Search Results - "Webb, Gabriela"

TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection by Chew, Glen M, Fujita, Tsuyoshi, Webb, Gabriela M, Burwitz, Benjamin J, Wu, Helen L, Reed, Jason S, Hammond, Katherine B, Clayton, Kiera L, Ishii, Naoto, Abdel-Mohsen, Mohamed, Liegler, Teri, Mitchell, Brooks I, Hecht, Frederick M, Ostrowski, Mario, Shikuma, Cecilia M, Hansen, Scott G, Maurer, Mark, Korman, Alan J, Deeks, Steven G, Sacha, Jonah B, Ndhlovu, Lishomwa C

“…HIV infection induces phenotypic and functional changes to CD8+ T cells defined by the coordinated upregulation of a series of negative checkpoint receptors…”
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The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques by Webb, Gabriela M, Molden, Jhomary, Busman-Sahay, Kathleen, Abdulhaqq, Shaheed, Wu, Helen L, Weber, Whitney C, Bateman, Katherine B, Reed, Jason S, Northrup, Mina, Maier, Nicholas, Tanaka, Shiho, Gao, Lina, Davey, Brianna, Carpenter, Benjamin L, Axthelm, Michael K, Stanton, Jeffrey J, Smedley, Jeremy, Greene, Justin M, Safrit, Jeffrey T, Estes, Jacob D, Skinner, Pamela J, Sacha, Jonah B

“…Despite the success of antiretroviral therapy (ART) to halt viral replication and slow disease progression, this treatment is not curative and there remains an…”
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CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14 by Patterson, Bruce K., Seethamraju, Harish, Dhody, Kush, Corley, Michael J., Kazempour, Kazem, Lalezari, Jay, Pang, Alina P.S., Sugai, Christopher, Mahyari, Eisa, Francisco, Edgar B., Pise, Amruta, Rodrigues, Hallison, Wu, Helen L., Webb, Gabriela M., Park, Byung S., Kelly, Scott, Pourhassan, Nader, Lelic, Alina, Kdouh, Lama, Herrera, Monica, Hall, Eric, Bimber, Benjamin N., Plassmeyer, Matthew, Gupta, Raavi, Alpan, Oral, O’Halloran, Jane A., Mudd, Philip A., Akalin, Enver, Ndhlovu, Lishomwa C., Sacha, Jonah B.

“…•Anti-CCR5 humanized monoclonal antibody restored CD8 counts in COVID patients.•Inversely correlated with decreases in plasma viral load (pVL) by day…”
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Comparison of the Superagonist Complex, ALT-803, to IL15 as Cancer Immunotherapeutics in Animal Models by Rhode, Peter R, Egan, Jack O, Xu, Wenxin, Hong, Hao, Webb, Gabriela M, Chen, Xiaoyue, Liu, Bai, Zhu, Xiaoyun, Wen, Jinghai, You, Lijing, Kong, Lin, Edwards, Ana C, Han, Kaiping, Shi, Sixiang, Alter, Sarah, Sacha, Jonah B, Jeng, Emily K, Cai, Weibo, Wong, Hing C

“…IL15, a potent stimulant of CD8(+) T cells and natural killer (NK) cells, is a promising cancer immunotherapeutic. ALT-803 is a complex of an IL15 superagonist…”
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Immune restoration by TIGIT blockade is insufficient to control chronic SIV infection by Webb, Gabriela M, Pessoa, Cleiton T, McCullen, Allyson J, Hwang, Joseph M, Humkey, Matthew C, Thormin-Odum, Raymond, Kukula, Kaitlyn A, Smedley, Jeremy, Fischer, Miranda, Sciurba, Joseph, Bochart, Rachele M, Shriver-Munsch, Christine, Ndhlovu, Lishomwa C, Sacha, Jonah B

