Search Results - "Weber, Barbara L"

MicroRNAs Exhibit High Frequency Genomic Alterations in Human Cancer by Zhang, Lin, Huang, Jia, Yang, Nuo, Greshock, Joel, Megraw, Molly S., Giannakakis, Antonis, Liang, Shun, Naylor, Tara L., Barchetti, Andrea, Ward, Michelle R., Yao, George, Medina, Angelica, O'Brien-Jenkins, Ann, Katsaros, Dionyssios, Hatzigeorgiou, Artemis, Gimotty, Phyllis A., Weber, Barbara L., Coukos, George

“…MicroRNAs (miRNAs) are endogenous noncoding RNAs, which negatively regulate gene expression. To determine genomewide miRNA DNA copy number abnormalities in…”
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MicroRNA Microarray Identifies Let-7i as a Novel Biomarker and Therapeutic Target in Human Epithelial Ovarian Cancer by NUO YANG, KAUR, Sippy, JOHNSTONE, Cameron N, CHEN, Xian-Ming, LIU, Chang-Gong, QIHONG HUANG, KATSAROS, Dionyssios, CALIN, George Adrian, WEBER, Barbara L, BÜTZOW, Ralf, CROCE, Carlo M, COUKOS, George, VOLINIA, Stefano, LIN ZHANG, GRESHOCK, Joel, LASSUS, Heini, HASEGAWA, Kosei, SHUN LIANG, LEMINEN, Arto, SHAN DENG, SMITH, Lori

“…MicroRNAs (miRNA) are approximately 22-nucleotide noncoding RNAs that negatively regulate protein-coding gene expression in a sequence-specific manner via…”
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miR-210 links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancer by Giannakakis, Antonis, Sandaltzopoulos, Raphael, Greshock, Joel, Liang, Shun, Huang, Jia, Hasegawa, Kosei, Li, Chunsheng, O'Brien-Jenkins, Ann, Katsaros, Dionyssios, Weber, Barbara L., Simon, Celeste, Coukos, George, Zhang, Lin

“…Tumor growth results in hypoxia. Understanding the mechanisms of gene expression reprogramming under hypoxia may provide important clues to cancer…”
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Optimizing the Therapeutic Window of Targeted Drugs in Oncology: Potency‐Guided First‐in‐Human Studies by Goldstein, Matthew J., Peters, Malte, Weber, Barbara L., Davis, Charles B.

“…Many targeted therapies are administered at or near the maximum tolerated dose (MTD). With the advent of precision medicine, a larger therapeutic window is…”
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Bilateral Prophylactic Mastectomy Reduces Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers: The PROSE Study Group by REBBECK, Timothy R, FRIEBEL, Tara, DALY, Mary B, OLOPADE, Olufunmilayo I, WEBER, Barbara L, LYNCH, Henry T, NEUHAUSEN, Susan L, VAN'T VEER, Laura, GARBER, Judy E, EVANS, Gareth R, NAROD, Steven A, ISAACS, Claudine, MATLOFF, Ellen

“…Data on the efficacy of bilateral prophylactic mastectomy for breast cancer risk reduction in women with BRCA1 and BRCA2 (BRCA1/2) mutations are limited,…”
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Ten-Year Multi-Institutional Results of Breast-Conserving Surgery and Radiotherapy in BRCA1/2-Associated Stage I/II Breast Cancer by PIERCE, Lori J, LEVIN, Albert M, NAROD, Steven A, OLIVOTTO, Ivo A, EISEN, Andrea, WHELAN, Timothy J, OLOPADE, Olufunmilayo L, ISAACS, Claudine, MERAJVER, Sofia D, WONG, Julia S, GARBER, Judy E, WEBER, Barbara L, REBBECK, Timothy R, BEN-DAVID, Merav A, FRIEDMAN, Eitan, SOLIN, Lawrence J, HARRIS, Eleanor E, GAFFNEY, David K, HAFFTY, Bruce G, DAWSON, Laura A

