Search Results - "Weber, Christopher R."

Automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids by Schuster, Brooke, Junkin, Michael, Kashaf, Sara Saheb, Romero-Calvo, Isabel, Kirby, Kori, Matthews, Jonathan, Weber, Christopher R., Rzhetsky, Andrey, White, Kevin P., Tay, Savaş

“…Three-dimensional (3D) cell culture technologies, such as organoids, are physiologically relevant models for basic and clinical applications. Automated…”
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Dynamic properties of the tight junction barrier by Weber, Christopher R.

“…A principal role of tight junctions is to seal the apical intercellular space and limit paracellular flux of ions and molecules. Despite the fact that tight…”
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OrganoID: A versatile deep learning platform for tracking and analysis of single-organoid dynamics by Matthews, Jonathan M, Schuster, Brooke, Kashaf, Sara Saheb, Liu, Ping, Ben-Yishay, Rakefet, Ishay-Ronen, Dana, Izumchenko, Evgeny, Shen, Le, Weber, Christopher R, Bielski, Margaret, Kupfer, Sonia S, Bilgic, Mustafa, Rzhetsky, Andrey, Tay, Savaş

“…Organoids have immense potential as ex vivo disease models for drug discovery and personalized drug screening. Dynamic changes in individual organoid…”
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Tight junction pore and leak pathways: a dynamic duo by Shen, Le, Weber, Christopher R, Raleigh, David R, Yu, Dan, Turner, Jerrold R

“…Tissue barriers that restrict passage of liquids, ions, and larger solutes are essential for the development of multicellular organisms. In simple organisms…”
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tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state by Shen, Le, Weber, Christopher R, Turner, Jerrold R

“…The tight junction defines epithelial organization. Structurally, the tight junction is comprised of transmembrane and membrane-associated proteins that are…”
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Computational Models of Claudin Assembly in Tight Junctions and Strand Properties by McGuinness, Sarah, Sajjadi, Samaneh, Weber, Christopher R, Khalili-Araghi, Fatemeh

“…Claudins are one of the major components of tight junctions (TJs) that polymerize within the cell membrane and form interactions between cells. Some claudins…”
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Bifidobacteria Stabilize Claudins at Tight Junctions and Prevent Intestinal Barrier Dysfunction in Mouse Necrotizing Enterocolitis by Bergmann, Kelly R, Liu, Shirley X.L, Tian, Runlan, Kushnir, Anna, Turner, Jerrold R, Li, Hong-Lin, Chou, Pauline M, Weber, Christopher R, De Plaen, Isabelle G

“…Whether intestinal barrier disruption precedes or is the consequence of intestinal injury in necrotizing enterocolitis (NEC) remains unknown. Using a neonatal…”
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Dynamic modeling of the tight junction pore pathway by Weber, Christopher R., Turner, Jerrold R.

“…Claudins define paracellular permeability to small molecules by forming ion‐selective pores within the tight junction. We recently demonstrated that claudin‐2…”
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Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity by Qi, Wentao, Weber, Christopher R, Wasland, Kaarin, Savkovic, Suzana D

“…Soy consumption is associated with a lower incidence of colon cancer which is believed to be mediated by one of its of components, genistein. Genistein may…”
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Epithelial Myosin Light Chain Kinase Activation Induces Mucosal Interleukin-13 Expression to Alter Tight Junction Ion Selectivity by Weber, Christopher R., Raleigh, David R., Su, Liping, Shen, Le, Sullivan, Erika A., Wang, Yingmin, Turner, Jerrold R.

