Search Results - "Weber, Alexander R"

Delayed NLRP3 inflammasome inhibition ameliorates subacute stroke progression in mice by Bellut, Maximilian, Bieber, Michael, Kraft, Peter, Weber, Alexander N R, Stoll, Guido, Schuhmann, Michael K

“…Ischemic stroke immediately evokes a strong neuro-inflammatory response within the vascular compartment, which contributes to primary infarct development under…”
Get full text

Serine/threonine acetylation of TGFβ-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling by Paquette, Nicholas, Conlon, Joseph, Sweet, Charles, Rus, Florentina, Wilson, Lindsay, Pereira, Andrea, Rosadini, Charles V, Goutagny, Nadege, Weber, Alexander N. R, Lane, William S, Shaffer, Scott A, Maniatis, Stephanie, Fitzgerald, Katherine A, Stuart, Lynda, Silverman, Neal

“…The Gram-negative bacteria Yersinia pestis , causative agent of plague, is extremely virulent. One mechanism contributing to Y. pestis virulence is the…”
Get full text

The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells by Bhattacharya, Shreya, Maupin, Alec Jacob, Schlosser, Anders Grønnegaard, Füchtbauer, Ernst-Martin, Gloria, Yamel Cardona, Weber, Alexander N R, Holmskov, Uffe, Moeller, Jesper Bonnet, Templeton, Steven P

“…Chitin, a polysaccharide, is ubiquitously found in nature and has been known to be an active immunogen in mammals, and interacts with Toll-like, mannose and…”
Get full text

Toll and IMD Pathways Synergistically Activate an Innate Immune Response in Drosophila melanogaster by Tanji, Takahiro, Hu, Xiaodi, Weber, Alexander N. R., Ip, Y. Tony

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Investigation of single and synergic effects of NLRC5 and PD-L1 variants on the risk of colorectal cancer by Catalano, Calogerina, da Silva Filho, Miguel Inacio, Frank, Christoph, Jiraskova, Katerina, Vymetalkova, Veronika, Levy, Miroslav, Liska, Vaclav, Vycital, Ondrej, Naccarati, Alessio, Vodickova, Ludmila, Hemminki, Kari, Vodicka, Pavel, Weber, Alexander N R, Försti, Asta

“…Constitutive activation of interferon signaling pathways has been reported in colorectal cancer (CRC), leading to a strong CD8+ T cell response through…”
Get full text

Gadd45a is an RNA binding protein and is localized in nuclear speckles by Sytnikova, Yuliya A, Kubarenko, Andriy V, Schäfer, Andrea, Weber, Alexander N R, Niehrs, Christof

“…The Gadd45 proteins play important roles in growth control, maintenance of genomic stability, DNA repair, and apoptosis. Recently, Gadd45 proteins have also…”
Get full text

Modulation of the CD95-induced apoptosis: the role of CD95 N-glycosylation by Shatnyeva, Olga M, Kubarenko, Andriy V, Weber, Claudia E M, Pappa, Alexander, Schwartz-Albiez, Reinhard, Weber, Alexander N R, Krammer, Peter H, Lavrik, Inna N

“…Protein modifications of death receptor pathways play a central role in the regulation of apoptosis. It has been demonstrated that O-glycosylation of…”
Get full text

Coding variants in NOD-like receptors: An association study on risk and survival of colorectal cancer by Huhn, Stefanie, da Silva Filho, Miguel I, Sanmuganantham, Tharmila, Pichulik, Tica, Catalano, Calogerina, Pardini, Barbara, Naccarati, Alessio, Polakova-Vymetálkova, Veronika, Jiraskova, Katerina, Vodickova, Ludmila, Vodicka, Pavel, Löffler, Markus W, Courth, Lioba, Wehkamp, Jan, Din, Farhat V N, Timofeeva, Maria, Farrington, Susan M, Jansen, Lina, Hemminki, Kari, Chang-Claude, Jenny, Brenner, Hermann, Hoffmeister, Michael, Dunlop, Malcolm G, Weber, Alexander N R, Försti, Asta

“…Nod-like receptors (NLRs) are important innate pattern recognition receptors and regulators of inflammation or play a role during development. We…”
Get full text

Neutrophils: Between host defence, immune modulation, and tissue injury by Kruger, Philipp, Saffarzadeh, Mona, Weber, Alexander N R, Rieber, Nikolaus, Radsak, Markus, von Bernuth, Horst, Benarafa, Charaf, Roos, Dirk, Skokowa, Julia, Hartl, Dominik

“…Neutrophils, the most abundant human immune cells, are rapidly recruited to sites of infection, where they fulfill their life-saving antimicrobial functions…”
Get full text

Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis by Herster, Franziska, Bittner, Zsofia, Archer, Nathan K., Dickhöfer, Sabine, Eisel, David, Eigenbrod, Tatjana, Knorpp, Thomas, Schneiderhan-Marra, Nicole, Löffler, Markus W., Kalbacher, Hubert, Vierbuchen, Tim, Heine, Holger, Miller, Lloyd S., Hartl, Dominik, Freund, Lukas, Schäkel, Knut, Heister, Martin, Ghoreschi, Kamran, Weber, Alexander N. R.

