Search Results - "Webber, Philip"

Does CRISPR-Cas open new possibilities for patents or present a moral maze? by Webber, Philip

“…CRISPR-Cas systems, which enable the production of new artificial genes, synthetic proteins and new transgenic organisms, will challenge patent practices…”
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LRRK2 inhibition attenuates microglial inflammatory responses by Moehle, Mark S, Webber, Philip J, Tse, Tonia, Sukar, Nour, Standaert, David G, DeSilva, Tara M, Cowell, Rita M, West, Andrew B

“…Missense mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset Parkinson's disease (PD), and common genetic variation in LRRK2 modifies…”
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GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1 by Stafa, Klodjan, Trancikova, Alzbeta, Webber, Philip J, Glauser, Liliane, West, Andrew B, Moore, Darren J

“…Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of autosomal dominant familial Parkinson's disease (PD) and also…”
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Dependence of Leucine-rich Repeat Kinase 2 (LRRK2) Kinase Activity on Dimerization by Sen, Saurabh, Webber, Philip J., West, Andrew B.

“…Dominant missense mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common known genetic cause of Parkinson disease. LRRK2 encodes a…”
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Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds by Horton, John R, Liu, Xu, Gale, Molly, Wu, Lizhen, Shanks, John R, Zhang, Xing, Webber, Philip J, Bell, Joshua S K, Kales, Stephen C, Mott, Bryan T, Rai, Ganesha, Jansen, Daniel J, Henderson, Mark J, Urban, Daniel J, Hall, Matthew D, Simeonov, Anton, Maloney, David J, Johns, Margaret A, Fu, Haian, Jadhav, Ajit, Vertino, Paula M, Yan, Qin, Cheng, Xiaodong

“…The KDM5/JARID1 family of Fe(II)- and α-ketoglutarate-dependent demethylases removes methyl groups from methylated lysine 4 of histone H3. Accumulating…”
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The OncoPPi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies by Li, Zenggang, Ivanov, Andrei A., Su, Rina, Gonzalez-Pecchi, Valentina, Qi, Qi, Liu, Songlin, Webber, Philip, McMillan, Elizabeth, Rusnak, Lauren, Pham, Cau, Chen, Xiaoqian, Mo, Xiulei, Revennaugh, Brian, Zhou, Wei, Marcus, Adam, Harati, Sahar, Chen, Xiang, Johns, Margaret A., White, Michael A., Moreno, Carlos S., Cooper, Lee A. D., Du, Yuhong, Khuri, Fadlo R., Fu, Haian

“…As genomics advances reveal the cancer gene landscape, a daunting task is to understand how these genes contribute to dysregulated oncogenic pathways…”
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Autophosphorylation in the Leucine-Rich Repeat Kinase 2 (LRRK2) GTPase Domain Modifies Kinase and GTP-Binding Activities by Webber, Philip J., Smith, Archer D., Sen, Saurabh, Renfrow, Matthew B., Mobley, James A., West, Andrew B.

“…The leucine-rich repeat kinase 2 (LRRK2) protein has both guanosine triphosphatase (GTPase) and kinase activities, and mutation in either enzymatic domain can…”
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Corrigendum to “Autophosphorylation in the Leucine-Rich Repeat Kinase 2 (LRRK2) GTPase Domain Modified Kinase and GTP-binding Activities” [J. Mol. Biol. 412(1) (2011) 94–110] by Webber, Philip J., Smith, Archer D., Sen, Saurabh, Renfrow, Matthew B., Mobley, James A., West, Andrew B.

