Search Results - "Webber, Andrea L."

Pan-tumor genomic biomarkers for PD-1 checkpoint blockade-based immunotherapy by Cristescu, Razvan, Mogg, Robin, Ayers, Mark, Albright, Andrew, Murphy, Erin, Yearley, Jennifer, Sher, Xinwei, Liu, Xiao Qiao, Lu, Hongchao, Nebozhyn, Michael, Zhang, Chunsheng, Lunceford, Jared K, Joe, Andrew, Cheng, Jonathan, Webber, Andrea L, Ibrahim, Nageatte, Plimack, Elizabeth R, Ott, Patrick A, Seiwert, Tanguy Y, Ribas, Antoni, McClanahan, Terrill K, Tomassini, Joanne E, Loboda, Andrey, Kaufman, David

“…Programmed cell death protein-1 (PD-1) and programmed cell death ligand-1 (PD-L1) checkpoint blockade immunotherapy elicits durable antitumor effects in…”
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International Union of Basic and Clinical Pharmacology. LXXXVI. Orexin receptor function, nomenclature and pharmacology by Gotter, Anthony L, Webber, Andrea L, Coleman, Paul J, Renger, John J, Winrow, Christopher J

“…Orexin signaling is essential for normal regulation of arousal and behavioral state control and represents an attractive target for therapeutics combating…”
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The Transcriptomic Signature Of Disease Development And Progression Of Nonalcoholic Fatty Liver Disease by Cazanave, Sophie, Podtelezhnikov, Alexei, Jensen, Kristian, Seneshaw, Mulugeta, Kumar, Divya P., Min, Hae-Ki, Santhekadur, Prasanna K., Banini, Bubu, Mauro, Adolfo Gabriele, M. Oseini, Abdul, Vincent, Robert, Tanis, Keith Q., Webber, Andrea L., Wang, Liangsu, Bedossa, Pierre, Mirshahi, Faridoddin, Sanyal, Arun J.

“…A longitudinal molecular model of the development and progression of nonalcoholic fatty liver disease (NAFLD) over time is lacking. We have recently validated…”
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Baseline and post-treatment biomarkers of resistance to anti-PD-1 therapy in acral and mucosal melanoma: an observational study by Shui, Irene M., Liu, Xiao Qiao, Zhao, Qing, Kim, Seung Tae, Sun, Yuan, Yearley, Jennifer H., Choudhury, Tasmiah, Webber, Andrea L., Krepler, Clemens, Cristescu, Razvan, Lee, Jeeyun

“…BackgroundImmunotherapies targeting programmed cell death-1 (PD-1) and its ligands have improved clinical outcomes for advanced melanoma. However, many tumors…”
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Biomarkers predictive of response to pembrolizumab in head and neck cancer by Pfister, David G., Haddad, Robert I., Worden, Francis P., Weiss, Jared, Mehra, Ranee, Chow, Laura Q. M., Liu, Stephen V., Kang, Hyunseok, Saba, Nabil F., Wirth, Lori J., Sukari, Ammar, Massarelli, Erminia, Ayers, Mark, Albright, Andrew, Webber, Andrea L., Mogg, Robin, Lunceford, Jared, Huang, Lingkang, Cristescu, Razvan, Cheng, Jonathan, Seiwert, Tanguy Y., Bauml, Joshua M.

“…Background We performed an integrated biomarker evaluation in pembrolizumab‐treated patients with R/M HNSCC enrolled in KEYNOTE‐012 or KEYNOTE‐055. The…”
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Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): a non-randomised, open-label phase 2 trial by Zhu, Andrew X, Finn, Richard S, Edeline, Julien, Cattan, Stephane, Ogasawara, Sadahisa, Palmer, Daniel, Verslype, Chris, Zagonel, Vittorina, Fartoux, Laetitia, Vogel, Arndt, Sarker, Debashis, Verset, Gontran, Chan, Stephen L, Knox, Jennifer, Daniele, Bruno, Webber, Andrea L, Ebbinghaus, Scot W, Ma, Junshui, Siegel, Abby B, Cheng, Ann-Lii, Kudo, Masatoshi, Alistar, Angela, Asselah, Jamil, Blanc, Jean-Frederic, Borbath, Ivan, Cannon, Timothy, Chung, Ki, Cohn, Allen, Cosgrove, David P, Damjanov, Nevena, Gupta, Mukul, Karino, Yoshivasu, Karwal, Mark, Kaubisch, Andreas, Kelley, Robin, Van Laethem, Jena-Luc, Larson, Timothy, Lee, James, Li, Daneng, Manhas, Atisha, Manji, Gulam Abbas, Numata, Kazushi, Parsons, Benjamin, Paulson, Andrew S., Pinto, Carmine, Ramirez, Robert, Ratnam, Suresh, Rizell, Magnus, Rosmorduc, Olivier, Sada, Yvonne, Sasaki, Yutaka, Stal, Per I, Strasser, Simone, Trojan, Joerg, Vaccaro, Gina, Van Vlierberghe, Hans, Weiss, Alan, Weiss, Karl-Heinz, Yamashita, Tatsuya

