazole, a potent inhibitor of gastric acid secretion, on the hepatic elimination of antipyrine was studied in…”
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Optimal sampling strategies for bayesian estimation of docetaxel (Taxotere) clearance by BAILLE, P, BRUNO, R, SCHELLENS, J. H. M, WEBSTER, L. K, MILLWARD, M, VERWEIJ, J, MONTAY, G

“…Docetaxel activity has been documented in many solid tumors, including metastatic breast cancer and non-small cell lung cancer. However, as clinical studies in…”
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Preparation and cell growth inhibitory activity of [PtR(2)L(2)] (R=polyfluorophenyl, L(2)=diene, cyclohexane-1,2-diamine (chxn) or cis-(dimethyl sulfoxide)(2)) and the X-ray crystal structure of [Pt(C(6)F(5))(2)(cis-chxn)] by Cullinane, Carleen, Deacon, Glen B, Drago, Penny R, Hambley, Trevor W, Nelson, Keith T, Webster, Lorraine K

“…A range of [PtR(2)(chxn)] (R=C(6)F(5), o-HC(6)F(4), p-HC(6)F(4), p-MeOC(6)F(4) or 3,5-H(2)C(6)F(3); chxn=cyclohexane-1,2-diamine) and cis-[PtR(2)(dmso)(2)]…”
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Inhibition of etoposide elimination in the isolated perfused rat liver by Cremophor EL and Tween 80 by ELLIS, A. G, CRINIS, N. A, WEBSTER, L. K

“…Cremophor EL, a surfactant used in the clinical formulation of cyclosporine and paclitaxel, will reverse the multidrug resistance (MDR) phenotype in vitro. As…”
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Phase I trial of cremophor EL with bolus doxorubicin by MILLWARD, M. J, WEBSTER, L. K, RISCHIN, D, STOKES, K. H, TONER, G. C, BISHOP, J. F, OLVER, I. N, LINAHAN, B. M, LINSENMEYER, M. E, WOODCOCK, D. M

“…Cremophor EL (cremophor), a component of the paclitaxel formulation, can potentially reverse P-glycoprotein-associated multidrug resistance. A Phase I trial of…”
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A pharmacokinetic and phase II study of gallium nitrate in patients with non-small cell lung cancer by WEBSTER, L. K, OLVER, I. N, STOKES, K. H, SEPHTON, R. G, HILLCOAT, B. L, BISHOP, J. F

“…This study investigated the pharmacokinetics and activity of gallium nitrate in non-small cell lung cancer when 700 mg/m2 was given as a 30-min infusion with…”
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Plasma concentrations of polysorbate 80 measured in patients following administration of docetaxel or etoposide by WEBSTER, L. K, LINSENMEYER, M. E, RISCHIN, D, URCH, M. E, WOODCOCK, D. M, MILLWARD, M. J

“…Docetaxel (Taxotere, Rhone-Poulenc Rorer) and etoposide are water-insoluble drugs formulated with polysorbate 80 for intravenous administration. We have…”
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