Search Results - "Webb, Jonathan N."

Aggregation of Granulocyte Colony Stimulating Factor under Physiological Conditions:  Characterization and Thermodynamic Inhibition by Krishnan, Sampathkumar, Chi, Eva Y, Webb, Jonathan N, Chang, Byeong S, Shan, Daxian, Goldenberg, Merrill, Manning, Mark C, Randolph, Theodore W, Carpenter, John F

“…We have investigated the aggregation of recombinant human granulocyte colony stimulating factor (rhGCSF), a protein that rapidly aggregates and precipitates at…”
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Quaternary conformational stability: The effect of reversible self-association on the fibrillation of two insulin analogs by Ludwig, D. Brett, Webb, Jonathan N., Fernández, Cristina, Carpenter, John F., Randolph, Theodore W.

“…Under conditions relevant to the manufacturing of insulin (e.g., pH 3, room temperature), biosynthetic human insulin (BHI), and Lispro insulin (Lispro) require…”
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Stability of Subtilisin and Lysozyme under High Hydrostatic Pressure by Webb, Jonathan N., Carpenter, John F., Randolph, Theodore W.

“…The stabilities of subtilisin and lysozyme under hydrostatic pressures up to 200 MPa were investigated for up to 7 days at 25 °C. Methods were chosen to assess…”
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Partial Molar Volume, Surface Area, and Hydration Changes for Equilibrium Unfolding and Formation of Aggregation Transition State: High-Pressure and Cosolute Studies on Recombinant Human IFN-γ by Webb, Jonathan N., Webb, Serena D., Cleland, Jeffrey L., Carpenter, John F., Randolph, Theodore W.

“…The equilibrium dissociation of recombinant human IFN-γ was monitored as a function of pressure and sucrose concentration. The partial molar volume change for…”
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Pressure dependence of subtilisin crystallization kinetics by Waghmare, Ruta Y, Webb, Jonathan N, Randolph, Theodore W, Larson, Maurice A, Glatz, Charles E

“…The effect of pressures from atmospheric to 100 MPa on crystallization of Purafect subtilisin was investigated. The overall crystallization rate was lower at…”
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Partial molar volume, surface area, and hydration changes for equilibrium unfolding and formation of aggregation transition state: High-pressure and cosolute studies by Webb, Jonathan N, Webb, Serena D, Cleland, Jeffrey L, Carpenter, John F, Randolph, Theodore W

“…The equilibrium dissociation of recombinant human IFN-gamma was monitored as a function of pressure and sucrose concentration. The partial molar volume change…”
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Freezing bulk-scale biopharmaceuticals using common techniques -- and the magnitude of freeze-concentration by Serena Donnelly Webb, Sesin, David F, Kincaid, Aimee C, Webb, Jonathan N, Hughes, Timothy G

“…Large-scale freezing and thawing is commonly used in biopharmaceutical manufacturing but is not well understood. Free-thaw variations can exist within or…”
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