Search Results - "Webber, Mark"

Novel approaches to the treatment of bacterial biofilm infections by Hughes, Gareth, Webber, Mark A

“…Bacterial infection remains a major challenge to healthcare and is responsible for significant morbidity and mortality. This situation is becoming complicated…”
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Molecular mechanisms of antibiotic resistance revisited by Darby, Elizabeth M., Trampari, Eleftheria, Siasat, Pauline, Gaya, Maria Solsona, Alav, Ilyas, Webber, Mark A., Blair, Jessica M. A.

“…Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics currently in clinical use and only a few novel drugs in the…”
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Molecular mechanisms of antibiotic resistance by Blair, Jessica M. A., Webber, Mark A., Baylay, Alison J., Ogbolu, David O., Piddock, Laura J. V.

“…Key Points Antibiotic resistance is a global health emergency. Resistance mechanisms exist for all current antibiotics, and few new drugs are in development…”
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Fluoroquinolone resistance: mechanisms, impact on bacteria, and role in evolutionary success by Redgrave, Liam S, Sutton, Sam B, Webber, Mark A, Piddock, Laura J.V

“…Highlights • Fluoroquinolones are broad-spectrum, powerful antibiotics. • Resistance to fluoroquinolones is multifactorial. • Fluoroquinolone resistance…”
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The Antibacterial Activity of Acetic Acid against Biofilm-Producing Pathogens of Relevance to Burns Patients by Halstead, Fenella D, Rauf, Maryam, Moiemen, Naiem S, Bamford, Amy, Wearn, Christopher M, Fraise, Adam P, Lund, Peter A, Oppenheim, Beryl A, Webber, Mark A

“…Localised infections, and burn wound sepsis are key concerns in the treatment of burns patients, and prevention of colonisation largely relies on biocides…”
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Activity of antibacterial phytochemicals and their potential use as natural food preservatives by Sweet, Ryan, Kroon, Paul A., Webber, Mark A.

“…The risk to human health from bacterial foodborne infection is presently controlled by the addition of antimicrobial preservatives to food. However, the use of…”
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An update on the current understanding of the infant skin microbiome and research challenges by Serghiou, Iliana R, Webber, Mark A, Hall, Lindsay J

“…Multiple factors contribute to establishment of skin microbial communities in early life, with perturbations in these ecosystems impacting health. This review…”
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Antibacterial Activity of Blue Light against Nosocomial Wound Pathogens Growing Planktonically and as Mature Biofilms by Halstead, Fenella D, Thwaite, Joanne E, Burt, Rebecca, Laws, Thomas R, Raguse, Marina, Moeller, Ralf, Webber, Mark A, Oppenheim, Beryl A

“…The blue wavelengths within the visible light spectrum are intrinisically antimicrobial and can photodynamically inactivate the cells of a wide spectrum of…”
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MarA, RamA, and SoxS as Mediators of the Stress Response: Survival at a Cost by Holden, Emma R, Webber, Mark A

“…To survive and adapt to changing environments, bacteria have evolved mechanisms to express appropriate genes at appropriate times. Exposure to antimicrobials…”
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Potentiation of curing by a broad-host-range self-transmissible vector for displacing resistance plasmids to tackle AMR by Lazdins, Alessandro, Maurya, Anand Prakash, Miller, Claire E, Kamruzzaman, Muhammad, Liu, Shuting, Stephens, Elton R, Lloyd, Georgina S, Haratianfar, Mona, Chamberlain, Melissa, Haines, Anthony S, Kreft, Jan-Ulrich, Webber, Mark A, Iredell, Jonathan, Thomas, Christopher M

“…Plasmids are potent vehicles for spread of antibiotic resistance genes in bacterial populations and often persist in the absence of selection due to efficient…”
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Common food preservatives impose distinct selective pressures on Salmonella Typhimurium planktonic and biofilm populations by Abi Assaf, Justin, Holden, Emma R., Trampari, Eleftheria, Webber, Mark A.

