Search Results - "Weber, Irene T"

Beyond darunavir: recent development of next generation HIV-1 protease inhibitors to combat drug resistance by Ghosh, Arun K, Weber, Irene T, Mitsuya, Hiroaki

“…We report our recent development of a conceptually new generation of exceptionally potent non-peptidic HIV-1 protease inhibitors that displayed excellent…”
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Machine learning methods accurately predict host specificity of coronaviruses based on spike sequences alone by Kuzmin, Kiril, Adeniyi, Ayotomiwa Ezekiel, DaSouza, Arthur Kevin, Lim, Deuk, Nguyen, Huyen, Molina, Nuria Ramirez, Xiong, Lanqiao, Weber, Irene T., Harrison, Robert W.

“…Coronaviruses infect many animals, including humans, due to interspecies transmission. Three of the known human coronaviruses: MERS, SARS-CoV-1, and…”
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HIV Protease: Historical Perspective and Current Research by Weber, Irene T, Wang, Yuan-Fang, Harrison, Robert W

“…The retroviral protease of human immunodeficiency virus (HIV) is an excellent target for antiviral inhibitors for treating HIV/AIDS. Despite the efficacy of…”
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Evolution of drug resistance in HIV protease by Shah, Dhara, Freas, Christopher, Weber, Irene T, Harrison, Robert W

“…Drug resistance is a critical problem limiting effective antiviral therapy for HIV/AIDS. Computational techniques for predicting drug resistance profiles from…”
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Enhancing Protein Backbone Binding-A Fruitful Concept for Combating Drug-Resistant HIV by Ghosh, Arun K., Anderson, David D., Weber, Irene T., Mitsuya, Hiroaki

“…The evolution of drug resistance is one of the most fundamental problems in medicine. In HIV/AIDS, the rapid emergence of drug‐resistant HIV‐1 variants is a…”
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Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics by Agniswamy, Johnson, Louis, John M, Roche, Julien, Harrison, Robert W, Weber, Irene T

“…We report structural analysis of HIV protease variant PRS17 which was rationally selected by machine learning to represent wide classes of highly…”
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Structure-Based Design of Highly Potent HIV‑1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X‑ray Structural Studies by Ghosh, Arun K, Kovela, Satish, Osswald, Heather L, Amano, Masayuki, Aoki, Manabu, Agniswamy, Johnson, Wang, Yuan-Fang, Weber, Irene T, Mitsuya, Hiroaki

“…We describe here design, synthesis, and biological evaluation of a series of highly potent HIV-1 protease inhibitors containing stereochemically defined and…”
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Discovery of a new flavin N5-adduct in a tyrosine to phenylalanine variant of d-Arginine dehydrogenase by Iyer, Archana, Reis, Renata A.G., Agniswamy, Johnson, Weber, Irene T., Gadda, Giovanni

“…d-Arginine dehydrogenase from Pseudomonas aeruginosa (PaDADH) catalyzes the flavin-dependent oxidation of d-arginine and other d-amino acids. Here, we report…”
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Design of HIV Protease Inhibitors Targeting Protein Backbone: An Effective Strategy for Combating Drug Resistance by Ghosh, Arun K, Chapsal, Bruno D, Weber, Irene T, Mitsuya, Hiroaki

“…The discovery of human immunodeficiency virus (HIV) protease inhibitors (PIs) and their utilization in highly active antiretroviral therapy (HAART) have been a…”
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Potent antiviral HIV-1 protease inhibitor combats highly drug resistant mutant PR20 by Kneller, Daniel W., Agniswamy, Johnson, Ghosh, Arun K., Weber, Irene T.

“…Drug-resistance threatens effective treatment of HIV/AIDS. Clinical inhibitors, including darunavir (1), are ineffective for highly resistant protease mutant…”
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Evaluation of darunavir-derived HIV-1 protease inhibitors incorporating P2′ amide-derivatives: Synthesis, biological evaluation and structural studies by Ghosh, Arun K., Shahabi, Dana, Kipfmiller, Maya, Ghosh, Ajay K., Johnson, Megan, Wang, Yuan-Fang, Agniswamy, Johnson, Amano, Masayuki, Weber, Irene T., Mitsuya, Hiroaki

“…[Display omitted] We report here the synthesis and biological evaluation of darunavir derived HIV-1 protease inhibitors and their functional effect on enzyme…”
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Analysis of drug resistance in HIV protease by Pawar, Shrikant D, Freas, Christopher, Weber, Irene T, Harrison, Robert W

