Search Results - "Weber, Michael H W"

Are humanized IgE reporter systems potential game changers in serological diagnosis of human parasitic infection? by Prakash, Prema S., Weber, Michael H. W., van Hellemond, Jaap J., Falcone, Franco H.

“…Immunoglobulin E (IgE) is thought to have evolved to protect mammalian hosts against parasitic infections or toxins and plays a central role in the…”
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Impact of rRNA methylations on ribosome recycling and fidelity of initiation in Escherichia coli by Seshadri, Anuradha, Dubey, Badrinath, Weber, Michael H.W, Varshney, Umesh

“…Ribosomal RNA (rRNA) contains a number of modified nucleosides in functionally important regions including the intersubunit bridge regions. As the activity of…”
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The Humanised NPY-mRFP RBL Reporter Cell Line Is a Fast and Inexpensive Tool for Detection of Allergen-Specific IgE in Human Sera by Prakash, Prema S, Barwary, Nafal J. S, Weber, Michael H. W, Wan, Daniel, Conejeros, Iván, Pereira Moreira, Bernardo, Alharbi, Waleed S, van Hellemond, Jaap J, Akinwale, Jude, Falcone, Franco H

“…Rat basophilic leukaemia (RBL) cells have been used for decades as a model of high-affinity Immunoglobulin E (IgE) receptor (FcεRI) signalling. Here, we…”
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Role of the Ribosomal P-Site Elements of m2G966, m5C967, and the S9 C-Terminal Tail in Maintenance of the Reading Frame during Translational Elongation in Escherichia coli by Arora, Smriti, Bhamidimarri, Satya Prathyusha, Weber, Michael H. W, Varshney, Umesh

“…The ribosomal P-site hosts the peptidyl-tRNAs during translation elongation. Which P-site elements support these tRNA species to maintain codon-anticodon…”
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Drug Repurposing and De Novo Drug Discovery of Protein Kinase Inhibitors as New Drugs against Schistosomiasis by Pereira Moreira, Bernardo, Weber, Michael H W, Haeberlein, Simone, Mokosch, Annika S, Spengler, Bernhard, Grevelding, Christoph G, Falcone, Franco H

“…Schistosomiasis is a neglected tropical disease affecting more than 200 million people worldwide. Chemotherapy relies on one single drug, praziquantel, which…”
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Northern blot detection of endogenous small RNAs (~14 nt) in bacterial total RNA extracts by Beckmann, Benedikt M, Grünweller, Arnold, Weber, Michael H.W, Hartmann, Roland K

“…Here we describe a northern blot procedure that allows the detection of endogenous RNAs as small as ~14 nt in total RNA extracts from bacteria. RNAs that small…”
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Genomewide Transcriptional Analysis of the Cold Shock Response in Bacillus subtilis by Beckering, Carsten L., Steil, Leif, Weber, Michael H. W., Völker, Uwe, Marahiel, Mohamed A.

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Cold Shock Response of Bacillus subtilis: Isoleucine-Dependent Switch in the Fatty Acid Branching Pattern for Membrane Adaptation to Low Temperatures by Klein, W, Weber, M H, Marahiel, M A

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Coping with the cold: the cold shock response in the Gram-positive soil bacterium Bacillus subtilis by Weber, Michael H. W., Marahiel, Mohamed A.

“…All organisms examined to date, respond to a sudden change in environmental temperature with a specific cascade of adaptation reactions that, in some cases,…”
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Investigation of catalysis by bacterial RNase P via LNA and other modifications at the scissile phosphodiester by Cuzic-Feltens, Simona, Weber, Michael H.W, Hartmann, Roland K

“…We analyzed cleavage of precursor tRNAs with an LNA, 2'-OCH₃, 2'-H or 2'-F modification at the canonical (c₀) site by bacterial RNase P. We infer that the…”
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Identification and characterisation of the tegument-expressed aldehyde dehydrogenase SmALDH_312 of Schistosoma mansoni, a target of disulfiram by Beutler, Mandy, Harnischfeger, Julie, Weber, Michael H.W., Hahnel, Steffen R., Quack, Thomas, Blohm, Ariane, Ueberall, Monique E., Timm, Thomas, Lochnit, Günter, Rennar, Georg A., Gallinger, Tom L., Houhou, Hicham, Rahlfs, Stefan, Falcone, Franco H., Becker, Katja, Schlitzer, Martin, Haeberlein, Simone, Czermak, Peter, Salzig, Denise, Grevelding, Christoph G.

