Search Results - "Webster, Alexandre"

The piRNA Pathway Guards the Germline Genome Against Transposable Elements by Tóth, Katalin Fejes, Pezic, Dubravka, Stuwe, Evelyn, Webster, Alexandre

“…Transposable elements (TEs) have the capacity to replicate and insert into new genomic locations. This contributs significantly to evolution of genomes, but…”
Get more information

Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state by Le Thomas, Adrien, Rogers, Alicia K, Webster, Alexandre, Marinov, Georgi K, Liao, Susan E, Perkins, Edward M, Hur, Junho K, Aravin, Alexei A, Tóth, Katalin Fejes

“…In the metazoan germline, piwi proteins and associated piwi-interacting RNAs (piRNAs) provide a defense system against the expression of transposable elements…”
Get full text

Aub and Ago3 Are Recruited to Nuage through Two Mechanisms to Form a Ping-Pong Complex Assembled by Krimper by Webster, Alexandre, Li, Sisi, Hur, Junho K., Wachsmuth, Malte, Bois, Justin S., Perkins, Edward M., Patel, Dinshaw J., Aravin, Alexei A.

“…In Drosophila, two Piwi proteins, Aubergine (Aub) and Argonaute-3 (Ago3), localize to perinuclear “nuage” granules and use guide piRNAs to target and destroy…”
Get full text

Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex by Huang, Xiawei, Hu, Hongmiao, Webster, Alexandre, Zou, Fan, Du, Jiamu, Patel, Dinshaw J., Sachidanandam, Ravi, Toth, Katalin Fejes, Aravin, Alexei A., Li, Sisi

“…PIWI proteins use guide piRNAs to repress selfish genomic elements, protecting the genomic integrity of gametes and ensuring the fertility of animal species…”
Get full text

Mechanisms of Aneuploidy in Human Eggs by Webster, Alexandre, Schuh, Melina

“…Eggs and sperm develop through a specialized cell division called meiosis. During meiosis, the number of chromosomes is reduced by two sequential divisions in…”
Get full text

Aneuploidy in mammalian oocytes and the impact of maternal ageing by Charalambous, Chloe, Webster, Alexandre, Schuh, Melina

“…During fertilization, the egg and the sperm are supposed to contribute precisely one copy of each chromosome to the embryo. However, human eggs frequently…”
Get full text

Cryosectioning fixed and cryoprotected biological material for immunocytochemistry by Webster, Paul, Webster, Alexandre

“…Immunocytochemistry for transmission electron microscopy provides important information on the location and relative abundance of proteins inside cells…”
Get more information

Mechanisms of Transposable Element Repression by Piwi Proteins in the piRNA Pathway of Drosophila Germ Cells by Webster, Alexandre

“…The ability to reproduce is a defining characteristic of all living organisms. During reproduction, the integrity of genetic material transferred from one…”
Get full text

Cryosectioning fixed and cryoprotected biological material for immunocytochemistry by Webster, Paul, Webster, Alexandre

“…Immunocytochemistry for electron microscopy provides important information on the location and relative abundance of proteins inside cells. Gaining access to…”
Get more information

A dimeric form of the HIV-1 antibody 2G12 elicits potent antibody-dependent cellular cytotoxicity by KLEIN, Joshua S, WEBSTER, Alexandre, GNANAPRAGASAM, Priyanthi N. P, GALIMIDI, Rachel P, BJORKMAN, Pamela J

“…Increasing data support a role for antibody-dependent cellular cytotoxicity (ADCC) in controlling HIV-1 infection. We recently isolated a naturally occurring…”
Get full text

Mechanisms of Transposable Element Repression by Piwi Proteins in the piRNA Pathway of Drosophila Germ Cells by Webster, Alexandre

“…The ability to reproduce is a defining characteristic of all living organisms. During reproduction, the integrity of genetic material transferred from one…”
Get full text