Search Results - "Webb, Murray S."

Influence of poly(ethylene glycol) grafting density and polymer length on liposomes: Relating plasma circulation lifetimes to protein binding by Dos Santos, Nancy, Allen, Christine, Doppen, Anne-Marie, Anantha, Malathi, Cox, Kelly A.K., Gallagher, Ryan C., Karlsson, Goran, Edwards, Katarina, Kenner, Gail, Samuels, Lacey, Webb, Murray S., Bally, Marcel B.

“…The incorporation of poly(ethylene glycol) (PEG)-conjugated lipids in lipid-based carriers substantially prolongs the circulation lifetime of liposomes…”
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Treatment of colorectal cancer using a combination of liposomal irinotecan (Irinophore C™) and 5-fluorouracil by Hare, Jennifer I, Neijzen, Robert W, Anantha, Malathi, Dos Santos, Nancy, Harasym, Natashia, Webb, Murray S, Allen, Theresa M, Bally, Marcel B, Waterhouse, Dawn N

“…To investigate the use of liposomal irinotecan (Irinophore C™) plus or minus 5-fluorouracil (5-FU) for the treatment of colorectal cancer. The effect of…”
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Irinophore C: A Liposome Formulation of Irinotecan with Substantially Improved Therapeutic Efficacy against a Panel of Human Xenograft Tumors by RAMSAY, Euan C, ANANTHA, Malathi, ZASTRE, Jason, MEIJS, Marieke, ZONDERHUIS, Jet, STRUTT, Dita, WEBB, Murray S, WATERHOUSE, Dawn, BALLYL, Marcel B

“…Purpose: To assess the pharmacokinetics, tumor drug accumulation, and therapeutic activity of Irinophore C, a novel liposomal formulation of irinotecan…”
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Intracellular Delivery and Antibacterial Activity of Gentamicin Encapsulated in pH-Sensitive Liposomes by LUTWYCHE, P, CORDEIRO, C, WISEMAN, D. J, ST-LOUIS, M, UH, M, HOPE, M. J, WEBB, M. S, FINLAY, B. B

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Antibacterial Efficacy of Gentamicin Encapsulated in pH-Sensitive Liposomes against an In Vivo Salmonella enterica Serovar Typhimurium Intracellular Infection Model by CORDEIRO, C, WISEMAN, D. J, LUTWYCHE, P, UH, M, EVANS, J. C, FINLAY, B. B, WEBB, M. S

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Antibacterial Efficacy against an In Vivo Salmonella typhimurium Infection Model and Pharmacokinetics of a Liposomal Ciprofloxacin Formulation by WEBB, M. S, BOMAN, N. L, WISEMAN, D. J, SAXON, D, SUTTON, K, WONG, K. F, LOGAN, P, HOPE, M. J

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Irinophore C™, a lipid nanoparticle formulation of irinotecan, abrogates the gastrointestinal effects of irinotecan in a rat model of clinical toxicities by Waterhouse, Dawn N., Sutherland, Brent W., Santos, Nancy Dos, Masin, Dana, Osooly, Maryam, Strutt, Dita, Ostlund, Christina, Anantha, Malathi, Harasym, Natashia, Manisali, Irina, Wehbe, Mohamed, Bally, Marcel B., Webb, Murray S.

“…Summary Irinotecan is a water-soluble camptothecin derivative with clinical activity against colorectal and small cell lung cancers and is currently a standard…”
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Liposomal and nonliposomal drug pharmacokinetics after administration of liposome-encapsulated vincristine and their contribution to drug tissue distribution properties by Krishna, R, Webb, M S, St Onge, G, Mayer, L D

“…We have determined the pharmacokinetics of liposomal vincristine, in a Lewis lung carcinoma solid tumor model in mice, with the aim of differentiating the…”
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In vitro and in vivo characterization of a combination chemotherapy formulation consisting of vinorelbine and phosphatidylserine by Webb, Murray S., Johnstone, Sharon, Morris, Tara J., Kennedy, Allison, Gallagher, Ryan, Harasym, Natashia, Harasym, Troy, Shew, Clifford R., Tardi, Paul, Dragowska, Wieslawa H., Mayer, Lawrence D., Bally, Marcel B.

