Search Results - "Weber, Valerie"

Open Notes: Doctors and Patients Signing On by DELBANCO, Tom, WALKER, Jan, DARER, Jonathan D, ELMORE, Joann G, FELDMAN, Henry J, LEVEILLE, Suzanne G, RALSTON, James D, ROSS, Stephen E, VODICKA, Elisabeth, WEBER, Valerie D

“…Few patients read their doctors' notes, despite having the legal right to do so. As information technology makes medical records more accessible and society…”
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First Into the Lifeboats: Protecting Medical Student Education During the Hahnemann University Hospital Closure by Weber, Valerie D., Farabaugh, Dana C., Fuchs, Amy C., Smith, Robin C., Kocsis, Jenna E.

“…The announcement of the closure of Philadelphia’s Hahnemann University Hospital in June 2019 sent shock waves through the academic community. The closure had a…”
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An Electronic Medical Record (EMR)-Based Intervention to Reduce Polypharmacy and Falls in an Ambulatory Rural Elderly Population by Weber, Valerie, White, Alan, McIlvried, Robb

“…Background Falls are the leading cause of injury-related deaths in the aging population. Electronic medical record (EMR) systems can identify at-risk patients…”
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Novel Radioiodinated and Radiofluorinated Analogues of FT-2102 for SPECT or PET Imaging of mIDH1 Mutant Tumours by Weber, Valérie, Arnaud, Lucie, Dukic-Stefanovic, Sladjana, Wenzel, Barbara, Roux, Valérie, Chezal, Jean-Michel, Lai, Thu-Hang, Teodoro, Rodrigo, Kopka, Klaus, Miot-Noirault, Elisabeth, Deuther-Conrad, Winnie, Maisonial-Besset, Aurélie

“…Isocitrate dehydrogenases (IDHs) are metabolic enzymes commonly mutated in human cancers (glioma, acute myeloid leukaemia, chondrosarcoma, and intrahepatic…”
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Menopause FAQs (Faqs series) by Weber, Valerie

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Radiosynthesis and biological evaluation of [18F]AG-120 for PET imaging of the mutant isocitrate dehydrogenase 1 in glioma by Lai, Thu Hang, Wenzel, Barbara, Dukić-Stefanović, Sladjana, Teodoro, Rodrigo, Arnaud, Lucie, Maisonial-Besset, Aurélie, Weber, Valérie, Moldovan, Rareş-Petru, Meister, Sebastian, Pietzsch, Jens, Kopka, Klaus, Juratli, Tareq A., Deuther-Conrad, Winnie, Toussaint, Magali

“…Glioma are clinically challenging tumors due to their location and invasiveness nature, which often hinder complete surgical resection. The evaluation of the…”
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Structure-activity relationship study of hypoxia-activated prodrugs for proteoglycan-targeted chemotherapy in chondrosarcoma by Ghedira, Donia, Voissière, Aurélien, Peyrode, Caroline, Kraiem, Jamil, Gerard, Yvain, Maubert, Elise, Vivier, Magali, Miot-Noirault, Elisabeth, Chezal, Jean-Michel, Farhat, Farhat, Weber, Valérie

“…Due to an abundant chondrogenic, poorly vascularized and particularly hypoxic extracellular matrix, chondrosarcoma, a malignant cartilaginous tumour, is chemo-…”
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Proteoglycan-targeting applied to hypoxia-activated prodrug therapy in chondrosarcoma: first proof-of-concept by Voissiere, Aurélien, Weber, Valérie, Gerard, Yvain, Rédini, Françoise, Raes, Florian, Chezal, Jean-Michel, Degoul, Françoise, Peyrode, Caroline, Miot-Noirault, Elisabeth

“…Due to its abundant chondrogenic matrix and hypoxic tissue, chondrosarcoma is chemo- and radio-resistant. Our group has developed a proteoglycan targeting…”
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Relevance of the combination of external beam radiotherapy with the hypoxia-activated prodrug ICF05016 in an experimental model of extraskeletal myxoid chondrosarcoma by Maubert, Elise, Weber, Valérie, Voissière, Aurélien, Gérard, Yvain, Dedieu, Véronique, Degoul, Françoise, Chezal, Jean-Michel, Chautard, Emmanuel, Miot-Noirault, Elisabeth

“…Summary Currently, there is no gold standard treatment for Extraskeletal Myxoid Chondrosarcomas (EMC) making wide margin surgical resection the most effective…”
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PS1-06: Increased Incident Renal Disease with ACE-1 + Thiazide Therapy for Hypertension: The Geisinger Clinic Population by Langer, R. D, Graham, J., Hennessy, S., Townsend, R. R, Weber, V., Bloom, F.