“…Schistosomiasis is an infectious disease caused by blood flukes of the genus Schistosoma and affects approximately 200 million people worldwide. Since…”
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Complementation of Cold Shock Proteins by Translation Initiation Factor IF1 In Vivo by Weber, M H, Beckering, C L, Marahiel, M A

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Identification of potent schistosomicidal compounds predicted as type II-kinase inhibitors against Schistosoma mansoni c-Jun N-terminal kinase SMJNK by Moreira, Bernardo P., Gava, Sandra G., Haeberlein, Simone, Gueye, Sophie, Santos, Ester S. S., Weber, Michael H. W., Abramyan, Tigran M., Grevelding, Christoph G., Mourão, Marina M., Falcone, Franco H.

“…Introduction Schistosomiasis has for many years relied on a single drug, praziquantel (PZQ) for treatment of the disease. Immense efforts have been invested in…”
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Phenotypic characterization and complementation analysis of Bacillus subtilis 6S RNA single and double deletion mutants by Hoch, Philipp G., Burenina, Olga Y., Weber, Michael H.W., Elkina, Daria A., Nesterchuk, Mikhail V., Sergiev, Petr V., Hartmann, Roland K., Kubareva, Elena A.

“…6S RNA, a global regulator of transcription in bacteria, binds to housekeeping RNA polymerase (RNAP) holoenzymes to competitively inhibit transcription from…”
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Biochemical Characterization of Pathogenic Mutations in Human Mitochondrial Methionyl-tRNA Formyltransferase by Sinha, Akesh, Köhrer, Caroline, Weber, Michael H.W., Masuda, Isao, Mootha, Vamsi K., Hou, Ya-Ming, RajBhandary, Uttam L.

“…N-Formylation of initiator methionyl-tRNA (Met-tRNAMet) by methionyl-tRNA formyltransferase (MTF) is important for translation initiation in bacteria,…”
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Localization of Cold Shock Proteins to Cytosolic Spaces Surrounding Nucleoids in Bacillus subtilis Depends on Active Transcription by Weber, M H, Volkov, A V, Fricke, I, Marahiel, M A, Graumann, P L

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Distinctive contributions of the ribosomal P-site elements m2G966, m5C967 and the C-terminal tail of the S9 protein in the fidelity of initiation of translation in Escherichia coli by Arora, Smriti, Bhamidimarri, Satya Prathyusha, Bhattacharyya, Moitrayee, Govindan, Ashwin, Weber, Michael H W, Vishveshwara, Saraswathi, Varshney, Umesh

“…The accuracy of pairing of the anticodon of the initiator tRNA (tRNA(fMet)) and the initiation codon of an mRNA, in the ribosomal P-site, is crucial for…”
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Bacterial cold shock responses by WEBER, MICHAEL H. W., MARAHIEL, MOHAMED A.

“…As a measure for molecular motion, temperature is one of the most important environmental factors for life as it directly influences structural and hence…”
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CSDBase: an interactive database for cold shock domain-containing proteins and the bacterial cold shock response by Weber, Michael H W, Fricke, Ingo, Doll, Niclas, Marahiel, Mohamed A

“…CSDBase (http://www.chemie.uni-marburg.de/~csdbase/) is an interactive Internet-embedded research platform providing detailed information on proteins…”
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Role of the Bacillus subtilis fatty acid desaturase in membrane adaptation during cold shock by Weber, Michael H. W., Klein, Wolfgang, Müller, Lin, Niess, Ulf M., Marahiel, Mohamed A.

“…In our attempt to understand the cold shock response of Bacillus subtilis, we report on the role of the B. subtilis fatty acid desaturase (FA‐D) Des during…”
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