“…Psoriasis is an inflammatory skin disease with strong neutrophil (PMN) infiltration and high levels of the antimicrobial peptide, LL37. LL37 in complex with…”
Get full text

RNA and imidazoquinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signaling events by Colak, Elif, Leslie, Alasdair, Zausmer, Kieran, Khatamzas, Elham, Kubarenko, Andriy V, Pichulik, Tica, Klimosch, Sascha N, Mayer, Alice, Siggs, Owen, Hector, Andreas, Fischer, Roman, Klesser, Benedikt, Rautanen, Anna, Frank, Martin, Hill, Adrian V S, Manoury, Bénédicte, Beutler, Bruce, Hartl, Dominik, Simmons, Alison, Weber, Alexander N R

“…TLRs 7 and 8 are pattern recognition receptors controlling antiviral host defense or autoimmune diseases. Apart from foreign and host RNA, synthetic RNA…”
Get full text

Study of human RIG-I polymorphisms identifies two variants with an opposite impact on the antiviral immune response by Pothlichet, Julien, Burtey, Anne, Kubarenko, Andriy V, Caignard, Gregory, Solhonne, Brigitte, Tangy, Frédéric, Ben-Ali, Meriem, Quintana-Murci, Lluis, Heinzmann, Andrea, Chiche, Jean-Daniel, Vidalain, Pierre-Olivier, Weber, Alexander N R, Chignard, Michel, Si-Tahar, Mustapha

“…RIG-I is a pivotal receptor that detects numerous RNA and DNA viruses. Thus, its defectiveness may strongly impair the host antiviral immunity. Remarkably,…”
Get full text

NLRP3 Inflammasome Assembly in Neutrophils Is Supported by PAD4 and Promotes NETosis Under Sterile Conditions by Münzer, Patrick, Negro, Roberto, Fukui, Shoichi, di Meglio, Lucas, Aymonnier, Karen, Chu, Long, Cherpokova, Deya, Gutch, Sarah, Sorvillo, Nicoletta, Shi, Lai, Magupalli, Venkat Giri, Weber, Alexander N. R., Scharf, Rüdiger E., Waterman, Clare M., Wu, Hao, Wagner, Denisa D.

“…Neutrophil extracellular trap formation (NETosis) and the NLR family pyrin domain containing 3 (NLRP3) inflammasome assembly are associated with a similar…”
Get full text

Sensing of Gram-positive bacteria in Drosophila: GNBP1 is needed to process and present peptidoglycan to PGRP-SA by Wang, L, Weber, A.N.R, Atilano, M.L, Filipe, S.R, Gay, N.J, Ligoxygakis, P

“…Genetic evidence indicates that Drosophila defense against Gram‐positive bacteria is mediated by two putative pattern recognition receptors acting upstream of…”
Get full text

Targeting the NLRP3 Inflammasome via BTK by Weber, Alexander N R

“…The NLRP3 inflammasome represents a critical inflammatory machinery driving pathology in many acute (e. g., myocardial infarction or stroke) and chronic…”
Get full text

Flagellin hypervariable region determines symbiotic properties of commensal Escherichia coli strains by Steimle, Alex, Menz, Sarah, Bender, Annika, Ball, Brianna, Weber, Alexander N R, Hagemann, Thomas, Lange, Anna, Maerz, Jan K, Parusel, Raphael, Michaelis, Lena, Schäfer, Andrea, Yao, Hans, Löw, Hanna-Christine, Beier, Sina, Tesfazgi Mebrhatu, Mehari, Gronbach, Kerstin, Wagner, Samuel, Voehringer, David, Schaller, Martin, Fehrenbacher, Birgit, Autenrieth, Ingo B, Oelschlaeger, Tobias A, Frick, Julia-Stefanie

“…Escherichia coli represents a classical intestinal gram-negative commensal. Despite this commensalism, different E. coli strains can mediate disparate…”
Get full text

MyD88 Adaptor-Like D96N Is a Naturally Occurring Loss-of-Function Variant of TIRAP by George, Julie, Kubarenko, Andriy V, Rautanen, Anna, Mills, Tara C, Colak, Elif, Kempf, Tore, Hill, Adrian V. S, Nieters, Alexandra, Weber, Alexander N. R

“…Signals elicited by TLRs following the detection of microbes are integrated and diversified by a group of four cytoplasmic adaptor molecules featuring an…”
Get full text

Oncogenic MYD88 mutations in lymphoma: novel insights and therapeutic possibilities by Weber, Alexander N. R., Cardona Gloria, Yamel, Çınar, Özcan, Reinhardt, H. Christian, Pezzutto, Antonio, Wolz, Olaf-Oliver

“…Oncogenic MYD88 mutations, most notably the Leu 265 Pro (L265P) mutation, were recently identified as potential driver mutations in various B-cell non-Hodgkin…”
Get full text

Activation of lymphoma-associated MyD88 mutations via allostery-induced TIR-domain oligomerization by Avbelj, Monika, Wolz, Olaf-Oliver, Fekonja, Ota, Benčina, Mojca, Repič, Matej, Mavri, Janez, Krüger, Jens, Schärfe, Charlotta, Delmiro Garcia, Magno, Panter, Gabriela, Kohlbacher, Oliver, Weber, AlexanderN. R., Jerala, Roman

“…Myeloid differentiation 88 (MyD88) is the key signaling adapter of Toll-like and interleukin-1 receptors. Recurrent lymphoma-associated mutations, particularly…”
Get full text

Toll-like receptors as molecular switches by Gay, Nicholas J, Gangloff, Monique, Weber, Alexander N. R

“…Members of the Toll family of single-pass transmembrane receptors are key mediators of innate immunity in both vertebrates and invertebrates. They respond to…”
Get full text