“…Intestinal barrier function is reduced in inflammatory bowel disease (IBD). Tumor necrosis factor (TNF) and interleukin (IL)-13, which are up-regulated in IBD,…”
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Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo by Marchiando, Amanda M, Shen, Le, Graham, W. Vallen, Weber, Christopher R, Schwarz, Brad T, Austin, Jotham R. II, Raleigh, David R, Guan, Yanfang, Watson, Alastair J.M, Montrose, Marshall H, Turner, Jerrold R

“…Epithelial paracellular barrier function, determined primarily by tight junction permeability, is frequently disrupted in disease. In the intestine, barrier…”
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Cerebral Cavernous Malformation Proteins in Barrier Maintenance and Regulation by Wei, Shu, Li, Ye, Polster, Sean P, Weber, Christopher R, Awad, Issam A, Shen, Le

“…Cerebral cavernous malformation (CCM) is a disease characterized by mulberry shaped clusters of dilated microvessels, primarily in the central nervous system…”
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MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function by Yu, Dan, Marchiando, Amanda M, Weber, Christopher R, Raleigh, David R, Wang, Yingmin, Shen, Le, Turner, Jerrold R

“…The perijunctional actomyosin ring contributes to myosin light chain kinase (MLCK)-dependent tight junction regulation. However, the specific protein…”
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Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux by Buschmann, Mary M, Shen, Le, Rajapakse, Harsha, Raleigh, David R, Wang, Yitang, Wang, Yingmin, Lingaraju, Amulya, Zha, Juanmin, Abbott, Elliot, McAuley, Erin M, Breskin, Lydia A, Wu, Licheng, Anderson, Kenneth, Turner, Jerrold R, Weber, Christopher R

“…In vitro and in vivo studies implicate occludin in the regulation of paracellular macromolecular flux at steady state and in response to tumor necrosis factor…”
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Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function by Raleigh, David R, Boe, Devin M, Yu, Dan, Weber, Christopher R, Marchiando, Amanda M, Bradford, Emily M, Wang, Yingmin, Wu, Licheng, Schneeberger, Eveline E, Shen, Le, Turner, Jerrold R

“…Although the C-terminal cytoplasmic tail of the tight junction protein occludin is heavily phosphorylated, the functional impact of most individual sites is…”
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Claudin-2-dependent paracellular channels are dynamically gated by Weber, Christopher R, Liang, Guo Hua, Wang, Yitang, Das, Sudipto, Shen, Le, Yu, Alan S L, Nelson, Deborah J, Turner, Jerrold R

“…Intercellular tight junctions form selectively permeable barriers that seal the paracellular space. Trans-tight junction flux has been measured across large…”
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Dynamic migration of γδ intraepithelial lymphocytes requires occludin by Edelblum, Karen L, Shen, Le, Weber, Christopher R, Marchiando, Amanda M, Clay, Bryan S, Wang, Yingmin, Prinz, Immo, Malissen, Bernard, Sperling, Anne I, Turner, Jerrold R

“…γδ intraepithelial lymphocytes (IELs) are located beneath or between adjacent intestinal epithelial cells and are thought to contribute to homeostasis and…”
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AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling by Ferrarotto, Renata, Mishra, Vasudha, Herz, Elad, Yaacov, Adar, Solomon, Oz, Rauch, Rami, Mondshine, Adi, Motin, Maria, Leibovich-Rivkin, Tal, Davis, Matti, Kaye, Joel, Weber, Christopher R., Shen, Le, Pearson, Alexander T., Rosenberg, Ari J., Chen, Xiangying, Singh, Alka, Aster, Jon C., Agrawal, Nishant, Izumchenko, Evgeny

“…Adenoid cystic carcinoma (ACC) is an aggressive salivary gland malignancy with limited treatment options for recurrent or metastatic disease. Due to…”
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Computational Modeling of Claudin Structure and Function by Fuladi, Shadi, Jannat, Ridaka-Wal, Shen, Le, Weber, Christopher R, Khalili-Araghi, Fatemeh

“…Tight junctions form a barrier to control passive transport of ions and small molecules across epithelia and endothelia. In addition to forming a barrier, some…”
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A novel triptolide analog downregulates NF-κB and induces mitochondrial apoptosis pathways in human pancreatic cancer by Tian, Qiaomu, Zhang, Peng, Wang, Yihan, Si, Youhui, Yin, Dengping, Weber, Christopher R, Fishel, Melissa L, Pollok, Karen E, Qiu, Bo, Xiao, Fei, Chong, Anita S

“…Pancreatic cancer is the seventh leading cause of cancer-related death worldwide, and despite advancements in disease management, the 5 -year survival rate…”
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