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Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations by Trancikova, Alzbeta, Mamais, Adamantios, Webber, Philip J, Stafa, Klodjan, Tsika, Elpida, Glauser, Liliane, West, Andrew B, Bandopadhyay, Rina, Moore, Darren J

“…Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of autosomal dominant familial Parkinson's disease (PD). LRRK2 encodes a…”
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LRRK2 secretion in exosomes is regulated by 14-3-3 by Fraser, Kyle B, Moehle, Mark S, Daher, João P L, Webber, Philip J, Williams, Jeri Y, Stewart, Carrie A, Yacoubian, Talene A, Cowell, Rita M, Dokland, Terje, Ye, Tong, Chen, Dongquan, Siegal, Gene P, Galemmo, Robert A, Tsika, Elpida, Moore, Darren J, Standaert, David G, Kojima, Kyoko, Mobley, James A, West, Andrew B

“…Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset Parkinson's disease (PD). Emerging evidence suggests a role for LRRK2 in the…”
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Novel pathogenic LRRK2 p.Asn1437His substitution in familial Parkinson's disease by Aasly, Jan O., Vilariño-Güell, Carles, Dachsel, Justus C., Webber, Philip J., West, Andrew B., Haugarvoll, Kristoffer, Johansen, Krisztina K., Toft, Mathias, Nutt, John G., Payami, Haydeh, Kachergus, Jennifer M., Lincoln, Sarah J., Felic, Amela, Wider, Christian, Soto-Ortolaza, Alexandra I., Cobb, Stephanie A., White, Linda R., Ross, Owen A., Farrer, Matthew J.

“…Genealogical investigation of a large Norwegian family (F04) with autosomal dominant parkinsonism has identified 18 affected family members over four…”
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LRRK2 in Parkinson's disease: function in cells and neurodegeneration by Webber, Philip J, West, Andrew B

“…The detailed characterization of the function of leucine-rich repeat kinase 2 (LRRK2) may provide insight into the molecular basis of neurodegeneration in…”
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Investigating bacterial sources of toxicity as an environmental contributor to dopaminergic neurodegeneration by Caldwell, Kim A, Tucci, Michelle L, Armagost, Jafa, Hodges, Tyler W, Chen, Jue, Memon, Shermeen B, Blalock, Jeana E, DeLeon, Susan M, Findlay, Robert H, Ruan, Qingmin, Webber, Philip J, Standaert, David G, Olson, Julie B, Caldwell, Guy A

“…Parkinson disease (PD) involves progressive neurodegeneration, including loss of dopamine (DA) neurons from the substantia nigra. Select genes associated with…”
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Bis(calix[4]diquinone) Receptors:  Cesium- and Rubidium-Selective Redox-Active Ionophores by Webber, Philip R. A, Beer, Paul D, Chen, George Z, Felix, Vitor, Drew, Michael G. B

“…A new class of redox-active ionophore comprised of two calix[4]diquinone moieties connected through either alkylene or pyridylene linkages has been developed…”
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Correction: Corrigendum: The OncoPPi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies by Li, Zenggang, Ivanov, Andrei A., Su, Rina, Gonzalez-Pecchi, Valentina, Qi, Qi, Liu, Songlin, Webber, Philip, McMillan, Elizabeth, Rusnak, Lauren, Pham, Cau, Chen, Xiaoqian, Mo, Xiulei, Revennaugh, Brian, Zhou, Wei, Marcus, Adam, Harati, Sahar, Chen, Xiang, Johns, Margaret A., White, Michael A., Moreno, Carlos S., Cooper, Lee A. D., Du, Yuhong, Khuri, Fadlo R., Fu, Haian

“…Nature Communications 8: Article number: 14356 (2017); Published: 16 February 2017; Updated: 18 April 2017 The original version of this Article contained an…”
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Acute porphyrias may be overlooked in patients taking methenamine hippurate by Webber, Philip R A, Aarsand, Aasne K, Sandvik, Arne K, Skadberg, Øyvind, Lindberg, Morten, Sandberg, Sverre

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Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells by Webber, Philip J, Park, Chanhee, Qui, Min, Ramalingam, Suresh S, Khuri, Fadlo R, Fu, Haian, Du, Yuhong

“…Discovery of effective drug combinations is a promising strategy to improve patient survival. This study explores the impact of heat shock protein 90 (Hsp90)…”
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Patenting of microorganisms by Webber, Philip M

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Potassium Selective Calix[4]semitubes by Webber, Philip R. A., Cowley, Andrew, Drew, Michael G. B., Beer, Paul D.

“…A new class of ionophore consisting of two calix[4]arene units linked through the lower rim by two ethylene chains, in combination with propyl ether and…”
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Priority patent applications by Webber, Philip M

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