“…Drug resistance in HIV is the major problem limiting effective antiviral therapy. Computational techniques for predicting drug resistance profiles from genomic…”
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Design and Synthesis of Potent HIV‑1 Protease Inhibitors Containing Bicyclic Oxazolidinone Scaffold as the P2 Ligands: Structure–Activity Studies and Biological and X‑ray Structural Studies by Ghosh, Arun K, Williams, Jacqueline N, Ho, Rachel Y, Simpson, Hannah M, Hattori, Shin-ichiro, Hayashi, Hironori, Agniswamy, Johnson, Wang, Yuan-Fang, Weber, Irene T, Mitsuya, Hiroaki

“…We have designed, synthesized, and evaluated a new class of potent HIV-1 protease inhibitors with novel bicyclic oxazolidinone derivatives as the P2 ligand. We…”
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Automated prediction of HIV drug resistance from genotype data by Shen, ChenHsiang, Yu, Xiaxia, Harrison, Robert W, Weber, Irene T

“…HIV/AIDS is a serious threat to public health. The emergence of drug resistance mutations diminishes the effectiveness of drug therapy for HIV/AIDS. Developing…”
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HIV-1 Protease: Structural Perspectives on Drug Resistance by Weber, Irene T, Agniswamy, Johnson

“…Antiviral inhibitors of HIV-1 protease are a notable success of structure-based drug design and have dramatically improved AIDS therapy. Analysis of the…”
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Room Temperature Neutron Crystallography of Drug Resistant HIV‑1 Protease Uncovers Limitations of X‑ray Structural Analysis at 100 K by Gerlits, Oksana, Keen, David A, Blakeley, Matthew P, Louis, John M, Weber, Irene T, Kovalevsky, Andrey

“…HIV-1 protease inhibitors are crucial for treatment of HIV-1/AIDS, but their effectiveness is thwarted by rapid emergence of drug resistance. To better…”
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Long-Range Electrostatics-Induced Two-Proton Transfer Captured by Neutron Crystallography in an Enzyme Catalytic Site by Gerlits, Oksana, Wymore, Troy, Das, Amit, Shen, Chen-Hsiang, Parks, Jerry M., Smith, Jeremy C., Weiss, Kevin L., Keen, David A., Blakeley, Matthew P., Louis, John M., Langan, Paul, Weber, Irene T., Kovalevsky, Andrey

“…Neutron crystallography was used to directly locate two protons before and after a pH‐induced two‐proton transfer between catalytic aspartic acid residues and…”
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Inhibition of autoprocessing of natural variants and multidrug resistant mutant precursors of HIV-1 protease by clinical inhibitors by Louis, John M, Aniana, Annie, Weber, Irene T, Sayer, Jane M

“…Self-cleavage at the N terminus of HIV-1 protease from the Gag-Pol precursor (autoprocessing) is crucial for stabilizing the protease dimer required for onset…”
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Potent HIV‐1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein‐Ligand X‐ray Structural Studies by Ghosh, Arun K., Xia, Zilei, Kovela, Satish, Robinson, William L., Johnson, Megan E., Kneller, Daniel W., Wang, Yuan‐Fang, Aoki, Manabu, Takamatsu, Yuki, Weber, Irene T., Mitsuya, Hiroaki

“…We report the synthesis and biological evaluation of phenylcarboxylic acid and phenylboronic acid containing HIV‐1 protease inhibitors and their functional…”
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Design, Synthesis and X‐Ray Structural Studies of Potent HIV‐1 Protease Inhibitors Containing C‐4 Substituted Tricyclic Hexahydro‐Furofuran Derivatives as P2 Ligands by Ghosh, Arun K., Kovela, Satish, Sharma, Ashish, Shahabi, Dana, Ghosh, Ajay K., Hopkins, Denver R., Yadav, Monika, Johnson, Megan E., Agniswamy, Johnson, Wang, Yuan‐Fang, Hattori, Shin‐Ichiro, Higashi‐Kuwata, Nobuyo, Aoki, Manabu, Amano, Masayuki, Weber, Irene T., Mitsuya, Hiroaki

“…The design, synthesis, X‐ray structural, and biological evaluation of a series of highly potent HIV‐1 protease inhibitors are reported herein. These inhibitors…”
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