“…Immune checkpoint blockade therapy has shown promising results in patients with advanced hepatocellular carcinoma. We aimed to assess the efficacy and safety…”
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Dual role of Nr2e3 in photoreceptor development and maintenance by Webber, Andrea L., Hodor, Paul, Thut, Catherine J., Vogt, Thomas F., Zhang, Theresa, Holder, Daniel J., Petrukhin, Konstantin

“…Nr2e3 is a photoreceptor-specific nuclear receptor believed to play a role in photoreceptor development, differentiation, and survival. Much research has…”
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Results of an open-label phase 1b study of the ERK inhibitor MK-8353 plus the MEK inhibitor selumetinib in patients with advanced or metastatic solid tumors by Stathis, Anastasios, Tolcher, Anthony W., Wang, Judy S., Renouf, Daniel J., Chen, Lin-Chi, Suttner, Leah H., Freshwater, Tomoko, Webber, Andrea L., Nayak, Tapan, Siu, Lillian L.

“…Aim: We evaluated MK-8353 (small molecule inhibitor of extracellular signal-regulated kinase 1/2) plus selumetinib (mitogen-activated extracellular…”
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A phase 1 trial of the MEK inhibitor selumetinib in combination with pembrolizumab for advanced or metastatic solid tumors by Chénard-Poirier, Maxime, Hansen, Aaron R., Gutierrez, Martin E., Rasco, Drew, Xing, Yan, Chen, Lin-Chi, Zhou, Heng, Webber, Andrea L., Freshwater, Tomoko, Sharma, Manish R.

“…Summary MEK inhibitors have immunomodulatory activity and potential for synergistic activity when combined with PD-1 inhibitors. We evaluated selumetinib…”
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Cellular Gene Modulation of HIV-Infected CD4 T Cells in Response to Serial Treatment with the Histone Deacetylase Inhibitor Vorinostat by Maxwell, Jill W, Falcinelli, Shane D, Nefedov, Alexey, Dorfmeier, Corin, Wu, Guoxin, Dewey, Morgan, Webber, Andrea L, Archin, Nancie M, Margolis, David M, Hazuda, Daria J, Barnard, Richard J O, Howell, Bonnie J

“…Histone deacetylase inhibitors (HDACi) are the most widely studied HIV latency-reversing agents (LRAs). The HDACi suberoylanilide hydroxamic acid (vorinostat…”
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Fine‐Needle Aspiration for the Evaluation of Hepatic Pharmacokinetics of Vaniprevir: A Randomized Trial in Patients With Hepatitis C Virus Infection by Gao, Wei, Webber, Andrea L., Maxwell, Jill, Anderson, Melanie, Caro, Luzelena, Chung, Chris, Miltenburg, André M.M., Popa, Serghei, Van Dyck, Kristien, Wenning, Larissa, Mangin, Eric, Fandozzi, Christine, Railkar, Radha, Shire, Norah J., Fraser, Iain, Howell, Bonnie, Talal, Andrew H., Stoch, S. Aubrey

“…Fine‐needle aspiration (FNA) for serial hepatic sampling may be an efficient and less invasive alternative to core needle biopsy (CNB), the current standard…”
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Location of enhancers is essential for the imprinting of H19 and Igf2 genes by Tilghman, Shirley M, Webber, Andrea L, Ingram, Robert S, Levorse, John M