“…We compared the outcome of breast-conserving surgery and radiotherapy in BRCA1/2 mutation carriers with breast cancer versus that of matched sporadic controls…”
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Effect of Short-Term Hormone Replacement Therapy on Breast Cancer Risk Reduction After Bilateral Prophylactic Oophorectomy in BRCA1 and BRCA2 Mutation Carriers: The PROSE Study Group by REBBECK, Timothy R, FRIEBEL, Tara, EELES, Rosalind, EVANS, D. Gareth, TOMLINSON, Gail, MATLOFF, Ellen, NAROD, Steven A, EISEN, Andrea, DOMCHEK, Susan, ARMSTRONG, Katrma, WEBER, Barbara L, WAGNER, Theresa, LYNCH, Henry T, GARBER, Judy E, DALY, Mary B, ISAACS, Claudine, OLOPADE, Olufunmilayo I, NEUHAUSEN, Susan L, VAN 'T VEER, Laura

“…Bilateral prophylactic oophorectomy (BPO) is widely used for cancer risk reduction in women with BRCA1/2 mutations. Many premenopausal women choose to take…”
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Mortality after bilateral salpingo-oophorectomy in BRCA1 and BRCA2 mutation carriers: a prospective cohort study by Domchek, Susan M, Friebel, Tara M, Neuhausen, Susan L, Wagner, Theresa, Evans, Gareth, Isaacs, Claudine, Garber, Judy E, Daly, Mary B, Eeles, Rosalind, Matloff, Ellen, Tomlinson, Gail E, Van't Veer, Laura, Lynch, Henry T, Olopade, Olufunmilayo I, Weber, Barbara L, Rebbeck, Timothy R

“…Bilateral prophylactic salpingo-oophorectomy (BPSO) is used widely used to reduce the risk of breast and ovarian cancer in women with BRCA1 and BRCA2…”
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Breast cancer genetics: What we know and what we need by Nathanson, Katherine N, Wooster, Richard, Weber, Barbara L

“…Breast cancer results from genetic and environmental factors leading to the accumulation of mutations in essential genes. Genetic predisposition may have a…”
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Integrative Genomic Analysis of Phosphatidylinositol 3′-Kinase Family Identifies PIK3R3 as a Potential Therapeutic Target in Epithelial Ovarian Cancer by Zhang, Lin, Huang, Jia, Yang, Nuo, Greshock, Joel, Liang, Shun, Hasegawa, Kosei, Giannakakis, Antonis, Poulos, Nikolaos, O'Brien-Jenkins, Ann, Katsaros, Dionyssios, Butzow, Ralf, Weber, Barbara L, Coukos, George

“…Purpose: The phosphatidylinositol 3′-kinase (PI3K) family plays a key regulatory role in various cancer-associated signal transduction pathways. Here, we…”
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Characterization of BRCA1 and BRCA2 Mutations in a Large United States Sample by SINING CHEN, IVERSEN, Edwin S, CORIO, Camille, LEONDARIDIS, Leoni, TOMLINSON, Gail, DUTSON, Debra, KERBER, Rich, AMOS, Christopher I, STRONG, Louise C, BERRY, Donald A, EUHUS, David M, PARMIGIANI, Giovanni, FRIEBEL, Tara, FINKELSTEIN, Dianne, WEBER, Barbara L, EISEN, Andrea, PETERSON, Leif E, SCHILDKRAUT, Joellen M, ISAACS, Claudine, PESHKIN, Beth N

“…An accurate evaluation of the penetrance of BRCA1 and BRCA2 mutations is essential to the identification and clinical management of families at high risk of…”
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ASCO/SSO Review of Current Role of Risk-Reducing Surgery in Common Hereditary Cancer Syndromes by GUILLEM, José G, WOOD, William C, GIARDIELLO, Francis, RODRIGUEZ-BIGAS, Miguel A, CHURCH, James, GRUBER, Stephen, OFFIT, Kenneth, MOLEY, Jeffrey F, BERCHUCK, Andrew, KARLAN, Beth Y, MUTCH, David G, GAGEL, Robert F, WEITZEL, Jeffrey, MORROW, Monica, WEBER, Barbara L

“…Although the etiology of solid cancers is multifactorial, with environmental and genetic factors playing a variable role, a significant portion of the burden…”
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A Combined Array-Based Comparative Genomic Hybridization and Functional Library Screening Approach Identifies mir-30d As an Oncomir in Cancer by NING LI, KAUR, Sippy, KATSAROS, Dionyssios, QIHONG HUANG, BÜTZOW, Ralf, WEBER, Barbara L, COUKOS, George, LIN ZHANG, GRESHOCK, Joel, LASSUS, Heini, XIAOMIN ZHONG, YANLING WANG, LEMINEN, Arto, ZHONGJUN SHAO, XIAOWEN HU, SHUN LIANG