“…TIGIT is a negative immune checkpoint receptor associated with T cell exhaustion in cancer and HIV. TIGIT upregulation in virus-specific CD8 T cells and NK…”
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Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission by Chang, Xiao L., Webb, Gabriela M., Wu, Helen L., Greene, Justin M., Abdulhaqq, Shaheed, Bateman, Katherine B., Reed, Jason S., Pessoa, Cleiton, Weber, Whitney C., Maier, Nicholas, Chew, Glen M., Gilbride, Roxanne M., Gao, Lina, Agnor, Rebecca, Giobbi, Travis, Torgerson, Jeffrey, Siess, Don, Burnett, Nicole, Fischer, Miranda, Shiel, Oriene, Moats, Cassandra, Patterson, Bruce, Dhody, Kush, Kelly, Scott, Pourhassan, Nader, Magnani, Diogo M., Smedley, Jeremy, Bimber, Benjamin N., Haigwood, Nancy L., Hansen, Scott G., Brown, Timothy R., Ndhlovu, Lishomwa C., Sacha, Jonah B.

“…In the absence of a prophylactic vaccine, the use of antiretroviral therapy (ART) as pre-exposure prophylaxis (PrEP) to prevent HIV acquisition by uninfected…”
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FcRn-enhancing mutations lead to increased and prolonged levels of the HIV CCR5-blocking monoclonal antibody leronlimab in the fetuses and newborns of pregnant rhesus macaques by Zikos, Joanna, Webb, Gabriela M, Wu, Helen L, Reed, Jason S, Watanabe, Jennifer, Usachenko, Jodie L, Shaqra, Ala M, Schiffer, Celia A, Van Rompay, Koen K A, Sacha, Jonah B, Magnani, Diogo M

“…Prenatal administration of monoclonal antibodies (mAbs) is a strategy that could be exploited to prevent viral infections during pregnancy and early life. To…”
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CCR5 Receptor Occupancy Analysis Reveals Increased Peripheral Blood CCR5+CD4+ T Cells Following Treatment With the Anti-CCR5 Antibody Leronlimab by Chang, Xiao L, Wu, Helen L, Webb, Gabriela M, Tiwary, Meenakshi, Hughes, Colette, Reed, Jason S, Hwang, Joseph, Waytashek, Courtney, Boyle, Carla, Pessoa, Cleiton, Sylwester, Andrew W, Morrow, David, Belica, Karina, Fischer, Miranda, Kelly, Scott, Pourhassan, Nader, Bochart, Rachele M, Smedley, Jeremy, Recknor, Christopher P, Hansen, Scott G, Sacha, Jonah B

“…CCR5 plays a central role in infectious disease, host defense, and cancer progression, thereby making it an ideal target for therapeutic development. Notably,…”
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The Role of MHC-E in T Cell Immunity Is Conserved among Humans, Rhesus Macaques, and Cynomolgus Macaques by Wu, Helen L, Wiseman, Roger W, Hughes, Colette M, Webb, Gabriela M, Abdulhaqq, Shaheed A, Bimber, Benjamin N, Hammond, Katherine B, Reed, Jason S, Gao, Lina, Burwitz, Benjamin J, Greene, Justin M, Ferrer, Fidel, Legasse, Alfred W, Axthelm, Michael K, Park, Byung S, Brackenridge, Simon, Maness, Nicholas J, McMichael, Andrew J, Picker, Louis J, O'Connor, David H, Hansen, Scott G, Sacha, Jonah B

“…MHC-E is a highly conserved nonclassical MHC class Ib molecule that predominantly binds and presents MHC class Ia leader sequence-derived peptides for NK cell…”
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Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques by Burwitz, Benjamin J., Wettengel, Jochen M., Mück-Häusl, Martin A., Ringelhan, Marc, Ko, Chunkyu, Festag, Marvin M., Hammond, Katherine B., Northrup, Mina, Bimber, Benjamin N., Jacob, Thomas, Reed, Jason S., Norris, Reed, Park, Byung, Moller-Tank, Sven, Esser, Knud, Greene, Justin M., Wu, Helen L., Abdulhaqq, Shaheed, Webb, Gabriela, Sutton, William F., Klug, Alex, Swanson, Tonya, Legasse, Alfred W., Vu, Tania Q., Asokan, Aravind, Haigwood, Nancy L., Protzer, Ulrike, Sacha, Jonah B.