“…Genomic imprinting is the process in mammals by which gamete-specific epigenetic modifications establish the differential expression of the two alleles of a…”
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Author Correction: The Transcriptomic Signature Of Disease Development And Progression Of Nonalcoholic Fatty Liver Disease by Cazanave, Sophie, Podtelezhnikov, Alexei, Jensen, Kristian, Seneshaw, Mulugeta, Kumar, Divya P., Min, Hae-Ki, Santhekadur, Prasanna K., Banini, Bubu, Mauro, Adolfo Gabriele, Oseini, Abdul M., Vincent, Robert, Tanis, Keith Q., Webber, Andrea L., Wang, Liangsu, Bedossa, Pierre, Mirshahi, Faridoddin, Sanyal, Arun J.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Identification of proximal biomarkers of PKC agonism and evaluation of their role in HIV reactivation by Vemula, Sai Vikram, Maxwell, Jill W., Nefedov, Alexey, Wan, Bang-Lin, Steve, Justin, Newhard, William, Sanchez, Rosa I., Tellers, David, Barnard, Richard J., Blair, Wade, Hazuda, Daria, Webber, Andrea L., Howell, Bonnie J.

“…The HIV latent CD4+ T cell reservoir is broadly recognized as a barrier to HIV cure. Induction of HIV expression using protein kinase C (PKC) agonists is one…”
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Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption by Feiner, L, Webber, A L, Brown, C B, Lu, M M, Jia, L, Feinstein, P, Mombaerts, P, Epstein, J A, Raper, J A

“…Semaphorin 3C is a secreted member of the semaphorin gene family. To investigate its function in vivo, we have disrupted the semaphorin 3C locus in mice by…”
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PlexinA2 and semaphorin signaling during cardiac neural crest development by Brown, C B, Feiner, L, Lu, M M, Li, J, Ma, X, Webber, A L, Jia, L, Raper, J A, Epstein, J A

“…Classic studies using avian model systems have demonstrated that cardiac neural crest cells are required for proper development of the cardiovascular system…”
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Haploinsufficiency Is Not the Key Mechanism of Pathogenesis in a Heterozygous Elovl4 Knockout Mouse Model of STGD3 Disease by Raz-Prag, Dorit, Ayyagari, Radha, Fariss, Robert N, Mandal, Md Nawajes A, Vasireddy, Vidyullatha, Majchrzak, Sharon, Webber, Andrea L, Bush, Ronald A, Salem, Norman, Jr, Petrukhin, Konstantin, Sieving, Paul A

“…Autosomal dominant Stargardt-like (STGD3) disease results from mutations in the ELOVL4 gene (elongation of very-long-chain fatty acids). This study was…”
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Identification of potent agonists of photoreceptor-specific nuclear receptor (NR2E3) and preparation of a radioligand by Wolkenberg, Scott E., Zhao, Zhijian, Kapitskaya, Marianna, Webber, Andrea L., Petrukhin, Konstantin, Tang, Yui Sing, Dean, Dennis C., Hartman, George D., Lindsley, Craig W.

“…Agonists of NR2E3 (PNR, RNR) have been identified and optimized to EC 50 < 200 nM. A tritiated analogue of one agonist was prepared to aid in the development…”
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Pharmacological Validation of Candidate Causal Sleep Genes Identified in an N2 Cross by Brunner, Joseph I., Gotter, Anthony L., Millstein, Joshua, Garson, Susan, Binns, Jacquelyn, Fox, Steven V., Savitz, Alan T., Yang, He S., Fitzpatrick, Karrie, Zhou, Lili, Owens, Joseph R., Webber, Andrea L., Vitaterna, Martha H., Kasarskis, Andrew, Uebele, Victor N., Turek, Fred, Renger, John J., Winrow, Christopher J.

“…Despite the substantial impact of sleep disturbances on human health and the many years of study dedicated to understanding sleep pathologies, the underlying…”
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Association between beta-catenin ( CTNNB1 ) mutations and clinical outcomes of pembrolizumab in advanced hepatocellular carcinoma (aHCC): Exploratory analyses from KEYNOTE-240 by Kudo, Masatoshi, Cheng, Ann-Lii, Merle, Philippe, Ryoo, Baek-Yeol, Decaens, Thomas, Cicin, Irfan, Dajani, Olav, Al-Rajabi, Raed Moh'd Taiseer, Peron, Jean-Marie, Chan, Stephen Lam, Knox, Jennifer J., Daniele, Bruno, Suttner, Leah, Webber, Andrea L, Pena, Carol Elaine, Cristescu, Razvan, Chen, Cai, Hatogai, Ken, Siegel, Abby B., Finn, Richard S.

“…4109 Background: CTNNB1 mutations ( CTNNB1mut) occur in approximately 30% of HCC tumors and may result in constitutive activation of CTNNB1, leading to the…”
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