Search Results - "Webborn, Peter J. H"

Mass Spectrometry Imaging in Drug Development by Nilsson, Anna, Goodwin, Richard J. A, Shariatgorji, Mohammadreza, Vallianatou, Theodosia, Webborn, Peter J. H, Andrén, Per E

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Mass Spectrometry Imaging of Cassette-Dosed Drugs for Higher Throughput Pharmacokinetic and Biodistribution Analysis by Swales, John G, Tucker, James W, Strittmatter, Nicole, Nilsson, Anna, Cobice, Diego, Clench, Malcolm R, Mackay, C. Logan, Andren, Per E, Takáts, Zoltán, Webborn, Peter J. H, Goodwin, Richard J. A

“…Cassette dosing of compounds for preclinical drug plasma pharmacokinetic analysis has been shown to be a powerful strategy within the pharmaceutical industry…”
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Actives from MMV Open Access Boxes? A suggested way forward by Samby, Kirandeep, Willis, Paul A, Burrows, Jeremy N, Laleu, Benoît, Webborn, Peter J H

“…It is estimated that more than 1 billion people across the world are affected by a neglected tropical disease (NTD) that requires medical intervention. These…”
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Mapping Drug Distribution in Brain Tissue Using Liquid Extraction Surface Analysis Mass Spectrometry Imaging by Swales, John G., Tucker, James W., Spreadborough, Michael J., Iverson, Suzanne L., Clench, Malcolm R., Webborn, Peter J. H., Goodwin, Richard J. A.

“…Liquid extraction surface analysis mass spectrometry (LESA-MS) is a surface sampling technique that incorporates liquid extraction from the surface of tissue…”
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Use of Hepatocytes to Assess the Contribution of Hepatic Uptake to Clearance in Vivo by SOARS, Matthew G, GRIME, Ken, SPROSTON, Joanne L, WEBBORN, Peter J. H, RILEY, Robert J

“…The wealth of information that has emerged in recent years detailing the substrate specificity of hepatic transporters necessitates an investigation into their…”
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Prediction of the Pharmacokinetics of Atorvastatin, Cerivastatin, and Indomethacin Using Kinetic Models Applied to Isolated Rat Hepatocytes by PAINE, Stuart W, PARKER, Alison J, GARDINER, Philip, WEBBORN, Peter J. H, RILEY, Robert J

“…The disposition of atorvastatin, cerivastatin, and indomethacin, established substrates of rat hepatic basolateral uptake transporters, has been evaluated in…”
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Impact of Hepatic Uptake Transporters on Pharmacokinetics and Drug−Drug Interactions: Use of Assays and Models for Decision Making in the Pharmaceutical Industry by Soars, Mathew G, Webborn, Peter J. H, Riley, Robert J

“…The ability to predict hepatic metabolic clearance is a key component in the design and selection of small molecule drug candidates within the pharmaceutical…”
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Hepatic Uptake in the Dog: Comparison of Uptake in Hepatocytes and Human Embryonic Kidney Cells Expressing Dog Organic Anion-Transporting Polypeptide 1B4 by WILBY, Alison J, MAEDA, Kazuya, COURTNEY, Paul F, DEBORI, Yasuyuki, WEBBORN, Peter J. H, KITAMURA, Yoshiaki, KUSUHARA, Hiroyuki, RILEY, Rob J, SUGIYAMA, Yuichi

“…Although the dog is frequently used in pharmacological, pharmacokinetic, and drug safety studies, little is known about canine drug transporters. Dog organic…”
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AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis by Hong, W. David, Benayoud, Farid, Nixon, Gemma L., Ford, Louise, Johnston, Kelly L., Clare, Rachel H., Cassidy, Andrew, Cook, Darren A. N., Siu, Amy, Shiotani, Motohiro, Webborn, Peter J. H., Kavanagh, Stefan, Aljayyoussi, Ghaith, Murphy, Emma, Steven, Andrew, Archer, John, Struever, Dominique, Frohberger, Stefan J., Ehrens, Alexandra, Hübner, Marc P., Hoerauf, Achim, Roberts, Adam P., Hubbard, Alasdair T. M., Tate, Edward W., Serwa, Remigiusz A., Leung, Suet C., Qie, Li, Berry, Neil G., Gusovsky, Fabian, Hemingway, Janet, Turner, Joseph D., Taylor, Mark J., Ward, Stephen A., O’Neill, Paul M.