“…Hepatitis B virus (HBV) is a major global health concern, and the development of curative therapeutics is urgently needed. Such efforts are impeded by the lack…”
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Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes by Burwitz, Benjamin J., Wu, Helen L., Abdulhaqq, Shaheed, Shriver-Munsch, Christine, Swanson, Tonya, Legasse, Alfred W., Hammond, Katherine B., Junell, Stephanie L., Reed, Jason S., Bimber, Benjamin N., Greene, Justin M., Webb, Gabriela M., Northrup, Mina, Laub, Wolfram, Kievit, Paul, MacAllister, Rhonda, Axthelm, Michael K., Ducore, Rebecca, Lewis, Anne, Colgin, Lois M. A., Hobbs, Theodore, Martin, Lauren D., Ferguson, Betsy, Thomas Jr, Charles R., Panoskaltsis-Mortari, Angela, Meyers, Gabrielle, Stanton, Jeffrey J., Maziarz, Richard T., Sacha, Jonah B.

“…Allogeneic hematopoietic stem cell transplantation (HSCT) is a critically important therapy for hematological malignancies, inborn errors of metabolism, and…”
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The human IL-15 superagonist ALT-803 directs SIV-specific CD8+ T cells into B-cell follicles by Webb, Gabriela M., Li, Shengbin, Mwakalundwa, Gwantwa, Folkvord, Joy M., Greene, Justin M., Reed, Jason S., Stanton, Jeffery J., Legasse, Alfred W., Hobbs, Theodore, Martin, Lauren D., Park, Byung S., Whitney, James B., Jeng, Emily K., Wong, Hing C., Nixon, Douglas F., Jones, R. Brad, Connick, Elizabeth, Skinner, Pamela J., Sacha, Jonah B.

“…Sequestering of latent HIV in follicular helper T cells within B-cell follicles that largely exclude cytotoxic T cells is a major barrier to cellular…”
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Therapeutic neutralizing monoclonal antibody administration protects against lethal yellow fever virus infection by Ricciardi, Michael J, Rust, Lauren N, Pedreño-Lopez, Nuria, Yusova, Sofiya, Biswas, Sreya, Webb, Gabriela M, Gonzalez-Nieto, Lucas, Voigt, Thomas B, Louw, Johan J, Laurino, Fernanda D, DiBello, John R, Raué, Hans-Peter, Barber-Axthelm, Aaron M, Chun, Kimberly, Uttke, Samantha, Raphael, Lidiane M S, Yrizarry-Medina, Aaron, Rosen, Brandon C, Agnor, Rebecca, Gao, Lina, Labriola, Caralyn, Axthelm, Michael, Smedley, Jeremy, Julander, Justin G, Bonaldo, Myrna C, Walker, Laura M, Messaoudi, Ilhem, Slifka, Mark K, Burton, Dennis R, Kallas, Esper G, Sacha, Jonah B, Watkins, David I, Burwitz, Benjamin J

“…Yellow fever virus (YFV) is a reemerging global health threat, driven by several factors, including increased spread of the mosquito vector and rapid…”
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Effect of metabolic status on response to SIV infection and antiretroviral therapy in nonhuman primates by Webb, Gabriela M, Sauter, Kristin A, Takahashi, Diana, Kirigiti, Melissa, Bader, Lindsay, Lindsley, Sarah R, Blomenkamp, Hannah, Zaro, Cicely, Shallman, Molly, McGuire, Casey, Hofmeister, Heather, Avila, Uriel, Pessoa, Cleiton, Hwang, Joseph M, McCullen, Allyson, Humkey, Matthew, Reed, Jason, Gao, Lina, Winchester, Lee, Fletcher, Courtney V, Varlamov, Oleg, Brown, Todd T, Sacha, Jonah B, Kievit, Paul, Roberts, Charles T