“…The purpose of these studies was to design an intravenous drug formulation consisting of two active agents having synergistic in vitro activity. Specifically,…”
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Comparison of different hydrophobic anchors conjugated to poly(ethylene glycol): effects on the pharmacokinetics of liposomal vincristine by Webb, Murray S., Saxon, Dawn, Wong, Frances M.P., Lim, Howard J., Wang, Zhao, Bally, Marcel B., Choi, Lewis S.L., Cullis, Pieter R., Mayer, Lawrence D.

“…Poly(ethylene glycol) (PEG) conjugated lipids have been used to increase the circulation longevity of liposomal carriers encapsulating therapeutic compounds…”
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Gene silencing in the development of personalized cancer treatment: the targets, the agents and the delivery systems by Verreault, Maite, Webb, Murray S, Ramsay, Euan C, Bally, Marcel B

“…The advent of sophisticated experimental tools that can probe the molecular pathology of cancer has revealed a number of genes and gene families that could…”
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Interactions between soluble sugars and POPC (1-palmitoyl-2-oleoylphosphatidylcholine) during dehydration: vitrification of sugars alters the phase behavior of the phospholipid by Koster, K L, Webb, M S, Bryant, G, Lynch, D V

“…The phase behavior of 1-palmitoyl-2-oleoylphosphatidylcholine (POPC) was characterized as a function of hydration in the presence of combinations of sugars…”
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A comparison of freezing injury in oat and rye: two cereals at the extremes of freezing tolerance by Webb, M.S, Uemura, M, Steponkus, P.L

“…A detailed analysis of cold acclimation of a winter rye (Secale cereale L. cv Puma), a winter oat (Avena sativa L. cv Kanota), and a spring oat cultivar (Ogle)…”
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Preparation, characterization, and biological analysis of liposomal formulations of vincristine by Waterhouse, Dawn N, Madden, Thomas D, Cullis, Pieter R, Bally, Marcel B, Mayer, Lawrence D, Webb, Murray S

“…Vincristine is a dimeric Catharanthus alkaloid derived from the Madagascan periwinkle that acts by binding to tubulin and blocking metaphase in actively…”
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Effects of temperature on the phase behavior and permeability of thylakoid lipid vesicles. Relevance to chilling stress by Webb, M.S. (Cornell University, Ithaca, NY), Lynch, D.V, Green, B.R

“…Large unilamellar vesicles composed of thylakoid glycolipids, phosphatidylglycerol, and varying proportions of dipalmitoylphosphatidylglycerol (DPPG) have been…”
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A Literature Review of Single Agent Treatment of Multiply Relapsed Aggressive Non-Hodgkin's Lymphoma by Webb, Murray S., Saltman, David L., Connors, Joseph M., Goldie, James H.

“…To analyze the available literature describing the treatment of relapsed aggressive non-Hodgkin's lymphoma (NHL) with single-agent chemotherapies, several…”
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Freeze-induced membrane ultrastructural alterations in rye (Secale cereale) leaves by Webb, M.S, Steponkus, P.L

“…Freezing injury in protoplasts isolated from leaves of nonacclimated rye (Secale cereale cv Puma) is associated with the formation of the inverted hexagonal…”
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Effects of plant sterols on the hydration and phase behavior of DOPE/DOPC mixtures by Webb, Murray S., Irving, Thomas C., Steponkus, Peter L.

“…Freeze-induced injury of protoplasts of non-acclimated rye and oat is associated with the formation of the inverted hexagonal (H II) phase in regions where the…”
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Effects of COR6.6 and COR15am polypeptides encoded by COR (cold-regulated) genes of Arabidopsis thaliana on dehydration-induced phase transitions of phospholipid membranes by Murray S. Webb, Gilmour, Sarah J., Thomashow, Michael F., Steponkus, Peter L.

“…Cold acclimation of Arabidopsis thaliana includes the expression of cold-regulated (COR) genes and the accumulation of COR polypeptides. The hydration…”
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Cerebrosides alter the lyotropic and thermotropic phase transitions of DOPE:DOPC and DOPE:DOPC:sterol mixtures by Webb, Murray S, Irving, Thomas C, Steponkus, Peter L

“…Freezing injury in rye and oat is a consequence of the formation of the inverted hexagonal (H II) phase in regions where the plasma membrane is brought into…”
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