“…Oncomirs are microRNAs (miRNA) that acts as oncogenes or tumor suppressor genes. Efficient identification of oncomirs remains a challenge. Here we report a…”
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A Phase I Trial of the Oral, Multikinase Inhibitor Sorafenib in Combination with Carboplatin and Paclitaxel by Flaherty, Keith T, Schiller, Joan, Schuchter, Lynn M, Liu, Glenn, Tuveson, David A, Redlinger, Maryann, Lathia, Chetan, Xia, Chenghua, Petrenciuc, Oana, Hingorani, Sunil R, Jacobetz, Michael A, Van Belle, Patricia A, Elder, David, Brose, Marcia S, Weber, Barbara L, Albertini, Mark R, O'Dwyer, Peter J

“…Purpose: This study evaluated the safety, maximum tolerated dose, pharmacokinetics, and antitumor activity of sorafenib, a multikinase inhibitor, combined with…”
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High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization by Naylor, Tara L, Greshock, Joel, Wang, Yan, Colligon, Theresa, Yu, Q C, Clemmer, Virginia, Zaks, Tal Z, Weber, Barbara L

“…Genomic aberrations in the form of subchromosomal DNA copy number changes are a hallmark of epithelial cancers, including breast cancer. The goal of the…”
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Application of Breast Cancer Risk Prediction Models in Clinical Practice by DOMCHEK, Susan M, EISEN, Andrea, CALZONE, Kathleen, STOPFER, Jill, BLACKWOOD, Anne, WEBER, Barbara L

“…Breast cancer risk assessment provides an estimation of disease risk that can be used to guide management for women at all levels of risk. In addition, the…”
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Phase I and Pharmacokinetic Study of Lapatinib and Docetaxel in Patients With Advanced Cancer by LORUSSO, Patricia M, JONES, Suzanne F, KOCH, Kevin M, ARYA, Nikita, FLEMING, Ronald A, LOFTISS, Jill, PANDITE, Lini, GADGEEL, Shirish, WEBER, Barbara L, BURRIS, Howard A

“…This phase I study assessed the safety, optimally tolerated regimen (OTR), pharmacokinetics, pharmacodynamics, and preliminary clinical activity of lapatinib…”
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A Comparison of DNA Copy Number Profiling Platforms by GRESHOCK, Joel, BIN FENG, NOGUEIRA, Cristina, IVANOVA, Elena, PERNA, Liana, NATHANSON, Katherine, PROTOPOPOV, Alexei, WEBER, Barbara L, CHIN, Lynda

“…The accurate mapping of recurring DNA copy number aberrations (CNAs), a hallmark feature of the cancer genome, has facilitated the discovery of tumor…”
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Stable Interaction between the Products of the BRCA1 and BRCA2 Tumor Suppressor Genes in Mitotic and Meiotic Cells by Chen, Junjie, Silver, Daniel P, Walpita, Deepika, Cantor, Sharon B, Gazdar, Adi F, Tomlinson, Gail, Couch, Fergus J, Weber, Barbara L, Ashley, Terry, Livingston, David M, Scully, Ralph

“…BRCA1 and BRCA2 account for most cases of familial, early onset breast and/or ovarian cancer and encode products that each interact with hRAD51. Results…”
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Effect of Radiotherapy After Breast-Conserving Treatment in Women With Breast Cancer and Germline BRCA1/2 Mutations by PIERCE, Lori J, STRAWDERMAN, Myla, BERG, Christine, ISAACS, Claudine, HEIMANN, Ruth, OLOPADE, Olufunmilayo I, HAFFTY, Bruce, WEBER, Barbara L, NAROD, Steven A, OLIVIOTTO, Ivo, EISEN, Andrea, DAWSON, Laura, GAFFNEY, David, SOLIN, Lawrence J, NIXON, Asa, GARBER, Judy

“…Recent laboratory data suggest a role for BRCA1/2 in the cellular response to DNA damage. There is a paucity of clinical data, however, examining the effect of…”
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