“…Background and Aims: Thiazide diuretics are recommended alone or in combination for uncomplicated hypertension (HTN). Most patients require treatment with 2 or…”
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C-D2-01: Outcomes Associated With Thiazide Combinations for Second-line Treatment of Hypertension in Older Patients by Langer, R. D, Graham, J., Hennessy, S., Townsend, R. R, Bloom, F., Weber, V.

“…Context: Consensus guidelines recommend thiazides for first-line treatment in uncomplicated hypertension. Most patients require two or more drugs and little is…”
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Linker structure-activity relationships in fluorodeoxyglucose chlorambucil conjugates for tumor-targeted chemotherapy by El Hilali, Mostafa, Reux, Bastien, Debiton, Eric, Leal, Fernand, Galmier, Marie-Josephe, Vivier, Magali, Chezal, Jean-Michel, Miot-Noirault, Elisabeth, Coudert, Pascal, Weber, Valérie

“…Pharmacomodulation of the linker tethered the FDG tumor-seeking group and the alkylating N-mustard leads to compound 51, identified as the most active FDG-CLB…”
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Design, synthesis and evaluation of targeted hypoxia-activated prodrugs applied to chondrosarcoma chemotherapy by Gerard, Yvain, Voissière, Aurélien, Peyrode, Caroline, Galmier, Marie-Josephe, Maubert, Elise, Ghedira, Donia, Tarrit, Sebastien, Gaumet, Vincent, Canitrot, Damien, Miot-Noirault, Elisabeth, Chezal, Jean-Michel, Weber, Valérie

“…Part 2. Hypoxia-activated prodrug with a quaternary ammonium function as proteoglycan-targeting ligand for a better management of chondrosarcoma: synthesis,…”
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First Into the Lifeboats: Protecting Medical Student Education During the Hahnemann University Hospital Closure by Weber, Valerie D., Farabaugh, Dana C., Fuchs, Amy C., Smith, Robin C., Kocsis, Jenna E.

“…The announcement of the closure of Philadelphia’s Hahnemann University Hospital in June 2019 sent shock waves through the academic community. The closure had a…”
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Employing the Electronic Health Record to Improve Diabetes Care: A Multifaceted Intervention in an Integrated Delivery System by Weber, Valerie, Bloom, Frederick, Pierdon, Steve, Wood, Craig

“…INTRODUCTION Type 2 diabetes is one of the nation’s most prevalent chronic diseases. Although well-known practice guidelines exist, real-life clinical…”
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Proteoglycans as Target for an Innovative Therapeutic Approach in Chondrosarcoma: Preclinical Proof of Concept by Peyrode, Caroline, Weber, Valérie, Voissière, Aurélien, Maisonial-Besset, Aurélie, Vidal, Aurélien, Auzeloux, Philippe, Gaumet, Vincent, Borel, Michèle, Dauplat, Marie-Mélanie, Quintana, Mercedes, Degoul, Françoise, Rédini, Françoise, Chezal, Jean-Michel, Miot-Noirault, Elisabeth

“…To date, surgery remains the only option for the treatment of chondrosarcoma, which is radio- and chemoresistant due in part to its large extracellular matrix…”
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Drexel University College of Medicine by Baranoski, Amy S., Russo, Donna M., Weber, Valerie

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Synthesis and cytotoxic properties of new fluorodeoxyglucose-coupled chlorambucil derivatives by Reux, Bastien, Weber, Valérie, Galmier, Marie-Josephe, Borel, Michèle, Madesclaire, Michel, Madelmont, Jean-Claude, Debiton, Eric, Coudert, Pascal

“…The synthesis and in vitro cytotoxicity of new fluoroglucoconjugates in which chlorambucil is attached to the C-1 position of the FDG skeleton using a variety…”
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Quaternary ammonium-melphalan conjugate for anticancer therapy of chondrosarcoma: in vitro and in vivo preclinical studies by Peyrode, Caroline, Weber, Valérie, David, Emmanuelle, Vidal, Aurélien, Auzeloux, Philippe, Communal, Yves, Dauplat, Marie Mélanie, Besse, Sophie, Gouin, François, Heymann, Dominique, Chezal, Jean Michel, Rédini, François, Miot-Noirault, Elisabeth

“…Summary Cartilage tumours present ongoing therapeutic challenges due to their chondrogenic extracellular matrix that potentially hampers drug delivery, their…”
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Preclinical investigation of tolerance and antitumour activity of new fluorodeoxyglucose-coupled chlorambucil alkylating agents by Miot-Noirault, Elisabeth, Reux, Bastien, Debiton, Eric, Madelmont, Jean-Claude, Chezal, Jean-Michel, Coudert, Pascal, Weber, Valérie

“…Summary Our strategy is to increase drug accumulation in target tumour cells using specific “vectors” tailored to neoplastic tissue characteristics, which…”
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