“…Food preservatives are crucial in controlling microbial growth in processed foods to maintain food safety. Bacterial biofilms pose a threat in the food chain…”
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Identification of binding residues between periplasmic adapter protein (PAP) and RND efflux pumps explains PAP-pump promiscuity and roles in antimicrobial resistance by McNeil, Helen E, Alav, Ilyas, Torres, Ricardo Corona, Rossiter, Amanda E, Laycock, Eve, Legood, Simon, Kaur, Inderpreet, Davies, Matthew, Wand, Matthew, Webber, Mark A, Bavro, Vassiliy N, Blair, Jessica M A

“…Active efflux due to tripartite RND efflux pumps is an important mechanism of clinically relevant antibiotic resistance in Gram-negative bacteria. These pumps…”
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Parallel evolutionary pathways to antibiotic resistance selected by biocide exposure by Webber, Mark A, Whitehead, Rebekah N, Mount, Manuella, Loman, Nick J, Pallen, Mark J, Piddock, Laura J V

“…Biocides are widely used to prevent infection. We aimed to determine whether exposure of Salmonella to various biocides could act as a driver of antibiotic…”
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Meta-analysis confirms BCL2 is an independent prognostic marker in breast cancer by Callagy, Grace M, Webber, Mark J, Pharoah, Paul D P, Caldas, Carlos

“…A number of protein markers have been investigated as prognostic adjuncts in breast cancer but their translation into clinical practice has been impeded by a…”
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AlbaTraDIS: Comparative analysis of large datasets from parallel transposon mutagenesis experiments by Page, Andrew J, Bastkowski, Sarah, Yasir, Muhammad, Turner, A. Keith, Le Viet, Thanh, Savva, George M, Webber, Mark A, Charles, Ian G

“…Bacteria need to survive in a wide range of environments. Currently, there is an incomplete understanding of the genetic basis for mechanisms underpinning…”
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Contribution of Different Mechanisms to Ciprofloxacin Resistance in Salmonella spp by Chang, Man-Xia, Zhang, Jin-Fei, Sun, Yin-Huan, Li, Rong-Sheng, Lin, Xiao-Ling, Yang, Ling, Webber, Mark A., Jiang, Hong-Xia

“…Development of fluoroquinolone resistance can involve several mechanisms that include chromosomal mutations in genes ( gyrAB and parCE ) encoding the target…”
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Bathing babies: current practices in UK neonatal intensive care units by Dhamodaran, Madhuvanthi, Firth, Catriona, Webber, Mark A, Clarke, Paul

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Experiences in fosfomycin susceptibility testing and resistance mechanism determination in Escherichia coli from urinary tract infections in the UK by Cottell, Jennifer L, Webber, Mark A

“…With an increase in the numbers of bacterial isolates resistant to first-line antibiotics, there has been a revival in the use of older drugs including…”
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Rapid draft sequencing and real-time nanopore sequencing in a hospital outbreak of Salmonella by Quick, Joshua, Ashton, Philip, Calus, Szymon, Chatt, Carole, Gossain, Savita, Hawker, Jeremy, Nair, Satheesh, Neal, Keith, Nye, Kathy, Peters, Tansy, De Pinna, Elizabeth, Robinson, Esther, Struthers, Keith, Webber, Mark, Catto, Andrew, Dallman, Timothy J, Hawkey, Peter, Loman, Nicholas J

“…Foodborne outbreaks of Salmonella remain a pressing public health concern. We recently detected a large outbreak of Salmonella enterica serovar Enteritidis…”
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Sticking together: independent evolution of biofilm formation in different species of staphylococci has occurred multiple times via different pathways by Crossman, Lisa, Sims, Leanne, Dean, Rachael, Felgate, Heather, Calvo, Teresa Diaz, Hill, Claire, McNamara, Iain, Webber, Mark A, Wain, John

“…Staphylococci cause a wide range of infections, including implant-associated infections which are difficult to treat due to the presence of biofilms. Whilst…”
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