“…Onchocerciasis and lymphatic filariasis are two neglected tropical diseases that together affect ∼157 million people and inflict severe disability. Both…”
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Functional Consequences of Active Hepatic Uptake on Cytochrome P450 Inhibition in Rat and Human Hepatocytes by GRIME, Ken, WEBBORN, Peter J. H, RILEY, Robert J

“…A series of cytochrome P450 (P450) inhibition experiments were conducted with four hepatic uptake substrates (AZ3, AZ25, atorvastatin, and pitavastatin) using…”
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Spatial Quantitation of Drugs in tissues using Liquid Extraction Surface Analysis Mass Spectrometry Imaging by Swales, John G., Strittmatter, Nicole, Tucker, James W., Clench, Malcolm R., Webborn, Peter J. H., Goodwin, Richard J. A.

“…Liquid extraction surface analysis mass spectrometry imaging (LESA-MSI) has been shown to be an effective tissue profiling and imaging technique, producing…”
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Design of Helicobacter pylori glutamate racemase inhibitors as selective antibacterial agents: A novel pro-drug approach to increase exposure by Basarab, Gregory S., Hill, Pamela J., Rastagar, Abdullah, Webborn, Peter J.H.

“…To achieve high bioavailability towards the design of Helicobacter pylori antibacterial drugs, a pro-drug approach was implemented wherein a sulfoxide moiety…”
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Development of Pyrazolopyrimidine Anti-Wolbachia Agents for the Treatment of Filariasis by McGillan, Paul, Berry, Neil G, Nixon, Gemma L, Leung, Suet C, Webborn, Peter J. H, Wenlock, Mark C, Kavanagh, Stefan, Cassidy, Andrew, Clare, Rachel H, Cook, Darren A, Johnston, Kelly L, Ford, Louise, Ward, Stephen A, Taylor, Mark J, Hong, W. David, O’Neill, Paul M

“…Anti-Wolbachia therapy has been identified as a viable treatment for combating filarial diseases. Phenotypic screening revealed a series of pyrazolopyrimidine…”
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The right compound in the right assay at the right time: an integrated discovery DMPK strategy by Ballard, Peter, Brassil, Patrick, Bui, Khanh H., Dolgos, Hugues, Petersson, Carl, Tunek, Anders, Webborn, Peter J. H.

“…The high rate of attrition during drug development and its associated high research and development (R&D) cost have put pressure on pharmaceutical companies to…”
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Future directions of imaging MS in pharmaceutical R&D by Goodwin, Richard J A, Webborn, Peter J H

“…MS imaging has rapidly evolved over the last decade, finding roles in all aspects of pharmaceutical research and development. This article discusses possible…”
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From ATP to AZD6140 : The discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis by SPRINGTHORPE, Brian, BAILEY, Andrew, HUNT, Simon F, INCE, Francis, INGALL, Anthony H, KIRK, Ian P, LEESON, Paul D, LEFF, Paul, LEWIS, Richard J, MARTIN, Barrie P, MCGINNITY, Dermot F, MORTIMORE, Michael P, BARTON, Patrick, PAINE, Stuart W, PAIRAUDEAU, Garry, PATEL, Anil, RIGBY, Aaron J, RILEY, Robert J, TEOBALD, Barry J, TOMLINSON, Wendy, WEBBORN, Peter J. H, WILLIS, Paul A, BIRKINSHAW, Timothy N, BONNERT, Roger V, BROWN, Roger C, CHAPMAN, David, DIXON, John, GUILE, Simon D, HUMPHRIES, Robert G

“…Starting from adenosine triphosphate (ATP), the identification of a novel series of P2Y(12) receptor antagonists and exploitation of their SAR is described…”
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The role of pharmacokinetic studies in drug discovery: where are we now, how did we get here and where are we going? by Webborn, Peter Jh

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Robust Assessment of Statistical Significance in the Use of Unbound/Intrinsic Pharmacokinetic Parameters in Quantitative Structure–Pharmacokinetic Relationships with Lipophilicity by Andrew M. Davis, Peter J. H. Webborn, David W. Salt

“…The optimization of pharmacokinetic properties remains one of the most challenging aspects of drug design. Key parameters, clearance and volume of…”
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Drug-phospholipid interactions. 2. Predicting the sites of drug distribution using n-octanol/water and membrane/water distribution coefficients by Barton, P, Davis, A M, McCarthy, D J, Webborn, P J

“…The in vivo tissue distribution of seventeen drugs has been modeled by using estimated n-octanol/water and membrane/water distribution coefficients. In this…”
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