“…Current antiretroviral therapy (ART) regimens efficiently limit HIV replication, thereby improving the life expectancy of people living with HIV; however, they…”
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Suppression of human and simian immunodeficiency virus replication with the CCR5-specific antibody Leronlimab in two species by Chang, Xiao L, Reed, Jason S, Webb, Gabriela M, Wu, Helen L, Le, Jimmy, Bateman, Katherine B, Greene, Justin M, Pessoa, Cleiton, Waytashek, Courtney, Weber, Whitney C, Hwang, Joseph, Fischer, Miranda, Moats, Cassandra, Shiel, Oriene, Bochart, Rachele M, Crank, Hugh, Siess, Don, Giobbi, Travis, Torgerson, Jeffrey, Agnor, Rebecca, Gao, Lina, Dhody, Kush, Lalezari, Jacob P, Bandar, Ivo Sah, Carnate, Alnor M, Pang, Alina S, Corley, Michael J, Kelly, Scott, Pourhassan, Nader, Smedley, Jeremy, Bimber, Benjamin N, Hansen, Scott G, Ndhlovu, Lishomwa C, Sacha, Jonah B

“…The CCR5-specific antibody Leronlimab is being investigated as a novel immunotherapy that can suppress HIV replication with minimal side effects. Here we…”
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OP 2.1 CCR5 in HIV Prevention and Cure by Helen L. Wu, Gabriela M. Webb, Jonah B. Sacha

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The Response to Antiretroviral Therapy in Obese SIVInfected Rhesus Macaques by Takahashi, Diana, Sauter, Kristin, Webb, Gabriela, Sacha, Jonah, Kievit, Paul, Roberts, Charles

“…Background: Modern antiretroviral therapy (ART) regimens that include integrase inhibitors are associated with increased risk of metabolic disease. We employed…”
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Optimization and use of near infrared imaging to guide lymph node collection in rhesus macaques (Macaca mulatta) by Smedley, Jeremy V., Bochart, Rachele M., Fischer, Miranda, Funderburgh, Heidi, Kelly, Vanessa, Crank, Hugh, Armantrout, Kim, Shiel, Oriene, Robertson‐LeVay, Mitchell, Sternberger, Nikki, Schmaling, Brian, Roberts, Sheila, Sekiguchi, Vicki, Reusz, Michael, Schwartz, Tiah, Meyer, Kimberly A., Webb, Gabriela, Gilbride, Roxanne M., Dambrauskas, Nicholas, Andrade, Daniela, Wood, Matthew, Labriola, Caralyn, Axthelm, Michael, Derby, Nina, Varco‐Merth, Ben, Fukazawa, Yoshinori, Hansen, Scott, Sacha, Jonah B., Sodora, Donald L., Sather, D. Noah

“…Background Identification of lymph nodes (LNs) draining a specific site or in obese macaques can be challenging. Methods Indocyanine Green (ICG) was…”
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TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection: e1005349 by Chew, Glen M, Fujita, Tsuyoshi, Webb, Gabriela M, Burwitz, Benjamin J, Wu, Helen L, Reed, Jason S, Hammond, Katherine B, Clayton, Kiera L, Ishii, Naoto, Abdel-Mohsen, Mohamed, Liegler, Teri, Mitchell, Brooks I, Hecht, Frederick M, Ostrowski, Mario, Shikuma, Cecilia M, Hansen, Scott G, Maurer, Mark, Korman, Alan J, Deeks, Steven G, Sacha, Jonah B, Ndhlovu, Lishomwa C

“…HIV infection induces phenotypic and functional changes to CD8+ T cells defined by the coordinated upregulation of a series of negative checkpoint receptors…”
Get full text