Rabbit and Mouse Models of HSV-1 Latency, Reactivation, and Recurrent Eye Diseases

The exact mechanisms of HSV-1 establishment, maintenance, latency, reactivation, and also the courses of recurrent ocular infections remain a mystery. Comprehensive understanding of the HSV-1 disease process could lead to prevention of HSV-1 acute infection, reactivation, and more effective treatmen...

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Bibliographic Details
Published in:	Journal of biomedicine & biotechnology Vol. 2012; no. 2012; pp. 1 - 18
Main Authors:	Webre, Jody M., Hill, James M., Nolan, Nicole M., Clement, Christian, McFerrin, Harris E., Bhattacharjee, Partha S., Hsia, Victor, Neumann, Donna M., Foster, Timothy P., Lukiw, Walter J., Thompson, Hilary W.
Format:	Journal Article
Language:	English
Published:	Cairo, Egypt Hindawi Puplishing Corporation 01-01-2012 Hindawi Publishing Corporation John Wiley & Sons, Inc
Subjects:	Animals Disease Models, Animal Eye diseases Eye Infections, Viral - physiopathology Eye Infections, Viral - virology Health aspects Herpes Simplex - physiopathology Herpes Simplex - virology Herpes simplex virus 1 Herpesvirus 1, Human - physiology Humans Infection Rabbits Recurrence Review Species Specificity Virus Activation - physiology Virus Latency - physiology Louisiana
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Summary:	The exact mechanisms of HSV-1 establishment, maintenance, latency, reactivation, and also the courses of recurrent ocular infections remain a mystery. Comprehensive understanding of the HSV-1 disease process could lead to prevention of HSV-1 acute infection, reactivation, and more effective treatments of recurrent ocular disease. Animal models have been used for over sixty years to investigate our concepts and hypotheses of HSV-1 diseases. In this paper we present descriptions and examples of rabbit and mouse eye models of HSV-1 latency, reactivation, and recurrent diseases. We summarize studies in animal models of spontaneous and induced HSV-1 reactivation and recurrent disease. Numerous stimuli that induce reactivation in mice and rabbits are described, as well as factors that inhibit viral reactivation from latency. The key features, advantages, and disadvantages of the mouse and rabbit models in relation to the study of ocular HSV-1 are discussed. This paper is pertinent but not intended to be all inclusive. We will give examples of key papers that have reported novel discoveries related to the review topics.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 Academic Editor: Andre Van Wijnen
ISSN:	1110-7243 1110-7251 1110-7251
DOI:	10.1155/2012/612316